Protein-coding gene in the species Homo sapiens
FBXW10 |
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Identifiers |
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Aliases | FBXW10, Fbw10, HREP, SM25H2, SM2SH2, F-box and WD repeat domain containing 10 |
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External IDs | OMIM: 611679; MGI: 3052463; HomoloGene: 32757; GeneCards: FBXW10; OMA:FBXW10 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 17 (human)[1] |
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| Band | 17p11.2 | Start | 18,744,026 bp[1] |
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End | 18,779,349 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 11 (mouse)[2] |
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| Band | 11|11 B2 | Start | 62,737,895 bp[2] |
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End | 62,768,291 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - testicle
- left testis
- right testis
- olfactory zone of nasal mucosa
- right uterine tube
- right adrenal cortex
- cerebellar hemisphere
- right hemisphere of cerebellum
- right lobe of liver
- gastrocnemius muscle
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| Top expressed in | - seminiferous tubule
- spermatid
- spermatocyte
- embryo
- zygote
- secondary oocyte
- embryo
- thymus
- primary oocyte
- visual cortex
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - ubiquitin-protein transferase activity
| Cellular component | | Biological process | - protein polyubiquitination
- post-translational protein modification
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001267585 NM_001267586 NM_031456 |
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RefSeq (protein) | | NP_001028841 NP_001278370 NP_001391704 NP_001391705 NP_001391706
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NP_001391707 |
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Location (UCSC) | Chr 17: 18.74 – 18.78 Mb | Chr 11: 62.74 – 62.77 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene.[5][6][7]
Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).[supplied by OMIM][7] Increased expression of the gene has been associated with laminopathies, and in degradation of chromatin associated proteins such as HP1, ATR kinases (Chaturvedi and ParnaiK, 2010, PMID 20498703).
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000171931 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090173 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kennerson ML, Nassif NT, Nicholson GA (Dec 1998). "Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat". Genomics. 53 (1): 110–2. doi:10.1006/geno.1998.5453. PMID 9787083.
- ^ Kennerson ML, Gordon MJ, Blair IP, Nicholson GA (Dec 1995). "Single test for two hereditary neuropathies, CMT1A and HNPP". Clin Chem. 41 (10): 1534–5. doi:10.1093/clinchem/41.10.1534. PMID 7586531.
- ^ a b "Entrez Gene: FBXW10 F-box and WD repeat domain containing 10".
Further reading
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Jin J, Cardozo T, Lovering RC, et al. (2005). "Systematic analysis and nomenclature of mammalian F-box proteins". Genes Dev. 18 (21): 2573–80. doi:10.1101/gad.1255304. PMC 525538. PMID 15520277.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.