Protein that is encoded by the GRAMD4 gene
GRAMD4 |
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Identifiers |
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Aliases | GRAMD4, DIP, dA59H18.1, dJ439F8.1, GRAM domain containing 4 |
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External IDs | OMIM: 613691; MGI: 2676308; HomoloGene: 18199; GeneCards: GRAMD4; OMA:GRAMD4 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 22 (human)[1] |
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| Band | 22q13.31 | Start | 46,576,012 bp[1] |
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End | 46,679,790 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 15 (mouse)[2] |
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| Band | 15|15 E2 | Start | 85,941,896 bp[2] |
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End | 86,021,835 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - mucosa of transverse colon
- right lobe of liver
- apex of heart
- sural nerve
- ventricular zone
- monocyte
- ganglionic eminence
- left ventricle
- right auricle
- skin of abdomen
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| Top expressed in | - interventricular septum
- pyloric antrum
- epithelium of stomach
- trigeminal ganglion
- ventricular zone
- mesenteric lymph nodes
- ganglionic eminence
- superior cervical ganglion
- Rostral migratory stream
- mucous cell of stomach
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | | Cellular component | - mitochondrial membranes
- integral component of membrane
- membrane
- mitochondrion
- endoplasmic reticulum
- endoplasmic reticulum membrane
| Biological process | - apoptotic process
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of toll-like receptor 9 signaling pathway
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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NM_001205353 NM_172611 NM_001379572 |
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RefSeq (protein) | | |
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NP_001192282 NP_766199 NP_001366501 |
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Location (UCSC) | Chr 22: 46.58 – 46.68 Mb | Chr 15: 85.94 – 86.02 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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GRAM domain containing 4 (GRAMD4) also known as Death-Inducing Protein (DIP) is a protein that is encoded by the GRAMD4 gene.[5][6]
Function
GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000075240 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035900 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: GRAM domain containing 4". Retrieved 2017-05-16.
- ^ "RecName: Full=GRAM domain-containing protein 4; AltName: Full=Death-inducing protein". Retrieved 2020-03-07.
- ^ Stanelle J, Tu-Rapp H, Pützer BM (2005). "A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53". Cell Death Differ. 12 (4): 347–57. doi:10.1038/sj.cdd.4401532. PMID 15565177. S2CID 24578301.
Further reading
- Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
- John K, Alla V, Meier C, Pützer BM (2011). "GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria". Cell Death Differ. 18 (5): 874–86. doi:10.1038/cdd.2010.153. PMC 3131914. PMID 21127500.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.