DNA2 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | DNA2, DNA2L, hDNA replication helicase/nuclease 2 |
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External IDs | OMIM: 601810; MGI: 2443732; HomoloGene: 6124; GeneCards: DNA2; OMA:DNA2 - orthologs |
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Gene location (Human) |
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![Chromosome 10 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/2/2f/Ideogram_human_chromosome_10.svg/300px-Ideogram_human_chromosome_10.svg.png) | Chr. | Chromosome 10 (human)[1] |
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| Band | 10q21.3 | Start | 68,414,064 bp[1] |
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End | 68,472,121 bp[1] |
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Gene location (Mouse) |
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![Chromosome 10 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_house_mouse_chromosome_10.svg/260px-Ideogram_house_mouse_chromosome_10.svg.png) | Chr. | Chromosome 10 (mouse)[2] |
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| Band | 10|10 B4 | Start | 62,782,805 bp[2] |
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End | 62,809,964 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - secondary oocyte
- gonad
- testicle
- ventricular zone
- ganglionic eminence
- right lobe of liver
- Epithelium of choroid plexus
- rectum
- trabecular bone
- stromal cell of endometrium
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| Top expressed in | - fetal liver hematopoietic progenitor cell
- primitive streak
- abdominal wall
- otic placode
- epiblast
- otic vesicle
- tibiofemoral joint
- migratory enteric neural crest cell
- mandibular prominence
- medial ganglionic eminence
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/3/3d/PBB_GE_DNA2L_213647_at_fs.png/250px-PBB_GE_DNA2L_213647_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - DNA binding
- 4 iron, 4 sulfur cluster binding
- nucleotide binding
- helicase activity
- iron-sulfur cluster binding
- metal ion binding
- 5'-flap endonuclease activity
- DNA helicase activity
- ATPase activity
- protein binding
- catalytic activity
- 5'-3' DNA helicase activity
- nuclease activity
- endonuclease activity
- site-specific endodeoxyribonuclease activity, specific for altered base
- hydrolase activity
- ATP binding
- single-stranded DNA helicase activity
- RNA binding
| Cellular component | - nucleoplasm
- gamma DNA polymerase complex
- mitochondrial nucleoid
- nucleus
- mitochondrion
- cytoplasm
| Biological process | - mitotic telomere maintenance via semi-conservative replication
- mitochondrial DNA repair
- nucleic acid phosphodiester bond hydrolysis
- DNA double-strand break processing
- mitochondrial DNA replication
- cellular response to DNA damage stimulus
- DNA replication checkpoint signaling
- positive regulation of DNA replication
- metabolism
- base-excision repair
- DNA replication, removal of RNA primer
- DNA replication
- telomere maintenance
- DNA duplex unwinding
- DNA repair
- G-quadruplex DNA unwinding
- t-circle formation
- telomere maintenance via semi-conservative replication
- DNA replication, Okazaki fragment processing
- replication fork reversal
- regulation of signal transduction by p53 class mediator
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 10: 68.41 – 68.47 Mb | Chr 10: 62.78 – 62.81 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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