ABI2

Protein-coding gene in the species Homo sapiens

ABI2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2ED0, 3P8C, 4N78

Identifiers
AliasesABI2, ABI-2, ABI2B, AIP-1, AblBP3, SSH3BP2, argBP1, argBPIA, argBPIB, abl-interactor 2, abl interactor 2, AIP1
External IDsOMIM: 606442; MGI: 106913; HomoloGene: 4209; GeneCards: ABI2; OMA:ABI2 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for ABI2
Genomic location for ABI2
Band2q33.2Start203,328,239 bp[1]
End203,447,728 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for ABI2
Genomic location for ABI2
Band1|1 C2Start60,448,778 bp[2]
End60,520,317 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Brodmann area 23

  • entorhinal cortex

  • middle temporal gyrus

  • postcentral gyrus

  • external globus pallidus

  • internal globus pallidus

  • superior frontal gyrus

  • superior vestibular nucleus

  • ventral tegmental area

  • lateral nuclear group of thalamus
Top expressed in
  • lateral septal nucleus

  • olfactory tubercle

  • anterior amygdaloid area

  • primary motor cortex

  • ventromedial nucleus

  • piriform cortex

  • Region I of hippocampus proper

  • cingulate gyrus

  • subiculum

  • nucleus accumbens
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • SH3 domain binding
  • kinase binding
  • protein binding
  • cytoskeletal anchor activity
  • proline-rich region binding
  • ubiquitin protein ligase binding
  • protein-containing complex binding
  • protein tyrosine kinase activator activity
Cellular component
  • cytoplasm
  • cytosol
  • cell projection
  • SCAR complex
  • cytoskeleton
  • lamellipodium
  • filopodium
  • filopodium tip
  • dendrite
  • nucleus
  • adherens junction
  • cell junction
  • dendritic spine
Biological process
  • positive regulation of Arp2/3 complex-mediated actin nucleation
  • cytoskeleton organization
  • peptidyl-tyrosine phosphorylation
  • Rac protein signal transduction
  • viral process
  • cell migration
  • actin polymerization or depolymerization
  • learning or memory
  • dendrite development
  • camera-type eye development
  • nervous system development
  • regulation of dendritic spine morphogenesis
  • lens fiber cell morphogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10152

329165

Ensembl

ENSG00000138443

ENSMUSG00000026782

UniProt

Q9NYB9

P62484

RefSeq (mRNA)

NM_001282925
NM_001282926
NM_001282927
NM_001282932
NM_005759

NM_001198570
NM_001198571
NM_198127

RefSeq (protein)
NP_001269854
NP_001269855
NP_001269856
NP_001269861
NP_005750

NP_001362591
NP_001362592
NP_001362593
NP_001362594
NP_001362595
NP_001362596
NP_001362597
NP_001362598
NP_001362599
NP_001362600
NP_001362601
NP_001362602
NP_001362603
NP_001362604
NP_001362605
NP_001362606
NP_001362607
NP_001362608
NP_001362609
NP_001362610
NP_001362611
NP_001362612
NP_001362613
NP_001362614
NP_001362615
NP_001362616
NP_001362617
NP_001362618
NP_001362619
NP_001362620
NP_001362621
NP_001362622
NP_001362624
NP_001362625
NP_001362627
NP_001362628
NP_001362631
NP_001362633
NP_001362635
NP_001362636
NP_001362637
NP_001362638
NP_001362639
NP_001362640
NP_001362641
NP_001362643
NP_001362646
NP_001362648
NP_001362650
NP_001362651
NP_001362652
NP_001362653
NP_001362654
NP_001362655
NP_001362656
NP_001362657
NP_001362658
NP_001362659
NP_001362660
NP_001362661
NP_001362662
NP_001362663
NP_001362664
NP_001362665
NP_001362666
NP_001362667
NP_001362668
NP_001362669
NP_001362670
NP_001362671
NP_001362672
NP_001362673
NP_001362674
NP_001362675
NP_001362676
NP_001362677
NP_001362678
NP_001362679
NP_001362680
NP_001362681
NP_001362682
NP_001362683
NP_001362684

NP_001185499
NP_001185500
NP_937760
NP_001391634
NP_001391635

NP_001391636
NP_001391637
NP_001391638
NP_001391639
NP_001391640
NP_001391641
NP_001391642
NP_001391643
NP_001391644
NP_001391645
NP_001391646
NP_001391647
NP_001391648
NP_001391649
NP_001391650

