Chemical compound
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Legal status | - In general: ℞ (Prescription only)
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Identifiers |
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CAS Number | - 2400-75-1
58916-73-7 (hydroiodide)
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Chemical and physical data |
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Formula | C10H12N2 |
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Molar mass | 160.220 g·mol−1 |
Echinopsidine (Adepren) is an antidepressant that was under development in Bulgaria for the treatment of depression.[1][2] It increases serotonin, norepinephrine, and dopamine levels in the brain and is believed to act as a monoamine oxidase inhibitor (MAOI).[3][4][5] Echinopsidine is found naturally in Echinops echinatus along with the related alkaloids echinopsine and echinozolinone.[6]
See also
- Monoamine oxidase inhibitor
References
- ^ Guliamov MG (1982). "[Experience with the use of new Bulgarian psychotropic drugs]". Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (in Russian). 82 (11): 115–122. PMID 6758442.
- ^ Guliamov MG (1986). "[Comparative evaluation of the therapeutic efficacy of the antidepressants adepren, linamiphen and emovit]". Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (in Russian). 86 (4): 582–587. PMID 3716711.
- ^ Tiutiulkova N, Gorancheva I (1978). "[Effect of adepren on the cerebral concentration of serotonin]". Eksperimentalna Meditsina I Morfologiia (in Bulgarian). 17 (2): 83–85. PMID 658004.
- ^ Stefanova D, Tiutiulkova N, Nikolova M (1976). "[Effect of adepren on the behavior and brain catecholamines of rats in an open field setup]". Eksperimentalna Meditsina I Morfologiia (in Bulgarian). 15 (1): 42–46. PMID 1269462.
- ^ Tiutiulkova NI, Gorancheva I (1975). "[Excretion of dopamine, noradrenaline, adrenaline, vanilmandelic acid and 5-hydroxyindoleacetic acid in the urine of volunteers treated with adepren]". Eksperimentalna Meditsina I Morfologiia (in Bulgarian). 14 (4): 187–189. PMID 1222713.
- ^ Khare CP (2007). "Echinops echinatus Roxb.". Indian Medicinal Plants An Illustrated Dictionary. Springer-Verlag Berlin Heidelberg. ISBN 978-0-387-70637-5.
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SSRIsTooltip Selective serotonin reuptake inhibitors | |
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SNRIsTooltip Serotonin–norepinephrine reuptake inhibitors | |
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NRIsTooltip Norepinephrine reuptake inhibitors | |
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NDRIsTooltip Norepinephrine–dopamine reuptake inhibitors | |
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NaSSAsTooltip Noradrenergic and specific serotonergic antidepressants | |
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SARIsTooltip Serotonin antagonist and reuptake inhibitors | |
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SMSTooltip Serotonin modulator and stimulators | |
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Others | |
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TCAsTooltip Tricyclic antidepressants | |
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TeCAsTooltip Tetracyclic antidepressants | |
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Others | |
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Non-selective | |
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MAOATooltip Monoamine oxidase A-selective | |
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MAOBTooltip Monoamine oxidase B-selective | |
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Non-specific | AAADTooltip Aromatic L-amino acid decarboxylase | |
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MAOTooltip Monoamine oxidase | |
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Phenethylamines (dopamine, epinephrine, norepinephrine) | PAHTooltip Phenylalanine hydroxylase | |
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THTooltip Tyrosine hydroxylase | - Substrates→Products: Tyrosine→L-DOPA (levodopa)
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DBHTooltip Dopamine beta-monooxygenase | |
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PNMTTooltip Phenylethanolamine N-methyltransferase | - Inhibitors: CGS-19281A
- SKF-64139
- SKF-7698
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COMTTooltip Catechol-O-methyl transferase | |
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Tryptamines (serotonin, melatonin) | TPHTooltip Tryptophan hydroxylase | |
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AANATTooltip Serotonin N-acetyl transferase | |
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ASMTTooltip Acetylserotonin O-methyltransferase | |
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Histamine | HDCTooltip Histidine decarboxylase | |
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HNMTTooltip Histamine N-methyltransferase | - Substrates→Products: Histamine→N-Methylhistamine
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DAOTooltip Diamine oxidase | - Substrates→Products: Histamine→Imidazole acetic acid
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See also: Receptor/signaling modulators • Adrenergics • Dopaminergics • Melatonergics • Serotonergics • Monoamine reuptake inhibitors • Monoamine releasing agents • Monoamine neurotoxins |
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