ACOT12

Protein-coding gene in the species Homo sapiens

ACOT12
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3B7K, 4MOB, 4MOC

Identifiers
AliasesACOT12, CACH-1, Cach, STARD15, THEAL, acyl-CoA thioesterase 12
External IDsOMIM: 614315; MGI: 1921406; HomoloGene: 12540; GeneCards: ACOT12; OMA:ACOT12 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for ACOT12
Genomic location for ACOT12
Band5q14.1Start81,329,996 bp[1]
End81,394,179 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for ACOT12
Genomic location for ACOT12
Band13|13 C3Start91,889,631 bp[2]
End91,934,267 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • testicle

  • buccal mucosa cell

  • human kidney

  • duodenum

  • gonad

  • Achilles tendon

  • stromal cell of endometrium

  • hypothalamus

  • muscle tissue
Top expressed in
  • right kidney

  • human kidney

  • left lobe of liver

  • proximal tubule

  • jejunum

  • intestinal villus

  • duodenum

  • seminiferous tubule

  • epithelium of small intestine

  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • carboxylic ester hydrolase activity
  • ATP binding
  • hydrolase activity
  • lipid binding
  • acetyl-CoA hydrolase activity
  • acyl-CoA hydrolase activity
  • fatty-acyl-CoA binding
  • palmitoyl-CoA hydrolase activity
  • long-chain fatty acyl-CoA binding
  • thiolester hydrolase activity
Cellular component
  • cytoplasm
  • cytosol
Biological process
  • pyruvate metabolic process
  • lipid metabolism
  • acyl-CoA metabolic process
  • acetyl-CoA metabolic process
  • fatty acid metabolic process
  • palmitic acid biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

134526

74156

Ensembl

ENSG00000172497

ENSMUSG00000021620

UniProt

Q8WYK0

Q9DBK0

RefSeq (mRNA)

NM_130767

NM_028790

RefSeq (protein)

NP_570123

NP_083066

Location (UCSC)Chr 5: 81.33 – 81.39 MbChr 13: 91.89 – 91.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Acyl-coenzyme A thioesterase 12 or StAR-related lipid transfer protein 15 (STARD15) is an enzyme that in humans is encoded by the ACOT12 gene.[5][6][7] The protein contains a StAR-related lipid transfer domain.


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172497 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021620 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res. 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.
  6. ^ Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J. 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. S2CID 501610.
  7. ^ "Entrez Gene: ACOT12 acyl-CoA thioesterase 12".
  • Human ACOT12 genome location and ACOT12 gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Acetyl-coenzyme A thioesterase

Further reading

  • Suematsu N, Isohashi F (2007). "Molecular cloning and functional expression of human cytosolic acetyl-CoA hydrolase". Acta Biochim. Pol. 53 (3): 553–61. doi:10.18388/abp.2006_3327. PMID 16951743.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Suematsu N, Okamoto K, Isohashi F (2004). "Simple and unique purification by size-exclusion chromatography for an oligomeric enzyme, rat liver cytosolic acetyl-coenzyme A hydrolase". J. Chromatogr. B. 790 (1–2): 239–44. doi:10.1016/s1570-0232(03)00167-3. PMID 12767336.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suematsu N, Okamoto K, Shibata K, et al. (2001). "Molecular cloning and functional expression of rat liver cytosolic acetyl-CoA hydrolase". Eur. J. Biochem. 268 (9): 2700–9. doi:10.1046/j.1432-1327.2001.02162.x. PMID 11322891.