DTYMK

Protein-coding gene in the species Homo sapiens
DTYMK
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1E9F, 1E9E, 1NMY, 1E2G, 1E9D, 1E98, 1E2E, 1NN0, 1E2Q, 1E9C, 1E2F, 1NN5, 1E99, 2XX3, 1NMZ, 1E9A, 1E2D, 1E9B, 1NMX, 1NN1, 1NN3

Identifiers
AliasesDTYMK, CDC8, PP3731, TMPK, TYMK, deoxythymidylate kinase, CONPM
External IDsOMIM: 188345; MGI: 108396; HomoloGene: 6285; GeneCards: DTYMK; OMA:DTYMK - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for DTYMK
Genomic location for DTYMK
Band2q37.3Start241,675,747 bp[1]
End241,686,944 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for DTYMK
Genomic location for DTYMK
Band1 D|1 47.34 cMStart93,720,298 bp[2]
End93,729,656 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • gonad

  • mucosa of transverse colon

  • ganglionic eminence

  • stromal cell of endometrium

  • right adrenal gland

  • apex of heart

  • granulocyte

  • right adrenal cortex

  • right hemisphere of cerebellum
Top expressed in
  • endocardial cushion

  • renal corpuscle

  • primitive streak

  • medullary collecting duct

  • Paneth cell

  • ureter

  • embryo

  • ventricular zone

  • condyle

  • embryo
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • uridylate kinase activity
  • kinase activity
  • thymidylate kinase activity
  • nucleoside monophosphate kinase activity
  • ATP binding
  • nucleoside diphosphate kinase activity
Cellular component
  • mitochondrial intermembrane space
  • mitochondrial matrix
  • cytoplasm
  • mitochondrion
  • cytosol
  • nucleus
Biological process
  • nucleobase-containing small molecule interconversion
  • nucleotide biosynthetic process
  • response to cadmium ion
  • phosphorylation
  • cellular response to growth factor stimulus
  • dTTP biosynthetic process
  • response to estrogen
  • dTDP biosynthetic process
  • dUDP biosynthetic process
  • myoblast differentiation
  • cell population proliferation
  • nucleoside monophosphate phosphorylation
  • nucleotide phosphorylation
  • nucleoside diphosphate phosphorylation
  • thymidine biosynthetic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1841

21915

Ensembl

ENSG00000168393

ENSMUSG00000026281

UniProt

P23919

P97930

RefSeq (mRNA)
NM_001165031
NM_012145
NM_001320902
NM_001320903
NM_001320904

NM_001320905

NM_001105667
NM_023136

RefSeq (protein)
NP_001158503
NP_001307831
NP_001307832
NP_001307833
NP_001307834

NP_036277

NP_001099137
NP_075625

Location (UCSC)Chr 2: 241.68 – 241.69 MbChr 1: 93.72 – 93.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Thymidylate kinase also known as deoxythymidylate kinase or dTMP kinase is an enzyme that in humans is encoded by the DTYMK gene.[5][6][7] and belongs to thymidylate kinase family of proteins.


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168393 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026281 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Su JY, Sclafani RA (May 1991). "Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast". Nucleic Acids Res. 19 (4): 823–7. doi:10.1093/nar/19.4.823. PMC 333717. PMID 2017365.
  6. ^ Huang SH, Tang A, Drisco B, Zhang SQ, Seeger R, Li C, Jong A (Aug 1994). "Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth". DNA Cell Biol. 13 (5): 461–71. doi:10.1089/dna.1994.13.461. PMID 8024690.
  7. ^ "Entrez Gene: DTYMK deoxythymidylate kinase (thymidylate kinase)".

