CHST10

Protein-coding gene in the species Homo sapiens
CHST10
Identifiers
AliasesCHST10, HNK-1ST, HNK1ST, carbohydrate sulfotransferase 10
External IDsOMIM: 606376; MGI: 2138283; HomoloGene: 21013; GeneCards: CHST10; OMA:CHST10 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for CHST10
Genomic location for CHST10
Band2q11.2Start100,391,860 bp[1]
End100,417,668 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for CHST10
Genomic location for CHST10
Band1|1 BStart38,902,948 bp[2]
End38,937,242 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • ganglionic eminence

  • lateral nuclear group of thalamus

  • middle temporal gyrus

  • frontal pole

  • Brodmann area 10

  • right frontal lobe

  • Brodmann area 9

  • secondary oocyte

  • putamen
Top expressed in
  • lumbar subsegment of spinal cord

  • visual cortex

  • superior frontal gyrus

  • dentate gyrus of hippocampal formation granule cell

  • primary visual cortex

  • central gray substance of midbrain

  • cerebellar cortex

  • medial dorsal nucleus

  • dorsal tegmental nucleus

  • nucleus of stria terminalis
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • sulfotransferase activity
  • HNK-1 sulfotransferase activity
Cellular component
  • integral component of membrane
  • Golgi membrane
  • Golgi apparatus
  • membrane
Biological process
  • cell adhesion
  • carbohydrate biosynthetic process
  • carbohydrate metabolic process
  • proteoglycan biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9486

98388

Ensembl

ENSG00000115526

ENSMUSG00000026080

UniProt

O43529

Q6PGK7

RefSeq (mRNA)

NM_004854

NM_145142
NM_001368780

RefSeq (protein)

NP_004845

NP_660124
NP_001355709

Location (UCSC)Chr 2: 100.39 – 100.42 MbChr 1: 38.9 – 38.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carbohydrate sulfotransferase 10 is an enzyme that in humans is encoded by the CHST10 gene.[5][6]

Cell surface carbohydrates modulate a variety of cellular functions and are typically synthesized in a stepwise manner. HNK1ST plays a role in the biosynthesis of HNK1 (see MIM 151290), a neuronally expressed carbohydrate that contains a sulfoglucuronyl residue.[supplied by OMIM][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115526 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026080 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kang HG, Evers MR, Xia G, Baenziger JU, Schachner M (Sep 2002). "Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases". J Biol Chem. 277 (38): 34766–72. doi:10.1074/jbc.M204907200. PMID 12080076.
  6. ^ a b "Entrez Gene: CHST10 carbohydrate sulfotransferase 10".

Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ong E, Yeh JC, Ding Y, et al. (1999). "Structure and function of HNK-1 sulfotransferase. Identification of donor and acceptor binding sites by site-directed mutagenesis". J. Biol. Chem. 274 (36): 25608–12. doi:10.1074/jbc.274.36.25608. PMID 10464296.
  • Ong E, Yeh JC, Ding Y, et al. (1998). "Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids". J. Biol. Chem. 273 (9): 5190–5. doi:10.1074/jbc.273.9.5190. PMID 9478973.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Shilatifard A, Merkle RK, Helland DE, et al. (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine". J. Virol. 67 (2): 943–52. doi:10.1128/JVI.67.2.943-952.1993. PMC 237448. PMID 8419650.
  • Bernstein HB, Compans RW (1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein". J. Virol. 66 (12): 6953–9. doi:10.1128/JVI.66.12.6953-6959.1992. PMC 240329. PMID 1433500.


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