FCF1

Protein-coding gene in the species Homo sapiens
FCF1
Identifiers
AliasesFCF1, Bka, C14orf111, UTP24, CGI-35, FCF1 rRNA-processing protein, rRNA-processing protein
External IDsMGI: 1920986; HomoloGene: 5706; GeneCards: FCF1; OMA:FCF1 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for FCF1
Genomic location for FCF1
Band14q24.3Start74,713,144 bp[1]
End74,738,620 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for FCF1
Genomic location for FCF1
Band12|12 D1Start85,017,671 bp[2]
End85,030,077 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • germinal epithelium

  • rectum

  • monocyte

  • amniotic fluid

  • islet of Langerhans

  • mucosa of paranasal sinus

  • gingival epithelium

  • stromal cell of endometrium

  • Achilles tendon

  • palpebral conjunctiva
Top expressed in
  • primary oocyte

  • yolk sac

  • morula

  • epiblast

  • embryo

  • embryo

  • secondary oocyte

  • blastocyst

  • genital tubercle

  • tail of embryo
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • RNA binding
Cellular component
  • small-subunit processome
  • nucleolus
  • nucleus
  • nucleoplasm
Biological process
  • ribosome biogenesis
  • rRNA processing
  • endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51077

73736

Ensembl

ENSG00000119616

ENSMUSG00000021243

UniProt

Q9Y324

Q9CTH6

RefSeq (mRNA)

NM_015962
NM_001318508

NM_028632

RefSeq (protein)

NP_001305437
NP_057046

NP_082908

Location (UCSC)Chr 14: 74.71 – 74.74 MbChr 12: 85.02 – 85.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

rRNA-processing protein FCF1 homolog is a protein that in humans is encoded by the FCF1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119616 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021243 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Rempola B, Karkusiewicz I, Piekarska I, Rytka J (Jun 2006). "Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing". Biochem Biophys Res Commun. 346 (2): 546–54. doi:10.1016/j.bbrc.2006.05.140. PMID 16762320.
  6. ^ "Entrez Gene: FCF1 FCF1 small subunit (SSU) processome component homolog (S. cerevisiae)".

Further reading

  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Wellenreuther R, Schupp I, Poustka A, et al. (2004). "SMART amplification combined with cDNA size fractionation in order to obtain large full-length clones". BMC Genomics. 5 (1): 36. doi:10.1186/1471-2164-5-36. PMC 436056. PMID 15198809.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. Bibcode:2003Natur.421..601H. doi:10.1038/nature01348. PMID 12508121.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.


  • v
  • t
  • e