Further reading

  • Van Rompay AR, Johansson M, Karlsson A (2000). "Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases". Pharmacol. Ther. 87 (2–3): 189–98. doi:10.1016/S0163-7258(00)00048-6. PMID 11008000.
  • Tamiya N, Yusa T, Yamaguchi Y, et al. (1989). "Co-purification of thymidylate kinase and cytosolic thymidine kinase from human term placenta by affinity chromatography". Biochim. Biophys. Acta. 995 (1): 28–35. doi:10.1016/0167-4838(89)90229-X. PMID 2538159.
  • Cummins RR, Balinsky D (1980). "Activities of some enzymes of pyrimidine and DNA synthesis in a rat transplantable hepatoma and human primary hepatomas, in cell lines derived from these tissues, and in human fetal liver". Cancer Res. 40 (4): 1235–9. PMID 6244089.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ostermann N, Segura-Peña D, Meier C, et al. (2003). "Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds". Biochemistry. 42 (9): 2568–77. doi:10.1021/bi027302t. PMID 12614151.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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  • 1e2d: HUMAN THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE, ADENOSINE DIPHOSPHATE AND A MAGNESIUM-ION
    1e2d: HUMAN THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE, ADENOSINE DIPHOSPHATE AND A MAGNESIUM-ION
  • 1e2e: HUMAN THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE, ADENOSINE DIPHOSPHATE,A MAGNESIUM-ION AND ALF3
    1e2e: HUMAN THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE, ADENOSINE DIPHOSPHATE,A MAGNESIUM-ION AND ALF3
  • 1e2f: HUMAN THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE, ADENOSINE DIPHOSPHATE AND A MAGNESIUM-ION
    1e2f: HUMAN THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE, ADENOSINE DIPHOSPHATE AND A MAGNESIUM-ION
  • 1e2g: HUMAN THYMIDYLATE KINASE COMPLEXED WITH ADP, TDP AND A MAGNESIUM-ION
    1e2g: HUMAN THYMIDYLATE KINASE COMPLEXED WITH ADP, TDP AND A MAGNESIUM-ION
  • 1e2q: HUMAN THYMIDYLATE KINASE COMPLEXED WITH TP5A AND A MAGNESIUM-ION
    1e2q: HUMAN THYMIDYLATE KINASE COMPLEXED WITH TP5A AND A MAGNESIUM-ION
  • 1e98: WILD TYPE HUMAN THYMIDYLATE KINASE COMPLEXED WITH AZTMP AND ADP
    1e98: WILD TYPE HUMAN THYMIDYLATE KINASE COMPLEXED WITH AZTMP AND ADP
  • 1e99: HUMAN THYMIDYLATE KINASE COMPLEXED WITH AZTMP AND ADP
    1e99: HUMAN THYMIDYLATE KINASE COMPLEXED WITH AZTMP AND ADP
  • 1e9a: HUMAN THYMIDYLATE KINASE COMPLEXED WITH THE BISUBSTRATE INHIBITOR AZTP5A
    1e9a: HUMAN THYMIDYLATE KINASE COMPLEXED WITH THE BISUBSTRATE INHIBITOR AZTP5A
  • 1e9b: HUMAN THYMIDYLATE KINASE COMPLEXED WITH AZTMP AND APPNP
    1e9b: HUMAN THYMIDYLATE KINASE COMPLEXED WITH AZTMP AND APPNP
  • 1e9c: MUTANT HUMAN THYMIDYLATE KINASE COMPLEXED WITH TMP AND APPNP
    1e9c: MUTANT HUMAN THYMIDYLATE KINASE COMPLEXED WITH TMP AND APPNP
  • 1e9d: MUTANT HUMAN THYMIDYLATE KINASE (F105Y) COMPLEXED WITH AZTMP AND ADP
    1e9d: MUTANT HUMAN THYMIDYLATE KINASE (F105Y) COMPLEXED WITH AZTMP AND ADP
  • 1e9e: MUTANT HUMAN THYMIDYLATE KINASE (F105Y) COMPLEXED WITH DTMP AND ADP
    1e9e: MUTANT HUMAN THYMIDYLATE KINASE (F105Y) COMPLEXED WITH DTMP AND ADP
  • 1e9f: MUTANT HUMAN THYMIDYLATE KINASE COMPLEXED WITH TMP AND ADP
    1e9f: MUTANT HUMAN THYMIDYLATE KINASE COMPLEXED WITH TMP AND ADP
  • 1nmx: Crystal structure of human thymidylate kinase with FLTMP and ADP
    1nmx: Crystal structure of human thymidylate kinase with FLTMP and ADP
  • 1nmy: Crystal structure of human thymidylate kinase with FLTMP and AppNHp
    1nmy: Crystal structure of human thymidylate kinase with FLTMP and AppNHp
  • 1nmz: Crystal structure of human thymidylate kinase with NH2TMP and AppNHp
    1nmz: Crystal structure of human thymidylate kinase with NH2TMP and AppNHp
  • 1nn0: Crystal structure of human thymidylate kinase with ddTMP and ADP
    1nn0: Crystal structure of human thymidylate kinase with ddTMP and ADP
  • 1nn1: Crystal structure of human thymidylate kinase with ddTMP and AppNHp
    1nn1: Crystal structure of human thymidylate kinase with ddTMP and AppNHp
  • 1nn3: Crystal structure of human thymidylate kinase with d4TMP + ADP
    1nn3: Crystal structure of human thymidylate kinase with d4TMP + ADP
  • 1nn5: Crystal structure of human thymidylate kinase with d4TMP + AppNHp
    1nn5: Crystal structure of human thymidylate kinase with d4TMP + AppNHp


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