Drugs secreted in the kidney
This is a table of drugs that are secreted in the kidney.
Acid medication are, because of pH partition, secreted to a higher extent when urine is basic. In the same way, basic medications are secreted to a higher extent when urine is acidic.
Medication | Location | Acid or base[1] | anion or cation[2] | Percentage excreted[3] |
---|---|---|---|---|
para-aminohippurate | proximal tubule[4] | Acid | anion | |
furosemide | proximal tubule[4] | Acid | anion | 100-75 |
glucuronic acid-conjugates | proximal tubule[4] | Acid | ||
glycine conjugates | proximal tubule[4] | Acid | ||
indometacin | proximal tubule[4] | Acid | anion | |
methotrexate | proximal tubule[4] | Acid | 100-75 | |
penicillin | proximal tubule[4] | Acid | anion | 75-50 (benzylpenicillin) |
probenecid | proximal tubule[4] | Acid | anion | |
sulphate conjugates | proximal tubule[4] | Acid | ||
thiazide diuretics | proximal tubule[4] | Acid | ||
uric acid | proximal tubule[4] | Acid | ||
amiloride | proximal tubule[4] | Base | cation | |
dopamine | proximal tubule[4] | Base | ||
histamine | proximal tubule[4] | Base | ||
mepacrine | proximal tubule[4] | Base | ||
morphine | proximal tubule[4] | Base | cation | |
pethidine | proximal tubule[4] | Base | ||
quaternary ammonium compounds | proximal tubule[4] | Base | ||
quinine | proximal tubule[4] | Base | cation | |
5-hydroxytryptamine (serotonin) | proximal tubule[4] | Base | ||
triamterene | proximal tubule[4] | Base | ||
gentamicin | 100-75 | |||
atenolol | 100-75 | |||
digoxin | 100-75 | |||
cimetidine | cation | 75-50 | ||
tetracycline | 75-50 (oxytetracycline) | |||
neostigmine | 75-50 | |||
propantheline | ~50 | |||
tubocurarine | ~50 | |||
acetazolamide | proximal tubule[5] | anion | ||
chlorothiazide | proximal tubule[5] | anion | ||
saccharin | proximal tubule[5] | anion | ||
salicylate | proximal tubule[5] | anion | ||
atropine | proximal tubule[5] | cation | ||
NMN | proximal tubule[5] | cation | ||
paraquat | proximal tubule[5] | cation | ||
procainamide | proximal tubule[5] | cation | ||
tetraethylammonium | proximal tubule[5] | cation | ||
chlorpromazine | proximal tubule[5] | cation |
References
- ^ Unless else specified in table boxes, then ref is Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 112
- ^ Unless else specified in table boxes, then ref is Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 802
- ^ Unless else specified in table boxes, then ref is Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 113
- ^ a b c d e f g h i j k l m n o p q r s t u Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 112
- ^ a b c d e f g h i j Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 802
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Secretion | |
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Reabsorption | |
Filtration |
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Hormones | |
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Fluid balance | |
Acid–base balance |