Protein-coding gene in humans
CLEC2B |
---|
|
Identifiers |
---|
Aliases | CLEC2B, AICL, CLECSF2, HP10085, IFNRG1, C-type lectin domain family 2 member B |
---|
External IDs | OMIM: 603242; HomoloGene: 68443; GeneCards: CLEC2B; OMA:CLEC2B - orthologs |
---|
Gene location (Human) |
---|
![Chromosome 12 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/e/e7/Ideogram_human_chromosome_12.svg/300px-Ideogram_human_chromosome_12.svg.png) | Chr. | Chromosome 12 (human)[1] |
---|
| Band | 12p13.31 | Start | 9,852,369 bp[1] |
---|
End | 9,869,386 bp[1] |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - skin of thigh
- skin of hip
- periodontal fiber
- glutes
- vena cava
- pericardium
- mononuclear cell
- human penis
- monocyte
- vulva
|
| | More reference expression data |
|
---|
BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/3/31/PBB_GE_CLEC2B_209732_at_fs.png/250px-PBB_GE_CLEC2B_209732_at_fs.png) | More reference expression data |
|
---|
|
Gene ontology |
---|
Molecular function | - carbohydrate binding
- identical protein binding
| Cellular component | - plasma membrane
- integral component of plasma membrane
- integral component of membrane
- membrane
| Biological process | - regulation of immune response
| Sources:Amigo / QuickGO |
|
Orthologs |
---|
Species | Human | Mouse |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | | |
---|
RefSeq (protein) | | |
---|
Location (UCSC) | Chr 12: 9.85 – 9.87 Mb | n/a |
---|
PubMed search | [2] | n/a |
---|
|
Wikidata |
|
C-type lectin domain family 2 member B is a protein that in humans is encoded by the CLEC2B gene.[3][4]
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) protein superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length nucleotide sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.[4]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000110852 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Hamann J, Montgomery KT, Lau S, Kucherlapati R, van Lier RA (Mar 1997). "AICL: a new activation-induced antigen encoded by the human NK gene complex". Immunogenetics. 45 (5): 295–300. doi:10.1007/s002510050208. PMID 9038101. S2CID 34214844.
- ^ a b "Entrez Gene: CLEC2B C-type lectin domain family 2, member B".
External links
Further reading
- Drickamer K (1999). "C-type lectin-like domains". Curr. Opin. Struct. Biol. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3. PMID 10508765.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily". Proteins. 53 (1): 44–55. doi:10.1002/prot.10440. PMID 12945048. S2CID 30955198.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Renedo M, Arce I, Montgomery K, et al. (2000). "A sequence-ready physical map of the region containing the human natural killer gene complex on chromosome 12p12.3-p13.2". Genomics. 65 (2): 129–36. doi:10.1006/geno.2000.6163. PMID 10783260.
- Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S (1999). "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank". Gene. 228 (1–2): 161–7. doi:10.1016/S0378-1119(99)00004-9. PMID 10072769.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.