Cysteine dioxygenase type 1

Protein-coding gene in the species Homo sapiens
CDO1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2IC1

Identifiers
AliasesCDO1, CDO-I, cysteine dioxygenase type 1
External IDsOMIM: 603943; MGI: 105925; HomoloGene: 1365; GeneCards: CDO1; OMA:CDO1 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CDO1
Genomic location for CDO1
Band5q22.3Start115,804,733 bp[1]
End115,816,659 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for CDO1
Genomic location for CDO1
Band18 C|18 24.75 cMStart46,846,260 bp[2]
End46,861,462 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • ventricular zone

  • retinal pigment epithelium

  • corpus epididymis

  • right lobe of liver

  • Epithelium of choroid plexus

  • synovial joint

  • seminal vesicula

  • tibial nerve

  • ganglionic eminence
Top expressed in
  • seminal vesicula

  • white adipose tissue

  • gallbladder

  • brown adipose tissue

  • tunica adventitia of aorta

  • zygote

  • corneal stroma

  • lactiferous gland

  • left lobe of liver

  • intercostal muscle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • iron ion binding
  • dioxygenase activity
  • metal ion binding
  • oxidoreductase activity
  • ferrous iron binding
  • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
  • cysteine dioxygenase activity
Cellular component
  • cytosol
Biological process
  • response to amino acid
  • response to glucagon
  • taurine biosynthetic process
  • cysteine metabolic process
  • response to glucocorticoid
  • response to organonitrogen compound
  • response to cAMP
  • lactation
  • response to ethanol
  • sulfur amino acid biosynthetic process
  • inflammatory response
  • L-cysteine catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1036

12583

Ensembl

ENSG00000129596

ENSMUSG00000033022

UniProt

Q16878

P60334

RefSeq (mRNA)

NM_001801
NM_001323565
NM_001323566
NM_001323567

NM_033037

RefSeq (protein)

NP_001310494
NP_001310495
NP_001310496
NP_001792

NP_149026

Location (UCSC)Chr 5: 115.8 – 115.82 MbChr 18: 46.85 – 46.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cysteine dioxygenase type 1 is a protein that in humans is encoded by the CDO1 gene. [5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000129596 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033022 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Cysteine dioxygenase type 1". Retrieved 2016-06-16.

Further reading

  • Dominy JE, Hwang J, Stipanuk MH (2007). "Overexpression of cysteine dioxygenase reduces intracellular cysteine and glutathione pools in HepG2/C3A cells". Am. J. Physiol. Endocrinol. Metab. 293 (1): E62–9. doi:10.1152/ajpendo.00053.2007. PMID 17327371. S2CID 9472341.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Cysteine dioxygenase type 1
  • PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Cysteine dioxygenase type 1


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