ABLIM3

Protein-coding gene in the species Homo sapiens

ABLIM3

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1UJS, 2DJ7

Identifiers

Aliases

ABLIM3, HMFN1661, actin binding LIM protein family member 3

External IDs

OMIM: 611305; MGI: 2442582; HomoloGene: 69175; GeneCards: ABLIM3; OMA:ABLIM3 - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q32	Start	149,141,483 bp^[1]
Band	5q32	End	149,260,542 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)^[2]

Band	18\|18 E1	Start	61,932,463 bp^[2]
Band	18\|18 E1	End	62,044,895 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

apex of heart

right auricle

cardiac muscle tissue of right atrium

glutes

cerebellar hemisphere

right hemisphere of cerebellum

left ventricle

paraflocculus of cerebellum

subcutaneous adipose tissue

right lobe of liver

Top expressed in

lumbar spinal ganglion

right lung lobe

interventricular septum

supraoptic nucleus

trigeminal ganglion

otolith organ

cerebellum

cerebellar cortex

utricle

myocardium of ventricle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	metal ion binding actin binding protein binding
Cellular component	cytoplasm stress fiber lamellipodium
Biological process	cytoskeleton organization actin cytoskeleton organization transcription, DNA-templated lamellipodium assembly positive regulation of transcription by RNA polymerase II positive regulation of protein targeting to mitochondrion cilium assembly
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


22885


319713

Ensembl


ENSG00000173210


ENSMUSG00000032735

UniProt


O94929


Q69ZX8

RefSeq (mRNA)

NM_001301015 NM_001301018 NM_001301027 NM_001301028 NM_014945
NM_001345858 NM_001345859 NM_001345860 NM_001345861 NM_001370417 NM_001370418


NM_001164491 NM_198649 NM_001360868

RefSeq (protein)

NP_001287944 NP_001287947 NP_001287957 NP_001332787 NP_001332788
NP_001332789 NP_001332790 NP_055760 NP_001357346 NP_001357347


NP_001157963 NP_941051 NP_001347797

Location (UCSC)

Chr 5: 149.14 – 149.26 Mb

Chr 18: 61.93 – 62.04 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Actin-binding LIM protein 3 is a protein that in humans is encoded by the ABLIM3 gene.^[5]

Function

The LIM domain is a double zinc finger structure that promotes protein-protein interactions. LIM domain proteins, such as ABLIM3, play roles in embryonic development, cell lineage determination, and cancer.^[6] An important paralog of this gene is LIMS1.

Clinical relevance

Diseases associated with ABLIM3 include hepatoblastoma, and among its related super-pathways are axon guidance and DCC mediated attractive signaling.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173210 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032735 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ABLIM3 actin binding LIM protein family, member 3".
^ Krupp M, Weinmann A, Galle PR, Teufel A (Jan 2006). "Actin binding LIM protein 3 (abLIM3)". International Journal of Molecular Medicine. 17 (1): 129–33. doi:10.3892/ijmm.17.1.129. PMID 16328021.

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Yamada S, Ohira M, Horie H, Ando K, Takayasu H, Suzuki Y, Sugano S, Hirata T, Goto T, Matsunaga T, Hiyama E, Hayashi Y, Ando H, Suita S, Kaneko M, Sasaki F, Hashizume K, Ohnuma N, Nakagawara A (Aug 2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–5911. doi:10.1038/sj.onc.1207782. PMID 15221005. S2CID 3114318.
Zheng B, Wen JK, Han M, Zhou AR (Sep 2004). "hhLIM protein is involved in cardiac hypertrophy". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1690 (1): 1–10. doi:10.1016/j.bbadis.2004.04.009. PMID 15337165.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Krupp M, Weinmann A, Galle PR, Teufel A (Jan 2006). "Actin binding LIM protein 3 (abLIM3)". International Journal of Molecular Medicine. 17 (1): 129–33. doi:10.3892/ijmm.17.1.129. PMID 16328021.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Barrientos T, Frank D, Kuwahara K, Bezprozvannaya S, Pipes GC, Bassel-Duby R, Richardson JA, Katus HA, Olson EN, Frey N (Mar 2007). "Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin". The Journal of Biological Chemistry. 282 (11): 8393–8403. doi:10.1074/jbc.M607549200. PMID 17194709.

External links

Human ABLIM3 genome location and ABLIM3 gene details page in the UCSC Genome Browser.

PDB gallery

1ujs: Solution structure of the Villin headpiece domain of human actin-binding LIM protein homologue (KIAA0843 protein)
2dj7: Solution Structure of 3rd LIM Domain of Actin-binding LIM Protein 3