CEP57

Protein-coding gene in the species Homo sapiens
CEP57
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4L0R

Identifiers
AliasesCEP57, MVA2, PIG8, TSP57, centrosomal protein 57
External IDsOMIM: 607951; MGI: 1915551; HomoloGene: 8790; GeneCards: CEP57; OMA:CEP57 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for CEP57
Genomic location for CEP57
Band11q21Start95,789,965 bp[1]
End95,832,693 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for CEP57
Genomic location for CEP57
Band9|9 A1Start13,719,088 bp[2]
End13,738,403 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • Achilles tendon

  • sperm

  • ganglionic eminence

  • secondary oocyte

  • gallbladder

  • hair follicle

  • ventricular zone

  • Epithelium of choroid plexus

  • cartilage tissue
Top expressed in
  • seminiferous tubule

  • hand

  • spermatid

  • genital tubercle

  • tail of embryo

  • spermatocyte

  • ventricular zone

  • epiblast

  • abdominal wall

  • thymus
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein homodimerization activity
  • microtubule binding
  • protein binding
  • identical protein binding
  • fibroblast growth factor binding
  • gamma-tubulin binding
Cellular component
  • cytosol
  • centrosome
  • Golgi apparatus
  • microtubule organizing center
  • microtubule
  • cytoskeleton
  • nucleus
  • cytoplasm
  • microtubule cytoskeleton
  • nucleoplasm
Biological process
  • fibroblast growth factor receptor signaling pathway
  • microtubule anchoring
  • G2/M transition of mitotic cell cycle
  • spermatid development
  • mitotic sister chromatid segregation
  • protein homooligomerization
  • ciliary basal body-plasma membrane docking
  • regulation of G2/M transition of mitotic cell cycle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9702

74360

Ensembl

ENSG00000166037

ENSMUSG00000031922

UniProt

Q86XR8

Q8CEE0

RefSeq (mRNA)

NM_001243776
NM_001243777
NM_014679
NM_001363604

NM_026665
NM_001310721

RefSeq (protein)

NP_001230705
NP_001230706
NP_055494
NP_001350533

NP_001297650
NP_080941

Location (UCSC)Chr 11: 95.79 – 95.83 MbChr 9: 13.72 – 13.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centrosomal protein of 57 kDa is a protein that in humans is encoded by the CEP57 gene.[5][6] It is also known as translokin.

Translokin binds basic fibroblast growth factor (FGF2; MIM 134920) and mediates its nuclear translocation and mitogenic activity (Bossard et al., 2003).[supplied by OMIM][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166037 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031922 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
  6. ^ a b "Entrez Gene: CEP57 centrosomal protein 57kDa".
  • Human CEP57 genome location and CEP57 gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Centrosomal protein of 57 kDa

Further reading

  • Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
  • Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Bossard C, Laurell H, Van den Berghe L, et al. (2003). "Translokin is an intracellular mediator of FGF-2 trafficking". Nat. Cell Biol. 5 (5): 433–9. doi:10.1038/ncb979. PMID 12717444. S2CID 21792653.
  • Kim YS, Nakanishi G, Oudes AJ, et al. (2004). "Tsp57: a novel gene induced during a specific stage of spermatogenesis". Biol. Reprod. 70 (1): 106–13. doi:10.1095/biolreprod.103.018465. PMID 12954732.
  • Andersen JS, Wilkinson CJ, Mayor T, et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ahn J, Chung KS, Kim DU, et al. (2005). "Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus". J. Biochem. Mol. Biol. 37 (6): 741–8. doi:10.5483/bmbrep.2004.37.6.741. PMID 15607035.


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