DGKQ

Protein-coding gene in the species Homo sapiens
DGKQ
Identifiers
AliasesDGKQ, DAGK, DAGK4, DAGK7, diacylglycerol kinase theta
External IDsOMIM: 601207; MGI: 102918; HomoloGene: 20352; GeneCards: DGKQ; OMA:DGKQ - orthologs
EC number2.7.1.107
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for DGKQ
Genomic location for DGKQ
Band4p16.3Start958,887 bp[1]
End986,895 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for DGKQ
Genomic location for DGKQ
Band5 F|5 53.24 cMStart108,794,559 bp[2]
End108,817,538 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of ileum

  • pancreatic ductal cell

  • granulocyte

  • jejunal mucosa

  • mucosa of transverse colon

  • right hemisphere of cerebellum

  • middle temporal gyrus

  • duodenum

  • mucosa of sigmoid colon

  • thymus
Top expressed in
  • primary visual cortex

  • superior frontal gyrus

  • cerebellar cortex

  • dentate gyrus of hippocampal formation granule cell

  • right kidney

  • lip

  • genital tubercle

  • neural layer of retina

  • jejunum

  • granulocyte
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • phospholipase binding
  • metal ion binding
  • kinase activity
  • kinase binding
  • protein binding
  • ATP binding
  • diacylglycerol kinase activity
  • transmembrane receptor protein tyrosine kinase activator activity
  • NAD+ kinase activity
Cellular component
  • cytoplasm
  • cytosol
  • nuclear speck
  • membrane
  • plasma membrane
  • cytoskeleton
  • nucleus
  • endosome
  • vesicle membrane
  • nuclear matrix
  • presynapse
  • postsynapse
  • glutamatergic synapse
Biological process
  • G protein-coupled receptor signaling pathway
  • thrombin-activated receptor signaling pathway
  • response to ATP
  • intracellular signal transduction
  • phosphorylation
  • regulation of transcription by RNA polymerase II
  • protein kinase C signaling
  • platelet activation
  • protein kinase C-activating G protein-coupled receptor signaling pathway
  • signal transduction
  • glycerolipid metabolic process
  • diacylglycerol metabolic process
  • lipid phosphorylation
  • regulation of gluconeogenesis
  • phosphatidic acid biosynthetic process
  • activation of transmembrane receptor protein tyrosine kinase activity
  • regulation of G protein-coupled receptor signaling pathway
  • positive regulation of gene expression
  • negative regulation of gene expression
  • negative regulation of peptidyl-threonine phosphorylation
  • peptidyl-serine phosphorylation
  • cAMP-mediated signaling
  • positive regulation of peptidyl-tyrosine phosphorylation
  • response to cAMP
  • regulation of cholesterol metabolic process
  • regulation of TORC1 signaling
  • regulation of cortisol biosynthetic process
  • regulation of progesterone biosynthetic process
  • metabolism
  • regulation of synaptic vesicle endocytosis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1609

110524

Ensembl

ENSG00000145214

ENSMUSG00000004815

UniProt

P52824

Q6P5E8

RefSeq (mRNA)

NM_001347

NM_199011
NM_001357029

RefSeq (protein)

NP_001338

NP_950176
NP_001343958

Location (UCSC)Chr 4: 0.96 – 0.99 MbChr 5: 108.79 – 108.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Diacylglycerol kinase theta is an enzyme that in humans is encoded by the DGKQ gene.[5][6][7]

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.[7]

Interactions

DGKQ has been shown to interact with RHOA.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145214 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004815 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Endele S, Zabel B, Winterpacht A (Jun 1996). "Assignment of the human diacylglycerol kinase 4 (DAGK4) gene to chromosome 4p16.3". Genomics. 33 (1): 145–6. doi:10.1006/geno.1996.0174. PMID 8617502.
  6. ^ Houssa B, Schaap D, van der Wal J, Goto K, Kondo H, Yamakawa A, Shibata M, Takenawa T, van Blitterswijk WJ (May 1997). "Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain". J Biol Chem. 272 (16): 10422–8. doi:10.1074/jbc.272.16.10422. PMID 9099683.
  7. ^ a b "Entrez Gene: DGKQ diacylglycerol kinase, theta 110kDa".
  8. ^ Houssa, B; de Widt J; Kranenburg O; Moolenaar W H; van Blitterswijk W J (Mar 1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA". J. Biol. Chem. 274 (11): 6820–2. doi:10.1074/jbc.274.11.6820. ISSN 0021-9258. PMID 10066731.

Further reading

  • Sakane F, Kanoh H (1998). "Molecules in focus: diacylglycerol kinase". Int. J. Biochem. Cell Biol. 29 (10): 1139–43. doi:10.1016/S1357-2725(97)00037-X. PMID 9438377.
  • Li D, Urs AN, Allegood J, et al. (2008). "Cyclic AMP-Stimulated Interaction between Steroidogenic Factor 1 and Diacylglycerol Kinase θ Facilitates Induction of CYP17". Mol. Cell. Biol. 27 (19): 6669–85. doi:10.1128/MCB.00355-07. PMC 2099220. PMID 17664281.
  • van Baal J, de Widt J, Divecha N, van Blitterswijk WJ (2005). "Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C". J. Biol. Chem. 280 (11): 9870–8. doi:10.1074/jbc.M409301200. PMID 15632189.
  • Tabellini G, Bortul R, Santi S, et al. (2003). "Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus". Exp. Cell Res. 287 (1): 143–54. doi:10.1016/S0014-4827(03)00115-0. PMID 12799190.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Houssa B, de Widt J, Kranenburg O, et al. (1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA". J. Biol. Chem. 274 (11): 6820–2. doi:10.1074/jbc.274.11.6820. PMID 10066731.
  • Sakane F, Imai S, Kai M, et al. (1996). "Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases". J. Biol. Chem. 271 (14): 8394–401. doi:10.1074/jbc.271.14.8394. PMID 8626538.


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