CYFIP1 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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3P8C, 4N78 |
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Identifiers |
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Aliases | CYFIP1, P140SRA-1, SHYC, SRA-1, SRA1, cytoplasmic FMR1 interacting protein 1 |
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External IDs | OMIM: 606322; MGI: 1338801; HomoloGene: 22628; GeneCards: CYFIP1; OMA:CYFIP1 - orthologs |
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Gene location (Human) |
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![Chromosome 15 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/0/07/Ideogram_human_chromosome_15.svg/300px-Ideogram_human_chromosome_15.svg.png) | Chr. | Chromosome 15 (human)[1] |
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| Band | 15q11.2 | Start | 22,867,052 bp[1] |
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End | 22,981,063 bp[1] |
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Gene location (Mouse) |
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![Chromosome 7 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Ideogram_house_mouse_chromosome_7.svg/260px-Ideogram_house_mouse_chromosome_7.svg.png) | Chr. | Chromosome 7 (mouse)[2] |
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| Band | 7|7 B5 | Start | 55,491,493 bp[2] |
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End | 55,582,350 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - germinal epithelium
- gingival epithelium
- parietal pleura
- visceral pleura
- oral cavity
- tibia
- palpebral conjunctiva
- skin of hip
- mucosa of sigmoid colon
- skin of thigh
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| Top expressed in | - saccule
- otic placode
- sciatic nerve
- otic vesicle
- Ileal epithelium
- dermis
- stroma of bone marrow
- endothelial cell of lymphatic vessel
- skin of external ear
- gastrula
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/a/a9/PBB_GE_CYFIP1_208923_at_fs.png/250px-PBB_GE_CYFIP1_208923_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - actin binding
- protein-containing complex binding
- actin filament binding
- protein binding
- RNA 7-methylguanosine cap binding
- translation regulator activity
| Cellular component | - extracellular exosome
- cytoplasm
- synapse
- cell projection
- cell junction
- cytosol
- SCAR complex
- focal adhesion
- lamellipodium
- perinuclear region of cytoplasm
- ruffle
- mRNA cap binding complex
- neuron projection
- extracellular region
- filopodium tip
- secretory granule lumen
- specific granule lumen
- neuronal cell body
- terminal bouton
- dendritic spine
- dendritic growth cone
- axonal growth cone
- excitatory synapse
- central region of growth cone
- peripheral region of growth cone
- tertiary granule lumen
- postsynapse
| Biological process | - Rac protein signal transduction
- cognition
- Fc-gamma receptor signaling pathway involved in phagocytosis
- multicellular organism development
- ruffle organization
- axon extension
- vascular endothelial growth factor receptor signaling pathway
- nervous system development
- regulation of cell shape
- cell differentiation
- positive regulation of Arp2/3 complex-mediated actin nucleation
- lamellipodium assembly
- cellular response to insulin stimulus
- neutrophil degranulation
- positive regulation of axon extension
- positive regulation of axonogenesis
- response to electrical stimulus
- positive regulation of dendrite development
- positive regulation of ruffle assembly
- negative regulation of synaptic vesicle recycling
- neuron projection development
- positive regulation of neurotrophin TRK receptor signaling pathway
- dendrite extension
- regulation of translation
- modification of synaptic structure
- cell morphogenesis
- axon guidance
- cell projection assembly
- regulation of translation at postsynapse, modulating synaptic transmission
- regulation of modification of postsynaptic actin cytoskeleton
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | |
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ENSG00000280618 ENSG00000273749 ENSG00000288461 |
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UniProt | | |
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RefSeq (mRNA) | NM_001033028 NM_001287810 NM_014608 NM_001324119 NM_001324120
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NM_001324122 NM_001324123 NM_001324124 NM_001324125 NM_001324126 |
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NM_001164661 NM_001164662 NM_011370 |
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RefSeq (protein) | NP_001028200 NP_001274739 NP_001311048 NP_001311049 NP_001311051
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NP_001311052 NP_001311053 NP_001311054 NP_001311055 NP_055423 |
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NP_001158133 NP_001158134 NP_035500 |
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Location (UCSC) | Chr 15: 22.87 – 22.98 Mb | Chr 7: 55.49 – 55.58 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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