CHST4

Protein-coding gene in the species Homo sapiens
CHST4
Identifiers
AliasesCHST4, GST3, GlcNAc6ST2, HECGLCNAC6ST, LSST, carbohydrate sulfotransferase 4
External IDsMGI: 1349479; HomoloGene: 4216; GeneCards: CHST4; OMA:CHST4 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for CHST4
Genomic location for CHST4
Band16q22.2Start71,525,233 bp[1]
End71,538,748 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for CHST4
Genomic location for CHST4
Band8|8 D3Start110,755,785 bp[2]
End110,766,372 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gallbladder

  • pancreatic ductal cell

  • testicle

  • islet of Langerhans

  • mucosa of ileum

  • body of pancreas

  • epithelium of bronchus

  • secondary oocyte

  • nasal epithelium

  • bronchial epithelial cell
Top expressed in
  • colon

  • left colon

  • duodenum

  • morula

  • urethra

  • jejunum

  • ileum

  • epithelium of stomach

  • intestinal villus

  • secondary oocyte
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • sulfotransferase activity
  • N-acetylglucosamine 6-O-sulfotransferase activity
Cellular component
  • integral component of membrane
  • Golgi apparatus
  • intrinsic component of Golgi membrane
  • membrane
  • Golgi membrane
  • trans-Golgi network
Biological process
  • cell-cell signaling
  • cell adhesion
  • immune response
  • O-glycan processing
  • sulfur compound metabolic process
  • protein sulfation
  • inflammatory response
  • N-acetylglucosamine metabolic process
  • keratan sulfate biosynthetic process
  • carbohydrate metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10164

26887

Ensembl

ENSG00000140835

ENSMUSG00000035930

UniProt

Q8NCG5

Q9R1I1

RefSeq (mRNA)

NM_005769
NM_001166395

NM_011998

RefSeq (protein)

NP_001159867
NP_005760

NP_036128

Location (UCSC)Chr 16: 71.53 – 71.54 MbChr 8: 110.76 – 110.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carbohydrate sulfotransferase 4 is an enzyme that in humans is encoded by the CHST4 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000140835 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035930 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bistrup A, Bhakta S, Lee JK, Belov YY, Gunn MD, Zuo FR, Huang CC, Kannagi R, Rosen SD, Hemmerich S (Jul 1999). "Sulfotransferases of Two Specificities Function in the Reconstitution of High Endothelial Cell Ligands for L-selectin". J Cell Biol. 145 (4): 899–910. doi:10.1083/jcb.145.4.899. PMC 2133194. PMID 10330415.
  6. ^ "Entrez Gene: CHST4 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4".

Further reading

  • Bernstein HB, Compans RW (1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein". J. Virol. 66 (12): 6953–9. doi:10.1128/JVI.66.12.6953-6959.1992. PMC 240329. PMID 1433500.
  • Shilatifard A, Merkle RK, Helland DE, et al. (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine". J. Virol. 67 (2): 943–52. doi:10.1128/JVI.67.2.943-952.1993. PMC 237448. PMID 8419650.
  • Hemmerich S, Lee JK, Bhakta S, et al. (2001). "Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family". Glycobiology. 11 (1): 75–87. doi:10.1093/glycob/11.1.75. PMID 11181564.
  • Li X, Tu L, Murphy PG, et al. (2001). "CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin". J. Leukoc. Biol. 69 (4): 565–74. doi:10.1189/jlb.69.4.565. PMID 11310842. S2CID 8888883.
  • Yeh JC, Hiraoka N, Petryniak B, et al. (2001). "Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase". Cell. 105 (7): 957–69. doi:10.1016/S0092-8674(01)00394-4. PMID 11439191. S2CID 18674112.
  • Uchimura K, El-Fasakhany FM, Hori M, et al. (2002). "Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression". J. Biol. Chem. 277 (6): 3979–84. doi:10.1074/jbc.M106587200. PMID 11726653.
  • Seko A, Nagata K, Yonezawa S, Yamashita K (2003). "Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma". Glycobiology. 12 (6): 379–88. doi:10.1093/glycob/12.6.379. PMID 12107080.
  • Akama TO, Misra AK, Hindsgaul O, Fukuda MN (2003). "Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate". J. Biol. Chem. 277 (45): 42505–13. doi:10.1074/jbc.M207412200. PMID 12218059.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • de Graffenried CL, Bertozzi CR (2003). "Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis". J. Biol. Chem. 278 (41): 40282–95. doi:10.1074/jbc.M304928200. PMID 12855678.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • de Graffenried CL, Bertozzi CR (2004). "The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity". J. Biol. Chem. 279 (38): 40035–43. doi:10.1074/jbc.M405709200. PMID 15220337.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Timson G, Banavali S, Gutierrez MI, et al. (2006). "High level expression of N-acetylgluosamine-6-O-sulfotransferase is characteristic of a subgroup of paediatric precursor-B acute lymphoblastic leukaemia". Cancer Lett. 242 (2): 239–44. doi:10.1016/j.canlet.2005.11.012. PMID 16386360.


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