Location (UCSC)Chr 2: 203.33 – 203.45 MbChr 1: 60.45 – 60.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Abl interactor 2 also known as Abelson interactor 2 (Abi-2) is a protein that in humans is encoded by the ABI2 gene.[5][6][7]

Interactions

ABI2 has been shown to interact with ABL1,[5][8] ADAM19,[9] and TRIM32.[10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138443 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026782 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Dai Z, Pendergast AM (December 1995). "Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity". Genes Dev. 9 (21): 2569–82. doi:10.1101/gad.9.21.2569. PMID 7590236.
  6. ^ Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilarino Guell C, Aldred M, Brannon CA, Trembath RC, Nichols WC (September 2000). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium". Genomics. 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520.
  7. ^ "Entrez Gene: ABI2 abl interactor 2".
  8. ^ Cao C, Leng Y, Li C, Kufe D (April 2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response". J. Biol. Chem. 278 (15): 12961–7. doi:10.1074/jbc.M300058200. PMID 12569093.
  9. ^ Huang L, Feng L, Yang L, Zhou W, Zhao S, Li C (September 2002). "Screen and identification of proteins interacting with ADAM19 cytoplasmic tail". Mol. Biol. Rep. 29 (3): 317–23. doi:10.1023/A:1020409217215. PMID 12463424. S2CID 22611084.
  10. ^ Kano S, Miyajima N, Fukuda S, Hatakeyama S (July 2008). "Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2". Cancer Res. 68 (14): 5572–80. doi:10.1158/0008-5472.CAN-07-6231. PMID 18632609.

Further reading

  • Ichigotani Y, Fujii K, Hamaguchi M, Matsuda S (2002). "In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review)". Int. J. Mol. Med. 9 (6): 591–5. doi:10.3892/ijmm.9.6.591. PMID 12011975.
  • Wang B, Mysliwiec T, Krainc D, et al. (1996). "Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene". Oncogene. 12 (9): 1921–9. PMID 8649853.
  • Juang JL, Hoffmann FM (1999). "Drosophila abelson interacting protein (dAbi) is a positive regulator of abelson tyrosine kinase activity". Oncogene. 18 (37): 5138–47. doi:10.1038/sj.onc.1202911. PMID 10498863.
  • Chen B, Borinstein SC, Gillis J, et al. (2000). "The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes". J. Biol. Chem. 275 (25): 19275–81. doi:10.1074/jbc.M908994199. PMID 10858458.
  • Machado RD, Pauciulo MW, Fretwell N, et al. (2001). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium". Genomics. 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520.
  • Courtney KD, Grove M, Vandongen H, et al. (2000). "Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system". Mol. Cell. Neurosci. 16 (3): 244–57. doi:10.1006/mcne.2000.0865. PMID 10995551. S2CID 7370589.
  • Stradal T, Courtney KD, Rottner K, et al. (2001). "The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia". Curr. Biol. 11 (11): 891–5. Bibcode:2001CBio...11..891S. doi:10.1016/S0960-9822(01)00239-1. PMID 11516653. S2CID 1861695.
  • Huang L, Feng L, Yang L, et al. (2003). "Screen and identification of proteins interacting with ADAM19 cytoplasmic tail". Mol. Biol. Rep. 29 (3): 317–23. doi:10.1023/A:1020409217215. PMID 12463424. S2CID 22611084.
  • Mammalian Gene Collection Program Team, Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Cao C, Leng Y, Li C, Kufe D (2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response". J. Biol. Chem. 278 (15): 12961–7. doi:10.1074/jbc.M300058200. PMID 12569093.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Eastman SW, Martin-Serrano J, Chung W, et al. (2005). "Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding". J. Biol. Chem. 280 (1): 628–36. doi:10.1074/jbc.M410384200. PMID 15509564.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Luo X, Levens E, Williams RS, Chegini N (2006). "The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta". Hum. Reprod. 21 (6): 1380–6. doi:10.1093/humrep/del011. PMID 16488906.
  • Hirao N, Sato S, Gotoh T, et al. (2007). "NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation". FEBS Lett. 580 (27): 6464–70. doi:10.1016/j.febslet.2006.10.065. PMID 17101133. S2CID 20005197.
  • Li Y, Clough N, Sun X, et al. (2007). "BCR-ABL Induces Abnormal Cytoskeleton Remodeling, β1 Integrin Clustering, and Increased Cell Adhesion to Fibronectin Through ABL Interactor 1 Pathway". J. Cell Sci. 120 (Pt 8): 1436–46. doi:10.1242/jcs.03430. PMC 1950936. PMID 17389688.



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