Protein-coding gene in humans
CORO1C |
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Identifiers |
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Aliases | CORO1C, HCRNN4, coronin 1C |
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External IDs | OMIM: 605269; MGI: 1345964; HomoloGene: 56537; GeneCards: CORO1C; OMA:CORO1C - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 12 (human)[1] |
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| Band | 12q24.11 | Start | 108,645,109 bp[1] |
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End | 108,731,526 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 5 (mouse)[2] |
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| Band | 5|5 F | Start | 113,980,497 bp[2] |
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End | 114,046,819 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - saphenous vein
- tendon of biceps brachii
- ganglionic eminence
- synovial joint
- Achilles tendon
- stromal cell of endometrium
- epithelium of colon
- urethra
- popliteal artery
- tibial arteries
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| Top expressed in | - stroma of bone marrow
- corneal stroma
- ventricular zone
- yolk sac
- somite
- ileum
- epiblast
- intestinal villus
- ganglionic eminence
- crypt of lieberkuhn of small intestine
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - actin filament binding
- protein binding
- actin binding
| Cellular component | - cytoplasm
- vesicle
- cell projection
- lateral plasma membrane
- membrane
- focal adhesion
- plasma membrane
- flotillin complex
- actin cytoskeleton
- cytoskeleton
- lamellipodium
| Biological process | - regulation of protein phosphorylation
- negative regulation of protein phosphorylation
- positive regulation of lamellipodium morphogenesis
- activation of GTPase activity
- establishment of protein localization
- regulation of epithelial cell migration
- neural crest cell migration
- negative regulation of protein kinase activity by regulation of protein phosphorylation
- phagocytosis
- regulation of focal adhesion assembly
- regulation of ruffle assembly
- negative regulation of substrate adhesion-dependent cell spreading
- regulation of fibroblast migration
- regulation of substrate adhesion-dependent cell spreading
- negative regulation of focal adhesion assembly
- negative regulation of epithelial cell migration
- actin cytoskeleton organization
- signal transduction
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001105237 NM_001276471 NM_014325 |
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RefSeq (protein) | |
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NP_001098707 NP_001263400 NP_055140 |
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Location (UCSC) | Chr 12: 108.65 – 108.73 Mb | Chr 5: 113.98 – 114.05 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Coronin-1C is a protein that in humans is encoded by the CORO1C gene.[5][6][7]
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000110880 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004530 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Okumura M, Kung C, Wong S, Rodgers M, Thomas ML (Oct 1998). "Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein". DNA Cell Biol. 17 (9): 779–87. doi:10.1089/dna.1998.17.779. PMID 9778037.
- ^ de Hostos EL (Oct 1999). "The coronin family of actin-associated proteins". Trends Cell Biol. 9 (9): 345–50. doi:10.1016/S0962-8924(99)01620-7. PMID 10461187.
- ^ a b "Entrez Gene: CORO1C coronin, actin binding protein, 1C".
External links
Further reading
- Rosentreter A, Hofmann A, Xavier CP, et al. (2007). "Coronin 3 involvement in F-actin-dependent processes at the cell cortex". Exp. Cell Res. 313 (5): 878–95. doi:10.1016/j.yexcr.2006.12.015. hdl:10072/14982. PMID 17274980.
- Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Spoerl Z, Stumpf M, Noegel AA, Hasse A (2003). "Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus". J. Biol. Chem. 277 (50): 48858–67. doi:10.1074/jbc.M205136200. PMID 12377779.
- Iizaka M, Han HJ, Akashi H, et al. (2000). "Isolation and chromosomal assignment of a novel human gene, CORO1C, homologous to coronin-like actin-binding proteins". Cytogenet. Cell Genet. 88 (3–4): 221–4. doi:10.1159/000015555. PMID 10828594. S2CID 46548464.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Wick M, Bürger C, Brüsselbach S, et al. (1994). "Identification of serum-inducible genes: different patterns of gene regulation during G0-->S and G1-->S progression". J. Cell Sci. 107 (1): 227–39. doi:10.1242/jcs.107.1.227. PMID 8175911.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.