DCAF11

Protein-coding gene in the species Danio rerio
DCAF11
Identifiers
AliasesDCAF11, PRO2389, WDR23, GL014, DDB1 and CUL4 associated factor 11
External IDsOMIM: 613317; MGI: 90168; HomoloGene: 11886; GeneCards: DCAF11; OMA:DCAF11 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for DCAF11
Genomic location for DCAF11
Band14q12Start24,114,195 bp[1]
End24,125,242 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for DCAF11
Genomic location for DCAF11
Band14 C3|14 28.19 cMStart55,797,463 bp[2]
End55,807,522 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • duodenum

  • body of pancreas

  • sural nerve

  • skeletal muscle tissue

  • blood

  • granulocyte

  • muscle of leg

  • bone marrow

  • gastrocnemius muscle
Top expressed in
  • left lobe of liver

  • ankle

  • vestibular membrane of cochlear duct

  • right kidney

  • muscle of thigh

  • transitional epithelium of urinary bladder

  • temporal muscle

  • right ventricle

  • sternocleidomastoid muscle

  • triceps brachii muscle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • Cul4-RING E3 ubiquitin ligase complex
  • nucleoplasm
Biological process
  • post-translational protein modification
  • protein ubiquitination
  • proteasome-mediated ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

80344

28199

Ensembl

ENSG00000100897
ENSG00000284796

ENSMUSG00000022214

UniProt

Q8TEB1

Q91VU6

RefSeq (mRNA)

NM_001163484
NM_025230
NM_181357

NM_001199009
NM_133734

RefSeq (protein)

NP_001156956
NP_079506
NP_852002

NP_001185938
NP_598495

Location (UCSC)Chr 14: 24.11 – 24.13 MbChr 14: 55.8 – 55.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DDB1- and CUL4-associated factor 11 also known as WD Repeat Domain 23 (WDR23) is a protein that in humans is encoded by the DCAF11 gene.


DCAF11 is a WD40 repeat protein, containing seven repeats of the closed circular solenoid protein domain WD40.[5] WDR-23 exists in two spatially distinct isoforms produced by alternative splicing, a cytoplasmic WDR-23A and nuclear WDR-23B. Nuclear and cytoplasmic versions of WDR-23 have distinct roles.[6]

References

  1. ^ a b c ENSG00000284796 GRCh38: Ensembl release 89: ENSG00000100897, ENSG00000284796 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022214 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Choe KP, Przybysz AJ, Strange K (May 2009). "The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans". Molecular and Cellular Biology. 29 (10): 2704–2715. doi:10.1128/MCB.01811-08. PMC 2682033. PMID 19273594.
  6. ^ Spatola BN, Lo JY, Wang B, Curran SP (August 2019). "Nuclear and cytoplasmic WDR-23 isoforms mediate differential effects on GEN-1 and SKN-1 substrates". Scientific Reports. 9 (1): 11783. Bibcode:2019NatSR...911783S. doi:10.1038/s41598-019-48286-y. PMC 6692315. PMID 31409866. This article incorporates text from this source, which is available under the CC BY 4.0 license.

Further reading

  • Siswanto FM, Oguro A, Arase S, Imaoka S (October 2020). "WDR23 regulates the expression of Nrf2-driven drug-metabolizing enzymes". Drug Metabolism and Pharmacokinetics. 35 (5): 441–455. doi:10.1016/j.dmpk.2020.06.007. PMID 32839090. S2CID 221307354.
  • Zhang X, Luukkonen LM, Eissler CL, Crowley VM, Yamashita Y, Schafroth MA, et al. (April 2021). "DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras". Journal of the American Chemical Society. 143 (13): 5141–5149. doi:10.1021/jacs.1c00990. PMC 8309050. PMID 33783207.
  • Le R, Huang Y, Zhang Y, Wang H, Lin J, Dong Y, et al. (April 2021). "Dcaf11 activates Zscan4-mediated alternative telomere lengthening in early embryos and embryonic stem cells". Cell Stem Cell. 28 (4): 732–747.e9. doi:10.1016/j.stem.2020.11.018. PMID 33357405. S2CID 229693249.
  • Wang K, Liu Y, Yu Z, Gu B, Hu J, Huang L, et al. (November 2021). "Phosphorylation at Ser68 facilitates DCAF11-mediated ubiquitination and degradation of CENP-A during the cell cycle". Cell Reports. 37 (6): 109987. doi:10.1016/j.celrep.2021.109987. PMID 34758320. S2CID 243952009.
  • Siswanto FM, Sakuma R, Oguro A, Imaoka S (August 2022). "Chlorogenic Acid Activates Nrf2/SKN-1 and Prolongs the Lifespan of Caenorhabditis elegans via the Akt-FOXO3/DAF16a-DDB1 Pathway and Activation of DAF16f". The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 77 (8): 1503–1516. doi:10.1093/gerona/glac062. PMID 35279029.
  • v
  • t
  • e