CNKSR3

Protein-coding gene in the species Homo sapiens

CNKSR3
Identifiers
AliasesCNKSR3, MAGI1, CNKSR family member 3, CNK3, CNK3/IPCEF1
External IDsOMIM: 617476; MGI: 2674130; HomoloGene: 18192; GeneCards: CNKSR3; OMA:CNKSR3 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for CNKSR3
Genomic location for CNKSR3
Band6q25.2Start154,387,504 bp[1]
End154,510,659 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for CNKSR3
Genomic location for CNKSR3
Band10|10 A1Start7,069,063 bp[2]
End7,162,237 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • retinal pigment epithelium

  • mucosa of ileum

  • cartilage tissue

  • palpebral conjunctiva

  • amniotic fluid

  • vena cava

  • tibia

  • oral cavity

  • ventricular zone

  • parotid gland
Top expressed in
  • renal corpuscle

  • ciliary body

  • conjunctival fornix

  • lobe of cerebellum

  • endothelial cell of lymphatic vessel

  • cerebellar vermis

  • otolith organ

  • utricle

  • cornea

  • iris
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • membrane
  • plasma membrane
  • apical plasma membrane
Biological process
  • regulation of signal transduction
  • positive regulation of sodium ion transport
  • negative regulation of peptidyl-serine phosphorylation
  • negative regulation of ERK1 and ERK2 cascade
  • positive regulation of sodium ion transmembrane transporter activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

154043

215748

Ensembl

ENSG00000153721

ENSMUSG00000015202

UniProt

Q6P9H4

Q8BMA3

RefSeq (mRNA)

NM_173515

NM_172546

RefSeq (protein)

NP_775786
NP_001355045
NP_001355046
NP_001355047
NP_001355048

NP_766134

Location (UCSC)Chr 6: 154.39 – 154.51 MbChr 10: 7.07 – 7.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CNKSR family member 3 is a protein that in humans is encoded by the CNKSR3 gene. [5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153721 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015202 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CNKSR family member 3". Retrieved 2018-08-31.

Further reading

  • Ziera T, Irlbacher H, Fromm A, Latouche C, Krug SM, Fromm M, Jaisser F, Borden SA (November 2009). "Cnksr3 is a direct mineralocorticoid receptor target gene and plays a key role in the regulation of the epithelial sodium channel". FASEB J. 23 (11): 3936–46. doi:10.1096/fj.09-134759. PMID 19567370. S2CID 7476404.
  • Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
  • Attar MA, Salem JC, Pursel HS, Santy LC (February 2012). "CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration". Exp. Cell Res. 318 (3): 228–37. doi:10.1016/j.yexcr.2011.10.018. PMID 22085542.
  • Shin S, Park JS, Kim YJ, Oh T, An S, Park CS (May 2012). "Differential gene expression profile in PBMCs from subjects with AERD and ATA: a gene marker for AERD". Mol. Genet. Genomics. 287 (5): 361–71. doi:10.1007/s00438-012-0685-9. PMID 22457146. S2CID 14306121.
  • Soundararajan R, Ziera T, Koo E, Ling K, Wang J, Borden SA, Pearce D (September 2012). "Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex". J. Biol. Chem. 287 (39): 33014–25. doi:10.1074/jbc.M112.389148. PMC 3463358. PMID 22851176.
  • Lake SL, Damato BE, Kalirai H, Dodson AR, Taktak AF, Lloyd BH, Coupland SE (March 2013). "Single nucleotide polymorphism array analysis of uveal melanomas reveals that amplification of CNKSR3 is correlated with improved patient survival". Am. J. Pathol. 182 (3): 678–87. doi:10.1016/j.ajpath.2012.11.036. PMID 23357503.


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