CTNNBL1

Protein-coding gene in the species Homo sapiens
CTNNBL1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4CB8, 4CB9, 4CBA, 4HM9, 4HNM, 4MFU, 4MFV

Identifiers
AliasesCTNNBL1, C20orf33, NAP, P14L, PP8304, dJ633O20.1, catenin beta like 1, IMD99
External IDsOMIM: 611537; MGI: 1913892; HomoloGene: 12003; GeneCards: CTNNBL1; OMA:CTNNBL1 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for CTNNBL1
Genomic location for CTNNBL1
Band20q11.23Start37,693,955 bp[1]
End37,872,129 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for CTNNBL1
Genomic location for CTNNBL1
Band2 H1|2 78.4 cMStart157,579,321 bp[2]
End157,733,534 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • spleen

  • monocyte

  • ganglionic eminence

  • apex of heart

  • granulocyte

  • ventricular zone

  • right auricle

  • muscle layer of sigmoid colon
Top expressed in
  • otic vesicle

  • spermatid

  • primary oocyte

  • saccule

  • spermatocyte

  • otic placode

  • primitive streak

  • seminiferous tubule

  • renal corpuscle

  • medullary collecting duct
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • enzyme binding
  • protein binding
Cellular component
  • cytoplasm
  • spliceosomal complex
  • membrane
  • nucleus
  • Prp19 complex
  • nucleoplasm
Biological process
  • positive regulation of apoptotic process
  • mRNA splicing, via spliceosome
  • mRNA processing
  • somatic diversification of immunoglobulins
  • apoptotic process
  • RNA splicing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

56259

66642

Ensembl

ENSG00000132792

ENSMUSG00000027649

UniProt

Q8WYA6

Q9CWL8

RefSeq (mRNA)

NM_001281495
NM_030877

NM_025680

RefSeq (protein)

NP_001268424
NP_110517

NP_079956

Location (UCSC)Chr 20: 37.69 – 37.87 MbChr 2: 157.58 – 157.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Beta-catenin-like protein 1 is a protein that in humans is encoded by the CTNNBL1 gene.[5][6]

The protein encoded by this gene contains an acidic domain, a putative bipartite nuclear localization signal, a nuclear export signal, a leucine-isoleucine zipper, and phosphorylation motifs. In addition, the encoded protein contains Armadillo/beta-catenin-like repeats, which have been implicated in protein-protein interactions. Although the function of this protein has not been determined, the C-terminal portion of the protein has been shown to possess apoptosis-inducing activity.[6] It is a housekeeping gene.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132792 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027649 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jabbour L, Welter JF, Kollar J, Hering TM (Mar 2003). "Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene--evidence for a role in apoptosis". Genomics. 81 (3): 292–303. doi:10.1016/S0888-7543(02)00038-1. PMID 12659813.
  6. ^ a b "Entrez Gene: CTNNBL1 catenin, beta like 1".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.


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