DDOST

Protein-coding gene in the species Homo sapiens
DDOST
Identifiers
AliasesDDOST, AGER1, CDG1R, OKSWcl45, OST, OST48, WBP1, dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit, GATD6
External IDsOMIM: 602202; MGI: 1194508; HomoloGene: 3821; GeneCards: DDOST; OMA:DDOST - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for DDOST
Genomic location for DDOST
Band1p36.12Start20,651,767 bp[1]
End20,661,544 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for DDOST
Genomic location for DDOST
Band4|4 D3Start138,032,041 bp[2]
End138,039,939 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • corpus epididymis

  • stromal cell of endometrium

  • body of pancreas

  • caput epididymis

  • islet of Langerhans

  • rectum

  • smooth muscle tissue

  • placenta

  • beta cell

  • spleen
Top expressed in
  • parotid gland

  • lacrimal gland

  • seminal vesicula

  • gastrula

  • dermis

  • islet of Langerhans

  • molar

  • stroma of bone marrow

  • vestibular sensory epithelium

  • crypt of lieberkuhn of small intestine
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • dolichyl-diphosphooligosaccharide-protein glycotransferase activity
  • protein binding
  • oligosaccharyl transferase activity
Cellular component
  • integral component of membrane
  • endoplasmic reticulum membrane
  • membrane
  • intracellular membrane-bounded organelle
  • endoplasmic reticulum
  • oligosaccharyltransferase complex
  • plasma membrane
  • azurophil granule membrane
  • protein-containing complex
Biological process
  • response to cytokine
  • protein N-linked glycosylation via asparagine
  • protein glycosylation
  • protein N-linked glycosylation
  • T cell activation
  • neutrophil degranulation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1650

13200

Ensembl

ENSG00000244038

ENSMUSG00000028757

UniProt

P39656

O54734

RefSeq (mRNA)

NM_005216

NM_007838

RefSeq (protein)

NP_005207

NP_031864

Location (UCSC)Chr 1: 20.65 – 20.66 MbChr 4: 138.03 – 138.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase 48 kDa subunit is an enzyme that in humans is encoded by the DDOST gene.[5][6]

This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000244038 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028757 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yamagata T, Tsuru T, Momoi MY, Suwa K, Nozaki Y, Mukasa T, Ohashi H, Fukushima Y, Momoi T (Jan 1998). "Genome organization of human 48-kDa oligosaccharyltransferase (DDOST)". Genomics. 45 (3): 535–40. doi:10.1006/geno.1997.4966. PMID 9367678.
  6. ^ a b "Entrez Gene: DDOST dolichyl-diphosphooligosaccharide-protein glycosyltransferase".

Further reading

  • Kumar V, Korza G, Heinemann FS, Ozols J (1995). "Human oligosaccharyltransferase: isolation, characterization, and the complete amino acid sequence of 50-kDa subunit". Arch. Biochem. Biophys. 320 (2): 217–23. doi:10.1016/0003-9861(95)90003-9. PMID 7625827.
  • Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
  • Stitt AW, He C, Vlassara H (1999). "Characterization of the advanced glycation end-product receptor complex in human vascular endothelial cells". Biochem. Biophys. Res. Commun. 256 (3): 549–56. doi:10.1006/bbrc.1999.0291. PMID 10080935.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lu C, He JC, Cai W, et al. (2004). "Advanced glycation endproduct (AGE) receptor 1 is a negative regulator of the inflammatory response to AGE in mesangial cells". Proc. Natl. Acad. Sci. U.S.A. 101 (32): 11767–72. Bibcode:2004PNAS..10111767L. doi:10.1073/pnas.0401588101. PMC 511050. PMID 15289604.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Shibatani T, David LL, McCormack AL, et al. (2005). "Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits". Biochemistry. 44 (16): 5982–92. doi:10.1021/bi047328f. PMID 15835887.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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