Dipraglurant
Chemical compound
- None
- 6-Fluoro-2-[4-(2-pyridinyl)-3-butyn-1-yl]imidazo[1,2-a]pyridine
- 872363-17-2
- 44557636
- 25069676
- CV8JZR21A1
- DTXSID90236230
- Interactive image
- c1ccnc(c1)C#CCCc2cn3cc(ccc3n2)F
InChI
- InChI=1S/C16H12FN3/c17-13-8-9-16-19-15(12-20(16)11-13)7-2-1-5-14-6-3-4-10-18-14/h3-4,6,8-12H,2,7H2
- Key:LZXMUJCJAWVHPZ-UHFFFAOYSA-N
Dipraglurant (INN) (code name ADX-48621) is a negative allosteric modulator of the mGlu5 receptor which is under development by Addex Therapeutics for the treatment of Parkinson's disease levodopa-induced dyskinesia (PD-LID).[1][2][3] As of 2014, it is in phase II clinical trials for this indication.[1] Addex Therapeutics is also investigating an extended-release formulation of dipraglurant for the treatment of non-parkinsonian dystonia.[4]
See also
References
- ^ a b Martinez A, Gil C (29 July 2013). Emerging Drugs and Targets for Parkinson's Disease. Royal Society of Chemistry. pp. 255–. ISBN 978-1-84973-617-6.
- ^ Macor JE (2012). Annual Reports in Medicinal Chemistry. Academic Press. pp. 83–. ISBN 978-0-12-396492-2.
- ^ Fox SH, Brotchie JM (8 October 2014). Levodopa-Induced Dyskinesia in Parkinson's Disease. Springer. pp. 323–. ISBN 978-1-4471-6503-3.
- ^ "Dipraglurant-ER for dystonia". Addex Therapeutics. Archived from the original on 2014-12-28. Retrieved 2014-12-28.
External links
- Dipraglurant-IR for Parkinson's disease levodopa-induced dyskinesia - Addex Therapeutics Archived 2014-12-28 at the Wayback Machine
- Dipraglurant-ER for dystonia - Addex Therapeutics Archived 2014-12-28 at the Wayback Machine
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mGluR1Tooltip Metabotropic glutamate receptor 1 |
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mGluR5Tooltip Metabotropic glutamate receptor 5 |
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mGluR2Tooltip Metabotropic glutamate receptor 2 |
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mGluR3Tooltip Metabotropic glutamate receptor 3 |
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mGluR4Tooltip Metabotropic glutamate receptor 4 |
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mGluR6Tooltip Metabotropic glutamate receptor 6 |
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mGluR7Tooltip Metabotropic glutamate receptor 7 | |
mGluR8Tooltip Metabotropic glutamate receptor 8 |
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See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Glutamate metabolism/transport modulators
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