Protein-coding gene in the species Homo sapiens
FBXW5 |
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Identifiers |
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Aliases | FBXW5, Fbw5, F-box and WD repeat domain containing 5 |
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External IDs | OMIM: 609072; MGI: 1354731; HomoloGene: 8496; GeneCards: FBXW5; OMA:FBXW5 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 9 (human)[1] |
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| Band | 9q34.3 | Start | 136,940,435 bp[1] |
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End | 136,944,738 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 2 (mouse)[2] |
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| Band | 2|2 A3 | Start | 25,390,762 bp[2] |
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End | 25,395,483 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - right testis
- left testis
- apex of heart
- popliteal artery
- tibial arteries
- muscle of thigh
- gastrocnemius muscle
- granulocyte
- right lobe of liver
- right coronary artery
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| Top expressed in | - spermatocyte
- spermatid
- seminiferous tubule
- muscle of thigh
- entorhinal cortex
- superior frontal gyrus
- primary visual cortex
- saccule
- perirhinal cortex
- right kidney
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - protein binding
- protein kinase binding
- ubiquitin-protein transferase activity
| Cellular component | - Cul4-RING E3 ubiquitin ligase complex
- cytoplasm
- SCF ubiquitin ligase complex
- cytosol
| Biological process | - proteasome-mediated ubiquitin-dependent protein catabolic process
- protein ubiquitination
- regulation of centrosome duplication
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- protein polyubiquitination
- regulation of mitotic nuclear division
- post-translational protein modification
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_018998 NM_178225 NM_178226 |
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NM_013908 NM_001356407 NM_001356408 |
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RefSeq (protein) | | |
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NP_038936 NP_001343336 NP_001343337 |
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Location (UCSC) | Chr 9: 136.94 – 136.94 Mb | Chr 2: 25.39 – 25.4 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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F-box/WD repeat-containing protein 5 is a protein that in humans is encoded by the FBXW5 gene.[5]
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated Messenger RNA decay candidates, hence not represented.[5] Well established targets of FBXW5 include TSC2[6] and SEC23B.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000159069 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015095 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: FBXW5 F-box and WD repeat domain containing 5".
- ^ Hu J, Zacharek S, He YJ, Lee H, Shumway S, Duronio RJ, et al. (April 2008). "WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase". Genes & Development. 22 (7): 866–71. doi:10.1101/gad.1624008. PMC 2279197. PMID 18381890.
- ^ Jeong YT, Simoneschi D, Keegan S, Melville D, Adler NS, Saraf A, et al. (December 2018). "The ULK1-FBXW5-SEC23B nexus controls autophagy". eLife. 7. doi:10.7554/eLife.42253. PMC 6351106. PMID 30596474.
Further reading
- Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Current Biology. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
- Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (October 1999). "A family of mammalian F-box proteins". Current Biology. 9 (20): 1180–2. Bibcode:1999CBio....9.1180W. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
- Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T, et al. (March 2004). "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP". Proceedings of the National Academy of Sciences of the United States of America. 101 (13): 4419–24. Bibcode:2004PNAS..101.4419W. doi:10.1073/pnas.0307700101. PMC 384762. PMID 15070733.