FREM1

Protein-coding gene in the species Homo sapiens
FREM1
Identifiers
AliasesFREM1, BNAR, C9orf143, C9orf145, C9orf154, MOTA, TILRR, TRIGNO2, FRAS1 related extracellular matrix 1
External IDsOMIM: 608944; MGI: 2670972; HomoloGene: 27049; GeneCards: FREM1; OMA:FREM1 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for FREM1
Genomic location for FREM1
Band9p22.3Start14,737,152 bp[1]
End14,910,995 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for FREM1
Genomic location for FREM1
Band4|4 C3Start82,816,157 bp[2]
End82,970,576 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • smooth muscle tissue

  • metanephros

  • body of uterus

  • right hemisphere of cerebellum

  • Descending thoracic aorta

  • ascending aorta

  • body of pancreas

  • popliteal artery

  • tibial arteries

  • right coronary artery
Top expressed in
  • left lung lobe

  • Epithelium of choroid plexus

  • otolith organ

  • utricle

  • vas deferens

  • Gonadal ridge

  • retinal pigment epithelium

  • vestibular membrane of cochlear duct

  • ciliary body

  • dermis
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • metal ion binding
  • carbohydrate binding
Cellular component
  • integral component of membrane
  • extracellular region
  • basement membrane
Biological process
  • multicellular organism development
  • cell communication
  • cell-matrix adhesion
  • cell adhesion
  • craniofacial suture morphogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

158326

329872

Ensembl

ENSG00000164946

ENSMUSG00000059049

UniProt

Q5H8C1

Q684R7

RefSeq (mRNA)
NM_001177704
NM_144966
NM_001370058
NM_001370060
NM_001370061

NM_001370063
NM_001370065
NM_001379081

NM_001198811
NM_177863

RefSeq (protein)
NP_001171175
NP_659403
NP_001356987
NP_001356989
NP_001356990

NP_001356992
NP_001356994
NP_001366010

NP_001185740
NP_808531

Location (UCSC)Chr 9: 14.74 – 14.91 MbChr 4: 82.82 – 82.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FRAS1-related extracellular matrix protein 1 is a protein that in humans is encoded by the FREM1 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164946 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059049 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
  6. ^ Smyth I, Du X, Taylor MS, Justice MJ, Beutler B, Jackson IJ (Sep 2004). "The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis". Proc Natl Acad Sci U S A. 101 (37): 13560–5. Bibcode:2004PNAS..10113560S. doi:10.1073/pnas.0402760101. PMC 518794. PMID 15345741.
  7. ^ "Entrez Gene: FREM1 FRAS1 related extracellular matrix 1".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kiyozumi D, Osada A, Sugimoto N, et al. (2005). "Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle". Exp. Cell Res. 306 (1): 9–23. doi:10.1016/j.yexcr.2005.01.020. PMID 15878328.
  • GeneReviews/NCBI/NIH/UW entry on Manitoba Oculotrichoanal Syndrome, Marles Syndrome, MOTA Syndrome


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