COPZ1

Protein-coding gene in humans
COPZ1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2HF6, 5A1U, 5A1V, 5A1W, 5A1X, 5A1Y

Identifiers
AliasesCOPZ1, COPZ, HSPC181, zeta-COP, zeta1-COP, CGI-120, coatomer protein complex subunit zeta 1, COPI coat complex subunit zeta 1
External IDsOMIM: 615472; MGI: 1929063; HomoloGene: 9366; GeneCards: COPZ1; OMA:COPZ1 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for COPZ1
Genomic location for COPZ1
Band12q13.13Start54,301,202 bp[1]
End54,351,846 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for COPZ1
Genomic location for COPZ1
Band15 F3|15 58.74 cMStart103,181,141 bp[2]
End103,208,295 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • islet of Langerhans

  • body of pancreas

  • ventricular zone

  • stromal cell of endometrium

  • ganglionic eminence

  • rectum

  • monocyte

  • right adrenal gland

  • gallbladder

  • smooth muscle tissue
Top expressed in
  • yolk sac

  • dermis

  • duodenum

  • right kidney

  • epithelium of stomach

  • human fetus

  • jejunum

  • islet of Langerhans

  • neural tube

  • choroid plexus of fourth ventricle
More reference expression data
BioGPS
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

22818

56447

Ensembl

ENSG00000111481

ENSMUSG00000060992

UniProt

P61923

P61924

RefSeq (mRNA)

NM_001271734
NM_001271735
NM_001271736
NM_016057

NM_019817
NM_001357748

RefSeq (protein)

NP_001258663
NP_001258664
NP_001258665
NP_057141

NP_062791
NP_001344677

Location (UCSC)Chr 12: 54.3 – 54.35 MbChr 15: 103.18 – 103.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Coatomer subunit zeta-1 is a protein that in humans is encoded by the COPZ1 gene.[5]

Interactions

COPZ1 has been shown to interact with COPG.[6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111481 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060992 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: COPZ1 coatomer protein complex, subunit zeta 1".
  6. ^ Futatsumori M, Kasai K, Takatsu H, Shin HW, Nakayama K (November 2000). "Identification and characterization of novel isoforms of COP I subunits". J. Biochem. 128 (5): 793–801. doi:10.1093/oxfordjournals.jbchem.a022817. PMID 11056392.
  7. ^ Faulstich D, Auerbach S, Orci L, Ravazzola M, Wegchingel S, Lottspeich F, Stenbeck G, Harter C, Wieland FT, Tschochner H (Oct 1996). "Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex" (PDF). J. Cell Biol. 135 (1): 53–61. doi:10.1083/jcb.135.1.53. PMC 2121028. PMID 8858162.

External links

  • Human COPZ1 genome location and COPZ1 gene details page in the UCSC Genome Browser.
  • Overview of all the structural information available in the PDB for UniProt: P61923 (Human Coatomer subunit zeta-1) at the PDBe-KB.

Further reading

  • Pelham HR, Rothman JE (2000). "The debate about transport in the Golgi--two sides of the same coin?". Cell. 102 (6): 713–9. doi:10.1016/S0092-8674(00)00060-X. PMID 11030615. S2CID 18044044.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Pavel J, Harter C, Wieland FT (1998). "Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2140–5. Bibcode:1998PNAS...95.2140P. doi:10.1073/pnas.95.5.2140. PMC 19276. PMID 9482852.
  • Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  • Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Futatsumori M, Kasai K, Takatsu H, Shin HW, Nakayama K (2001). "Identification and characterization of novel isoforms of COP I subunits". J. Biochem. 128 (5): 793–801. doi:10.1093/oxfordjournals.jbchem.a022817. PMID 11056392.
  • v
  • t
  • e
Synaptic vesicle
SNARE
Q-SNARE
R-SNARE
Synaptotagmin
Other
COPICOPIIRME/Clathrin
CaveolaeOther/ungrouped
Vesicle formation
Adaptor protein complex 1:
Adaptor protein complex 2:
Adaptor protein complex 3:
Adaptor protein complex 4:
BLOC-1:
BLOC-2:
BLOC-3:
Coats:
Small GTPase
Other
See also vesicular transport protein disorders


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