GRAMD4

Protein that is encoded by the GRAMD4 gene
GRAMD4
Identifiers
AliasesGRAMD4, DIP, dA59H18.1, dJ439F8.1, GRAM domain containing 4
External IDsOMIM: 613691; MGI: 2676308; HomoloGene: 18199; GeneCards: GRAMD4; OMA:GRAMD4 - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for GRAMD4
Genomic location for GRAMD4
Band22q13.31Start46,576,012 bp[1]
End46,679,790 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for GRAMD4
Genomic location for GRAMD4
Band15|15 E2Start85,941,896 bp[2]
End86,021,835 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • right lobe of liver

  • apex of heart

  • sural nerve

  • ventricular zone

  • monocyte

  • ganglionic eminence

  • left ventricle

  • right auricle

  • skin of abdomen
Top expressed in
  • interventricular septum

  • pyloric antrum

  • epithelium of stomach

  • trigeminal ganglion

  • ventricular zone

  • mesenteric lymph nodes

  • ganglionic eminence

  • superior cervical ganglion

  • Rostral migratory stream

  • mucous cell of stomach
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • molecular function
Cellular component
  • mitochondrial membranes
  • integral component of membrane
  • membrane
  • mitochondrion
  • endoplasmic reticulum
  • endoplasmic reticulum membrane
Biological process
  • apoptotic process
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
  • negative regulation of toll-like receptor 9 signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23151

223752

Ensembl

ENSG00000075240

ENSMUSG00000035900

UniProt

Q6IC98

Q8CB44

RefSeq (mRNA)

NM_015124
NM_001366660

NM_001205353
NM_172611
NM_001379572

RefSeq (protein)

NP_055939
NP_001353589

NP_001192282
NP_766199
NP_001366501

Location (UCSC)Chr 22: 46.58 – 46.68 MbChr 15: 85.94 – 86.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GRAM domain containing 4 (GRAMD4) also known as Death-Inducing Protein (DIP) is a protein that is encoded by the GRAMD4 gene.[5][6]

Function

GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000075240 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035900 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: GRAM domain containing 4". Retrieved 2017-05-16.
  6. ^ "RecName: Full=GRAM domain-containing protein 4; AltName: Full=Death-inducing protein". Retrieved 2020-03-07.
  7. ^ Stanelle J, Tu-Rapp H, Pützer BM (2005). "A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53". Cell Death Differ. 12 (4): 347–57. doi:10.1038/sj.cdd.4401532. PMID 15565177. S2CID 24578301.

Further reading

  • Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
  • John K, Alla V, Meier C, Pützer BM (2011). "GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria". Cell Death Differ. 18 (5): 874–86. doi:10.1038/cdd.2010.153. PMC 3131914. PMID 21127500.


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.