FBXW10

Protein-coding gene in the species Homo sapiens
FBXW10
Identifiers
AliasesFBXW10, Fbw10, HREP, SM25H2, SM2SH2, F-box and WD repeat domain containing 10
External IDsOMIM: 611679; MGI: 3052463; HomoloGene: 32757; GeneCards: FBXW10; OMA:FBXW10 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for FBXW10
Genomic location for FBXW10
Band17p11.2Start18,744,026 bp[1]
End18,779,349 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for FBXW10
Genomic location for FBXW10
Band11|11 B2Start62,737,895 bp[2]
End62,768,291 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • left testis

  • right testis

  • olfactory zone of nasal mucosa

  • right uterine tube

  • right adrenal cortex

  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • right lobe of liver

  • gastrocnemius muscle
Top expressed in
  • seminiferous tubule

  • spermatid

  • spermatocyte

  • embryo

  • zygote

  • secondary oocyte

  • embryo

  • thymus

  • primary oocyte

  • visual cortex
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • ubiquitin-protein transferase activity
Cellular component
  • cytosol
Biological process
  • protein polyubiquitination
  • post-translational protein modification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10517

213980

Ensembl

ENSG00000171931

ENSMUSG00000090173

UniProt

Q5XX13

Q5SUS0

RefSeq (mRNA)

NM_001267585
NM_001267586
NM_031456

NM_001033669
NM_001291441

RefSeq (protein)

NP_001254514
NP_001254515

NP_001028841
NP_001278370
NP_001391704
NP_001391705
NP_001391706

NP_001391707

Location (UCSC)Chr 17: 18.74 – 18.78 MbChr 11: 62.74 – 62.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene.[5][6][7]

Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).[supplied by OMIM][7] Increased expression of the gene has been associated with laminopathies, and in degradation of chromatin associated proteins such as HP1, ATR kinases (Chaturvedi and ParnaiK, 2010, PMID 20498703).


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171931 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090173 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kennerson ML, Nassif NT, Nicholson GA (Dec 1998). "Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat". Genomics. 53 (1): 110–2. doi:10.1006/geno.1998.5453. PMID 9787083.
  6. ^ Kennerson ML, Gordon MJ, Blair IP, Nicholson GA (Dec 1995). "Single test for two hereditary neuropathies, CMT1A and HNPP". Clin Chem. 41 (10): 1534–5. doi:10.1093/clinchem/41.10.1534. PMID 7586531.
  7. ^ a b "Entrez Gene: FBXW10 F-box and WD repeat domain containing 10".

Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Jin J, Cardozo T, Lovering RC, et al. (2005). "Systematic analysis and nomenclature of mammalian F-box proteins". Genes Dev. 18 (21): 2573–80. doi:10.1101/gad.1255304. PMC 525538. PMID 15520277.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.