FCHSD2

Protein-coding gene in the species Homo sapiens

FCHSD2

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2DL5, 2DL7

Identifiers

Aliases

FCHSD2, NWK, SH3MD3, FCH and double SH3 domains 2, NWK1

External IDs

OMIM: 617556; MGI: 2448475; HomoloGene: 8887; GeneCards: FCHSD2; OMA:FCHSD2 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q13.4	Start	72,836,745 bp^[1]
Band	11q13.4	End	73,142,318 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 E2	Start	100,742,070 bp^[2]
Band	7\|7 E2	End	100,933,612 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

popliteal artery

tibial arteries

lymph node

right coronary artery

Descending thoracic aorta

ascending aorta

ventricular zone

right lung

left coronary artery

appendix

Top expressed in

zygote

mesenteric lymph nodes

secondary oocyte

primary oocyte

habenula

paraventricular nucleus of hypothalamus

otolith organ

trigeminal ganglion

utricle

epithelium of small intestine

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding phosphatidylinositol-3,4,5-trisphosphate binding phosphatidylinositol-3,4-bisphosphate binding lipid binding
Cellular component	neuromuscular junction recycling endosome plasma membrane clathrin-coated pit stereocilium shaft cytoplasm membrane cell junction stereocilium cell projection
Biological process	neuromuscular synaptic transmission regulation of actin filament polymerization positive regulation of actin filament polymerization clathrin-dependent endocytosis positive regulation of Arp2/3 complex-mediated actin nucleation endocytosis protein transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9873


207278

Ensembl


ENSG00000137478


ENSMUSG00000030691

UniProt


O94868


Q3USJ8

RefSeq (mRNA)


NM_014824


NM_001146010 NM_199012

RefSeq (protein)


NP_055639


NP_001139482 NP_950177

Location (UCSC)

Chr 11: 72.84 – 73.14 Mb

Chr 7: 100.74 – 100.93 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

FCH and double SH3 domains protein 2 is a protein that in humans is encoded by the FCHSD2 gene.^[5]^[6]^[7]

Interactions

FCHSD2 has been shown to interact with MAGI1^[8] and C2orf73.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137478 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030691 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
^ Katoh M, Katoh M (May 2004). "Identification and characterization of human FCHSD1 and FCHSD2 genes in silico". International Journal of Molecular Medicine. 13 (5): 749–54. doi:10.3892/ijmm.13.5.749. PMID 15067381.
^ "Entrez Gene: FCHSD2 FCH and double SH3 domains 2".
^ Ohno H, Hirabayashi S, Kansaku A, Yao I, Tajima M, Nishimura W, Ohnishi H, Mashima H, Fujita T, Omata M, Hata Y (November 2003). "Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains". Oncogene. 22 (52): 8422–31. doi:10.1038/sj.onc.1206996. PMID 14627983. S2CID 6289557.
^ Thalappilly S, Suliman M, Gayet O, Soubeyran P, Hermant A, Lecine P, Iovanna JL, Dusetti NJ (August 2008). "Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach". Proteomics. 8 (15): 3071–81. doi:10.1002/pmic.200701157. PMID 18654987. S2CID 25344443.

Petitjean C, Scheydeker JL, Suinat JL, Rendoing J (1976). "[Pulmonary edema in hangings]". De l'Anesthésiologie Française. 16. 16 Spec No 2-3: 57–65. PMID 9873.
Ohno H, Hirabayashi S, Kansaku A, Yao I, Tajima M, Nishimura W, Ohnishi H, Mashima H, Fujita T, Omata M, Hata Y (November 2003). "Carom: a novel membrane-associated guanylate kinase-interacting protein with two SH3 domains". Oncogene. 22 (52): 8422–31. doi:10.1038/sj.onc.1206996. PMID 14627983. S2CID 6289557.
Coyle IP, Koh YH, Lee WC, Slind J, Fergestad T, Littleton JT, Ganetzky B (February 2004). "Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in Drosophila". Neuron. 41 (4): 521–34. doi:10.1016/S0896-6273(04)00016-9. PMID 14980202. S2CID 797812.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y (March 2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature. 440 (7083): 497–500. Bibcode:2006Natur.440..497T. doi:10.1038/nature04632. PMID 16554811.