AGPAT1

Protein-coding gene in the species Homo sapiens

AGPAT1
Identifiers
AliasesAGPAT1, 1-G15, LPAAT-alpha, LPAATA, 1-acylglycerol-3-phosphate O-acyltransferase 1
External IDsOMIM: 603099; MGI: 1932075; HomoloGene: 55973; GeneCards: AGPAT1; OMA:AGPAT1 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for AGPAT1
Genomic location for AGPAT1
Band6p21.32Start32,168,212 bp[1]
End32,178,096 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for AGPAT1
Genomic location for AGPAT1
Band17 B1|17 18.18 cMStart34,823,236 bp[2]
End34,832,423 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right frontal lobe

  • superior frontal gyrus

  • left testis

  • right testis

  • anterior cingulate cortex

  • primary visual cortex

  • stromal cell of endometrium

  • hippocampus proper

  • dorsolateral prefrontal cortex

  • nucleus accumbens
Top expressed in
  • spermatid

  • spermatocyte

  • endocardial cushion

  • muscle of thigh

  • superior frontal gyrus

  • yolk sac

  • primary visual cortex

  • atrioventricular valve

  • dentate gyrus of hippocampal formation granule cell

  • granulocyte
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • acyltransferase activity
  • 1-acylglycerol-3-phosphate O-acyltransferase activity
  • protein binding
Cellular component
  • integral component of membrane
  • endoplasmic reticulum membrane
  • membrane
  • endoplasmic reticulum
Biological process
  • phosphatidic acid biosynthetic process
  • CDP-diacylglycerol biosynthetic process
  • positive regulation of cytokine-mediated signaling pathway
  • positive regulation of cytokine production
  • lipid metabolism
  • phospholipid biosynthetic process
  • phospholipid metabolic process
  • metabolism
  • positive regulation of cellular metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10554

55979

Ensembl
ENSG00000236873
ENSG00000235758
ENSG00000228892
ENSG00000204310
ENSG00000226467

ENSG00000227642
ENSG00000206324

ENSMUSG00000034254

UniProt

Q99943

O35083

RefSeq (mRNA)

NM_006411
NM_032741
NM_001371437
NM_001371438
NM_001371439

NM_001163379
NM_018862

RefSeq (protein)

NP_006402
NP_116130
NP_001358366
NP_001358367
NP_001358368

NP_001156851
NP_061350

Location (UCSC)Chr 6: 32.17 – 32.18 MbChr 17: 34.82 – 34.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

1-acyl-sn-glycerol-3-phosphate acyltransferase alpha is an enzyme that in humans is encoded by the AGPAT1 gene.[5][6][7]

This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein.[7]

References

  1. ^ a b c ENSG00000235758, ENSG00000228892, ENSG00000204310, ENSG00000226467, ENSG00000227642, ENSG00000206324 GRCh38: Ensembl release 89: ENSG00000236873, ENSG00000235758, ENSG00000228892, ENSG00000204310, ENSG00000226467, ENSG00000227642, ENSG00000206324 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034254 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Aguado B, Campbell RD (Mar 1998). "Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex". J Biol Chem. 273 (7): 4096–105. doi:10.1074/jbc.273.7.4096. PMID 9461603.
  6. ^ Stamps AC, Elmore MA, Hill ME, Kelly K, Makda AA, Finnen MJ (Sep 1997). "A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases". Biochem J. 326. ( Pt 2) (2): 455–61. doi:10.1042/bj3260455. PMC 1218691. PMID 9291118.
  7. ^ a b "Entrez Gene: AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)".

Further reading

  • Leung DW (2001). "The structure and functions of human lysophosphatidic acid acyltransferases". Front. Biosci. 6 (1): D944–53. doi:10.2741/Leung. PMID 11487472.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • West J, Tompkins CK, Balantac N, et al. (1997). "Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells". DNA Cell Biol. 16 (6): 691–701. doi:10.1089/dna.1997.16.691. PMID 9212163.
  • Aguado B, Campbell RD (1998). "Human lysophosphatidic acid acyltransferase is encoded by a gene located in the major histocompatibility complex". Biochem. Soc. Trans. 25 (4): S597. doi:10.1042/bst025s597. PMID 9450025.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Servillo L, Balestrieri C, Giovane A, et al. (2006). "Lysophospholipid transacetylase in the regulation of PAF levels in human monocytes and macrophages". FASEB J. 20 (7): 1015–7. doi:10.1096/fj.05-5059fje. PMID 16571775. S2CID 24392328.
  • Lloyd EE, Gaubatz JW, Burns AR, Pownall HJ (2007). "Sustained elevations in NEFA induce cyclooxygenase-2 activity and potentiate THP-1 macrophage foam cell formation". Atherosclerosis. 192 (1): 49–55. doi:10.1016/j.atherosclerosis.2006.06.014. PMID 16870193.


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