Protein-coding gene in the species Homo sapiens
DGKQ |
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Identifiers |
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Aliases | DGKQ, DAGK, DAGK4, DAGK7, diacylglycerol kinase theta |
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External IDs | OMIM: 601207; MGI: 102918; HomoloGene: 20352; GeneCards: DGKQ; OMA:DGKQ - orthologs |
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EC number | 2.7.1.107 |
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Gene location (Human) |
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| Chr. | Chromosome 4 (human)[1] |
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| Band | 4p16.3 | Start | 958,887 bp[1] |
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End | 986,895 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 5 (mouse)[2] |
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| Band | 5 F|5 53.24 cM | Start | 108,794,559 bp[2] |
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End | 108,817,538 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - mucosa of ileum
- pancreatic ductal cell
- granulocyte
- jejunal mucosa
- mucosa of transverse colon
- right hemisphere of cerebellum
- middle temporal gyrus
- duodenum
- mucosa of sigmoid colon
- thymus
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| Top expressed in | - primary visual cortex
- superior frontal gyrus
- cerebellar cortex
- dentate gyrus of hippocampal formation granule cell
- right kidney
- lip
- genital tubercle
- neural layer of retina
- jejunum
- granulocyte
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - transferase activity
- nucleotide binding
- phospholipase binding
- metal ion binding
- kinase activity
- kinase binding
- protein binding
- ATP binding
- diacylglycerol kinase activity
- transmembrane receptor protein tyrosine kinase activator activity
- NAD+ kinase activity
| Cellular component | - cytoplasm
- cytosol
- nuclear speck
- membrane
- plasma membrane
- cytoskeleton
- nucleus
- endosome
- vesicle membrane
- nuclear matrix
- presynapse
- postsynapse
- glutamatergic synapse
| Biological process | - G protein-coupled receptor signaling pathway
- thrombin-activated receptor signaling pathway
- response to ATP
- intracellular signal transduction
- phosphorylation
- regulation of transcription by RNA polymerase II
- protein kinase C signaling
- platelet activation
- protein kinase C-activating G protein-coupled receptor signaling pathway
- signal transduction
- glycerolipid metabolic process
- diacylglycerol metabolic process
- lipid phosphorylation
- regulation of gluconeogenesis
- phosphatidic acid biosynthetic process
- activation of transmembrane receptor protein tyrosine kinase activity
- regulation of G protein-coupled receptor signaling pathway
- positive regulation of gene expression
- negative regulation of gene expression
- negative regulation of peptidyl-threonine phosphorylation
- peptidyl-serine phosphorylation
- cAMP-mediated signaling
- positive regulation of peptidyl-tyrosine phosphorylation
- response to cAMP
- regulation of cholesterol metabolic process
- regulation of TORC1 signaling
- regulation of cortisol biosynthetic process
- regulation of progesterone biosynthetic process
- metabolism
- regulation of synaptic vesicle endocytosis
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 4: 0.96 – 0.99 Mb | Chr 5: 108.79 – 108.82 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Diacylglycerol kinase theta is an enzyme that in humans is encoded by the DGKQ gene.[5][6][7]
The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.[7]
Interactions
DGKQ has been shown to interact with RHOA.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000145214 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004815 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Endele S, Zabel B, Winterpacht A (Jun 1996). "Assignment of the human diacylglycerol kinase 4 (DAGK4) gene to chromosome 4p16.3". Genomics. 33 (1): 145–6. doi:10.1006/geno.1996.0174. PMID 8617502.
- ^ Houssa B, Schaap D, van der Wal J, Goto K, Kondo H, Yamakawa A, Shibata M, Takenawa T, van Blitterswijk WJ (May 1997). "Cloning of a novel human diacylglycerol kinase (DGKtheta) containing three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain". J Biol Chem. 272 (16): 10422–8. doi:10.1074/jbc.272.16.10422. PMID 9099683.
- ^ a b "Entrez Gene: DGKQ diacylglycerol kinase, theta 110kDa".
- ^ Houssa, B; de Widt J; Kranenburg O; Moolenaar W H; van Blitterswijk W J (Mar 1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA". J. Biol. Chem. 274 (11): 6820–2. doi:10.1074/jbc.274.11.6820. ISSN 0021-9258. PMID 10066731.
Further reading
- Sakane F, Kanoh H (1998). "Molecules in focus: diacylglycerol kinase". Int. J. Biochem. Cell Biol. 29 (10): 1139–43. doi:10.1016/S1357-2725(97)00037-X. PMID 9438377.
- Li D, Urs AN, Allegood J, et al. (2008). "Cyclic AMP-Stimulated Interaction between Steroidogenic Factor 1 and Diacylglycerol Kinase θ Facilitates Induction of CYP17". Mol. Cell. Biol. 27 (19): 6669–85. doi:10.1128/MCB.00355-07. PMC 2099220. PMID 17664281.
- van Baal J, de Widt J, Divecha N, van Blitterswijk WJ (2005). "Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C". J. Biol. Chem. 280 (11): 9870–8. doi:10.1074/jbc.M409301200. PMID 15632189.
- Tabellini G, Bortul R, Santi S, et al. (2003). "Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus". Exp. Cell Res. 287 (1): 143–54. doi:10.1016/S0014-4827(03)00115-0. PMID 12799190.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Houssa B, de Widt J, Kranenburg O, et al. (1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA". J. Biol. Chem. 274 (11): 6820–2. doi:10.1074/jbc.274.11.6820. PMID 10066731.
- Sakane F, Imai S, Kai M, et al. (1996). "Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases". J. Biol. Chem. 271 (14): 8394–401. doi:10.1074/jbc.271.14.8394. PMID 8626538.