CHST11

Protein-coding gene in humans
CHST11
Identifiers
AliasesCHST11, C4ST, C4ST-1, C4ST1, HSA269537, carbohydrate (chondroitin 4) sulfotransferase 11, carbohydrate sulfotransferase 11, OCBMD
External IDsOMIM: 610128; MGI: 1927166; HomoloGene: 56808; GeneCards: CHST11; OMA:CHST11 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for CHST11
Genomic location for CHST11
Band12q23.3Start104,455,295 bp[1]
End104,762,014 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for CHST11
Genomic location for CHST11
Band10|10 C1Start82,821,332 bp[2]
End83,031,734 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibia

  • blood

  • cartilage tissue

  • monocyte

  • bone marrow cells

  • ventricular zone

  • granulocyte

  • amniotic fluid

  • trabecular bone

  • internal globus pallidus
Top expressed in
  • cumulus cell

  • molar

  • fossa

  • medial dorsal nucleus

  • condyle

  • vestibular membrane of cochlear duct

  • substantia nigra

  • subiculum

  • median eminence

  • arcuate nucleus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • sulfotransferase activity
  • N-acetylgalactosamine 4-O-sulfotransferase activity
  • N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity
  • chondroitin 4-sulfotransferase activity
Cellular component
  • Golgi apparatus
  • membrane
  • Golgi membrane
  • integral component of membrane
Biological process
  • embryonic skeletal system morphogenesis
  • chondrocyte development
  • embryonic digit morphogenesis
  • negative regulation of apoptotic process
  • negative regulation of transforming growth factor beta receptor signaling pathway
  • post-embryonic development
  • respiratory gaseous exchange by respiratory system
  • cartilage development
  • developmental growth
  • regulation of cell population proliferation
  • embryonic limb morphogenesis
  • polysaccharide localization
  • post-anal tail morphogenesis
  • embryonic viscerocranium morphogenesis
  • carbohydrate biosynthetic process
  • chondroitin sulfate biosynthetic process
  • chondroitin sulfate metabolic process
  • carbohydrate metabolic process
  • proteoglycan biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

50515

58250

Ensembl

ENSG00000171310

ENSMUSG00000034612

UniProt

Q9NPF2

Q9JME2

RefSeq (mRNA)

NM_018413
NM_001173982

NM_021439

RefSeq (protein)

NP_001167453
NP_060883
NP_060883.1

NP_067414

Location (UCSC)Chr 12: 104.46 – 104.76 MbChr 10: 82.82 – 83.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carbohydrate sulfotransferase 11 is an enzyme that in humans is encoded by the CHST11 gene.[5][6]

Clinical relevance

Mutations in this gene have been associated to susceptibility for osteoarthritis.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171310 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034612 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hiraoka N, Nakagawa H, Ong E, Akama TO, Fukuda MN, Fukuda M (Jun 2000). "Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family". The Journal of Biological Chemistry. 275 (26): 20188–96. doi:10.1074/jbc.M002443200. PMID 10781601.
  6. ^ "Entrez Gene: CHST11 carbohydrate (chondroitin 4) sulfotransferase 11".
  7. ^ Zeggini E, Panoutsopoulou K, Southam L, Rayner NW, Day-Williams AG, Lopes MC, et al. (Sep 2012). "Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study". Lancet. 380 (9844): 815–23. doi:10.1016/S0140-6736(12)60681-3. PMC 3443899. PMID 22763110.

Further reading

  • Yamauchi S, Mita S, Matsubara T, Fukuta M, Habuchi H, Kimata K, Habuchi O (Mar 2000). "Molecular cloning and expression of chondroitin 4-sulfotransferase". The Journal of Biological Chemistry. 275 (12): 8975–81. doi:10.1074/jbc.275.12.8975. PMID 10722746.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Okuda T, Mita S, Yamauchi S, Matsubara T, Yagi F, Yamamori D, Fukuta M, Kuroiwa A, Matsuda Y, Habuchi O (Nov 2000). "Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase". Journal of Biochemistry. 128 (5): 763–70. doi:10.1093/oxfordjournals.jbchem.a022813. PMID 11056388.
  • Mikami T, Mizumoto S, Kago N, Kitagawa H, Sugahara K (Sep 2003). "Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis". The Journal of Biological Chemistry. 278 (38): 36115–27. doi:10.1074/jbc.M306044200. PMID 12847091.
  • Schmidt HH, Dyomin VG, Palanisamy N, Itoyama T, Nanjangud G, Pirc-Danoewinata H, Haas OA, Chaganti RS (Sep 2004). "Deregulation of the carbohydrate (chondroitin 4) sulfotransferase 11 (CHST11) gene in a B-cell chronic lymphocytic leukemia with a t(12;14)(q23;q32)". Oncogene. 23 (41): 6991–6. doi:10.1038/sj.onc.1207934. PMID 15273723.
  • Yamada T, Ohtake S, Sato M, Habuchi O (Dec 2004). "Chondroitin 4-sulphotransferase-1 and chondroitin 6-sulphotransferase-1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues". The Biochemical Journal. 384 (Pt 3): 567–75. doi:10.1042/BJ20040965. PMC 1134142. PMID 15324304.
  • Yusa A, Kitajima K, Habuchi O (May 2005). "N-linked oligosaccharides are required to produce and stabilize the active form of chondroitin 4-sulphotransferase-1". The Biochemical Journal. 388 (Pt 1): 115–21. doi:10.1042/BJ20041573. PMC 1186699. PMID 15628971.


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