CLEC2D

Protein-coding gene in humans

CLEC2D
Available structures
PDBHuman UniProt search: PDBe RCSB
List of PDB id codes

4QKG, 4QKH, 4QKI, 4QKJ, 4WCO

Identifiers
AliasesCLEC2D, CLAX, LLT1, OCIL, C-type lectin domain family 2 member D
External IDsOMIM: 605659; HomoloGene: 137257; GeneCards: CLEC2D; OMA:CLEC2D - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for CLEC2D
Genomic location for CLEC2D
Band12p13.31Start9,664,969 bp[1]
End9,699,553 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • Achilles tendon

  • spleen

  • lymph node

  • blood

  • appendix

  • right uterine tube

  • epithelium of colon

  • monocyte

  • bone marrow cells
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transmembrane signaling receptor activity
  • carbohydrate binding
  • protein binding
Cellular component
  • plasma membrane
  • membrane
  • integral component of membrane
  • endoplasmic reticulum
  • integral component of plasma membrane
  • cell surface
Biological process
  • regulation of immune response
  • cell surface receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

29121

n/a

Ensembl

ENSG00000069493

n/a

UniProt

Q9UHP7

n/a

RefSeq (mRNA)
NM_001004419
NM_001004420
NM_001197317
NM_001197318
NM_001197319

NM_013269

n/a

RefSeq (protein)

NP_001004419
NP_001184246
NP_001184247
NP_001184248
NP_037401

n/a

Location (UCSC)Chr 12: 9.66 – 9.7 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

C-type lectin domain family 2 member D is a protein that in humans is encoded by the CLEC2D gene.[3]

This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified, but the full-length nature of every transcript has not been defined.[3] CLEC2D encodes the gene for the Lectin Like Transcript-1 (LLT1) protein which is a functional ligand for the human NKR-P1A receptor, encoded by the KLRB1 gene. In mice, there are many orthologs of the CLEC2D gene, and the presumed homolog is Clr-b/Ocil (Clec2d). Clr-b has been implicated in missing-self recognition by natural killer cells through engagement of the NKR-P1B receptor.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000069493 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: CLEC2D C-type lectin domain family 2, member D".

Further reading

  • Boles KS, Barten R, Kumaresan PR, et al. (1999). "Cloning of a new lectin-like receptor expressed on human NK cells". Immunogenetics. 50 (1–2): 1–7. doi:10.1007/s002510050679. PMID 10541800. S2CID 30994521.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Iizuka K, Naidenko OV, Plougastel BF, et al. (2003). "Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors". Nat. Immunol. 4 (8): 801–7. doi:10.1038/ni954. PMID 12858173. S2CID 23775959.
  • Hu YS, Zhou H, Myers D, et al. (2004). "Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts". J. Bone Miner. Res. 19 (1): 89–99. doi:10.1359/JBMR.0301215. PMID 14753741. S2CID 28328386.
  • Carlyle JR, Jamieson AM, Gasser S, et al. (2004). "Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3527–32. Bibcode:2004PNAS..101.3527C. doi:10.1073/pnas.0308304101. PMC 373496. PMID 14990792.
  • Mathew PA, Chuang SS, Vaidya SV, et al. (2004). "The LLT1 receptor induces IFN-gamma production by human natural killer cells". Mol. Immunol. 40 (16): 1157–63. doi:10.1016/j.molimm.2003.11.024. PMID 15104121.
  • Gange CT, Quinn JM, Zhou H, et al. (2004). "Characterization of sugar binding by osteoclast inhibitory lectin". J. Biol. Chem. 279 (28): 29043–9. doi:10.1074/jbc.M312518200. PMID 15123656.
  • Aldemir H, Prod'homme V, Dumaurier MJ, et al. (2006). "Cutting edge: lectin-like transcript 1 is a ligand for the CD161 receptor". J. Immunol. 175 (12): 7791–5. doi:10.4049/jimmunol.175.12.7791. PMID 16339512.
  • Rosen DB, Bettadapura J, Alsharifi M, et al. (2006). "Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor". J. Immunol. 175 (12): 7796–9. doi:10.4049/jimmunol.175.12.7796. PMID 16339513.
  • Rosen DB, Cao W, et al. (2008). "Functional Consequences of Interactions between Human NKR-P1A and Its Ligand LLT1 Expressed on Activated Dendritic Cells and B Cells". J. Immunol. 180 (10): 6508–6517. doi:10.4049/jimmunol.180.10.6508. PMC 2577150. PMID 18453569.
  • Human CLEC2D genome location and CLEC2D gene details page in the UCSC Genome Browser.
  • Overview of all the structural information available in the PDB for UniProt: Q9UHP7 (Human C-type lectin domain family 2 member D) at the PDBe-KB.
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