Ferroxidase
Iron oxidizing enzyme, Fe(II) to Fe(III) conversion
Ferroxidase | |||||||||
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Identifiers | |||||||||
EC no. | 1.16.3.1 | ||||||||
CAS no. | 9031-37-2 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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Ferroxidase also known as Fe(II):oxygen oxidoreductase is an enzyme that catalyzes the oxidization of iron II to iron III:
- 4 Fe2+ + 4 H+ + O2 ⇔ 4 Fe3+ + 2H2O
Examples
Human genes encoding proteins with ferroxidase activity include:
- CP – Ceruloplasmin
- FTH1 – Ferritin heavy chain
- FTMT – Ferritin, mitochondrial
- HEPH - Hephaestin
References
- Cox JC, Boxer DH (1986). "The role of rusticyanin, a blue copper protein, in the electron transport chain of Thiobacillus ferrooxidans grown on iron or thiosulfate". Biotechnol. Appl. Biochem. 8: 269–275.
- Osaki S (November 1966). "Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase (ceruloplasmin)". J. Biol. Chem. 241 (21): 5053–9. doi:10.1016/S0021-9258(18)99669-9. PMID 5925868.
- Osaki S, Walaas O (June 1967). "Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase. II. Rate constants at various steps and formation of a possible enzyme-substrate complex". J. Biol. Chem. 242 (11): 2653–7. doi:10.1016/S0021-9258(18)99620-1. PMID 6027241.
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Other oxidoreductases (EC 1.15–1.21)
- Ceruloplasmin
- (Methionine synthase) reductase
- Nitrogenase (flavodoxin)
- Isopenicillin N synthase
- Columbamine oxidase
- Reticuline oxidase
- Sulochrin oxidase
- (+)-bisdechlorogeodin-forming
- (-)-bisdechlorogeodin-forming
- Aureusidin synthase
- Tetrahydrocannabinolic acid synthase
- Cannabidiolic acid synthase
- Dichlorochromopyrrolate synthase
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