CorA metal ion transporter

CorA-like Mg2+ transporter protein
Structure of the CorA Mg2+ transporter.[1]
Identifiers
Symbol	CorA
Pfam	PF01544
InterPro	IPR002523
TCDB	1.A.35
OPM superfamily	66
OPM protein	2bbj
CDD	cd11744
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary PDB 2bbhA:56-266 2bbjD:56-351

The CorA transport system is the primary Mg²⁺ influx system of Salmonella typhimurium and Escherichia coli.^[2][3] CorA is ubiquitous in the Bacteria and Archaea. There are also eukaryotic members of the family localized to the mitochondrial membrane such as MRS2 and Lpe10 in yeast.

Subfamilies

• Magnesium and cobalt transport protein CorA InterPro: IPR004488

Human proteins containing this domain

MRS2L;

References

Further reading

• Kehres DG, Lawyer CH, Maguire ME (1998). "The CorA magnesium transporter gene family". Microb. Comp. Genom. 3 (3): 151–69. doi:10.1089/omi.1.1998.3.151. PMID 9775386.
• Smith RL, Szegedy MA, Kucharski LM, et al. (October 1998). "The CorA Mg2+ transport protein of Salmonella typhimurium. Mutagenesis of conserved residues in the third membrane domain identifies a Mg2+ pore". J. Biol. Chem. 273 (44): 28663–9. doi:10.1074/jbc.273.44.28663. PMID 9786860.
• Wiesenberger G, Waldherr M, Schweyen RJ (April 1992). "The nuclear gene MRS2 is essential for the excision of group II introns from yeast mitochondrial transcripts in vivo". J. Biol. Chem. 267 (10): 6963–9. doi:10.1016/S0021-9258(19)50522-1. PMID 1551905.