Colforsin daropate
Chemical compound
- none
- In general: ℞ (Prescription only)
- [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-acetyloxy-3-ethenyl-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-6-yl] 3-dimethylaminopropanoate
- 113462-26-3 Y
- HCl: 138605-00-2 Y
- 444029
- HCl: 444028
- 392052 N
- HCl: 392051
- 1196KQZ976
- HCl: C6P4R272GT
- HCl: D01697
- DTXSID20150415
- HCl: DTXSID90930165
- Interactive image
- CC(=O)O[C@H]1[C@H]([C@H]2C(CC[C@@H]([C@@]2([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O)(C)C)OC(=O)CCN(C)C
InChI
- InChI=1S/C27H43NO8/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24/h10,17,20-22,30,33H,1,11-15H2,2-9H3/t17-,20-,21-,22-,24-,25-,26+,27-/m0/s1 N
- Key:RSOZZQTUMVBTMR-XGUNBQNXSA-N N
Colforsin daropate is a carboxylic ester derived from the condensation of forskolin (colforsin) with N,N-dimethyl-β-alanine.[1]
Its water-soluble hydrochloride salt (NKH 477)[2] is an adenylyl cyclase activator which has been studied for its cardiac selectivity.[3][4]
References
- ^ "colforsin daropate". ChEBI. EMBL-EBI. Retrieved 6 January 2022.
- ^ "β-Alanine, N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester, hydrochloride (1:1)". CAS Common Chemistry. American Chemical Society. Retrieved 6 January 2022.
- ^ Mori M, Takeuchi M, Takaoka H, Hata K, Hayashi Y, Yokoyama M (August 1994). "Effect of NKH477, a new water-soluble forskolin derivative, on arterial-ventricular coupling and mechanical energy transduction in patients with left ventricular systolic dysfunction: comparison with dobutamine". J. Cardiovasc. Pharmacol. 24 (2): 310–6. doi:10.1097/00005344-199424020-00018. PMID 7526066.
- ^ Sanbe A, Takeo S (July 1995). "Effects of NKH477, a water-soluble forskolin derivative, on cardiac function in rats with chronic heart failure after myocardial infarction". J. Pharmacol. Exp. Ther. 274 (1): 120–6. PMID 7616388.
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- Receptor/signaling modulators
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