Protein-coding gene in the species Homo sapiens
CORO2A |
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Identifiers |
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Aliases | CORO2A, CLIPINB, IR10, WDR2, coronin 2A |
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External IDs | OMIM: 602159; MGI: 1345966; HomoloGene: 2546; GeneCards: CORO2A; OMA:CORO2A - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 9 (human)[1] |
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| Band | 9q22.33 | Start | 98,120,975 bp[1] |
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End | 98,192,637 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 4 (mouse)[2] |
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| Band | 4|4 B1 | Start | 46,536,937 bp[2] |
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End | 46,602,202 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - jejunal mucosa
- duodenum
- mucosa of transverse colon
- gallbladder
- human penis
- bronchial epithelial cell
- rectum
- spinal ganglia
- mucosa of pharynx
- mucosa of sigmoid colon
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| Top expressed in | - seminal vesicula
- epithelium of small intestine
- intestinal villus
- ileum
- colon
- lumbar spinal ganglion
- mucous cell of stomach
- left colon
- jejunum
- spermatid
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - actin binding
- actin filament binding
- protein binding
| Cellular component | - actin cytoskeleton
- transcription repressor complex
- intracellular anatomical structure
| Biological process | - actin cytoskeleton organization
- intracellular signal transduction
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 9: 98.12 – 98.19 Mb | Chr 4: 46.54 – 46.6 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Coronin, actin binding protein, 2A is a protein that in humans is encoded by the CORO2A gene.[5]
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008].[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000106789 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028337 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: Coronin, actin binding protein, 2A". Retrieved 2012-01-03.
External links
Further reading
- Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J (March 2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". The EMBO Journal. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. PMC 151047. PMID 12628926.
- Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J (September 2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Molecular Cell. 12 (3): 723–34. doi:10.1016/j.molcel.2003.08.008. PMID 14527417.
- Marshall TW, Aloor HL, Bear JE (September 2009). "Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway". Journal of Cell Science. 122 (Pt 17): 3061–9. doi:10.1242/jcs.051482. PMC 2729258. PMID 19654210.
- Jin Y, Birlea SA, Fain PR, Mailloux CM, Riccardi SL, Gowan K, Holland PJ, Bennett DC, Wallace MR, McCormack WT, Kemp EH, Gawkrodger DJ, Weetman AP, Picardo M, Leone G, Taïeb A, Jouary T, Ezzedine K, van Geel N, Lambert J, Overbeck A, Spritz RA (July 2010). "Common variants in FOXP1 are associated with generalized vitiligo". Nature Genetics. 42 (7): 576–8. doi:10.1038/ng.602. PMC 2893242. PMID 20526340.
- Zaphiropoulos PG, Toftgård R (December 1996). "cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region". DNA and Cell Biology. 15 (12): 1049–56. doi:10.1089/dna.1996.15.1049. PMID 8985118.