HLA-DOA

Protein-coding gene in the species Homo sapiens

HLA-DOA

Available structures

PDB

Human UniProt search: PDBe RCSB

List of PDB id codes
4I0P

Identifiers

Aliases

HLA-DOA, HLA-DNA, HLA-DZA, HLADZ, major histocompatibility complex, class II, DO alpha

External IDs

OMIM: 142930; MGI: 95924; HomoloGene: 1601; GeneCards: HLA-DOA; OMA:HLA-DOA - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6p21.32	Start	33,004,182 bp^[1]
Band	6p21.32	End	33,009,591 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	17 B1\|17 17.98 cM	Start	34,311,314 bp^[2]
Band	17 B1\|17 17.98 cM	End	34,314,208 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

lymph node

appendix

granulocyte

spleen

gallbladder

monocyte

blood

tonsil

upper lobe of left lung

right lung

Top expressed in

mesenteric lymph nodes

spleen

blood

thymus

morula

submandibular gland

subcutaneous adipose tissue

embryo

primary oocyte

embryo

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	MHC class II receptor activity protein binding MHC class II protein complex binding
Cellular component	integral component of membrane lysosomal membrane endosome plasma membrane lysosome MHC class II protein complex endosome membrane membrane
Biological process	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II immune response negative regulation of antigen processing and presentation of peptide antigen via MHC class II regulation of T cell differentiation immune system process signal transduction adaptive immune response
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3111


15001

Ensembl

ENSG00000204252 ENSG00000230141 ENSG00000232962 ENSG00000235744 ENSG00000231558
ENSG00000206292 ENSG00000232957


ENSMUSG00000024334

UniProt


P06340


n/a

RefSeq (mRNA)


NM_002119 NM_015851


NM_008206

RefSeq (protein)


NP_002110


n/a

Location (UCSC)

Chr 6: 33 – 33.01 Mb

Chr 17: 34.31 – 34.31 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

HLA class II histocompatibility antigen, DO alpha chain is a protein that in humans is encoded by the HLA-DOA gene.^[5]^[6]

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.^[6]

References

^ ^a ^b ^c ENSG00000230141, ENSG00000232962, ENSG00000235744, ENSG00000231558, ENSG00000206292, ENSG00000232957 GRCh38: Ensembl release 89: ENSG00000204252, ENSG00000230141, ENSG00000232962, ENSG00000235744, ENSG00000231558, ENSG00000206292, ENSG00000232957 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024334 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Young JA, Trowsdale J (Aug 1990). "The HLA-DNA (DZA) gene is correctly expressed as a 1.1 kb mature mRNA transcript". Immunogenetics. 31 (5–6): 386–8. doi:10.1007/BF02115015. PMID 2370084. S2CID 31652916.
^ ^a ^b "Entrez Gene: HLA-DOA major histocompatibility complex, class II, DO alpha".

Piatier-Tonneau D, Gastinel LN, Amblard F, et al. (1991). "Interaction of CD4 with HLA class II antigens and HIV gp120". Immunogenetics. 34 (2): 121–8. doi:10.1007/BF00211424. PMID 1869305. S2CID 10116507.
Rosenstein Y, Burakoff SJ, Herrmann SH (1990). "HIV-gp120 can block CD4-class II MHC-mediated adhesion". J. Immunol. 144 (2): 526–31. doi:10.4049/jimmunol.144.2.526. PMID 1967269.
Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ (1991). "Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 9052–6. doi:10.1073/pnas.87.22.9052. PMC 55099. PMID 1978941.
Rosen-Bronson S, Long EO (1991). "An unusual form of alternative splicing in the HLA-DNA gene". Immunogenetics. 33 (2): 124–31. doi:10.1007/BF00210826. PMID 1999352. S2CID 23451770.
Jonsson AK, Rask L (1989). "Human class II DNA and DOB genes display low sequence variability". Immunogenetics. 29 (6): 411–3. doi:10.1007/BF00375872. PMID 2499532. S2CID 5481750.
Clayton LK, Sieh M, Pious DA, Reinherz EL (1989). "Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding". Nature. 339 (6225): 548–51. Bibcode:1989Natur.339..548C. doi:10.1038/339548a0. PMID 2543930. S2CID 4246781.
Diamond DC, Sleckman BP, Gregory T, et al. (1988). "Inhibition of CD4+ T cell function by the HIV envelope protein, gp120". J. Immunol. 141 (11): 3715–7. doi:10.4049/jimmunol.141.11.3715. PMID 2846691.
Inoko H, Ando A, Kimura M, Tsuji K (1985). "Isolation and characterization of the cDNA clone and genomic clones of a new HLA class II antigen heavy chain, DO alpha". J. Immunol. 135 (3): 2156–9. doi:10.4049/jimmunol.135.3.2156. PMID 2991382.
Trowsdale J, Kelly A (1986). "The human HLA class II alpha chain gene DZ alpha is distinct from genes in the DP, DQ and DR subregions". EMBO J. 4 (9): 2231–7. doi:10.1002/j.1460-2075.1985.tb03919.x. PMC 554490. PMID 3000765.
Andrieu JM, Even P, Venet A (1986). "AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications". AIDS Research. 2 (3): 163–74. doi:10.1089/aid.1.1986.2.163. PMID 3489470.
Houlgatte R, Scarmato P, el Marhomy S, et al. (1994). "HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4". J. Immunol. 152 (9): 4475–88. doi:10.4049/jimmunol.152.9.4475. PMID 7512597.
Chirmule N, McCloskey TW, Hu R, et al. (1995). "HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71)". J. Immunol. 155 (2): 917–24. doi:10.4049/jimmunol.155.2.917. PMID 7541827.
Rowell JF, Stanhope PE, Siliciano RF (1995). "Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC". J. Immunol. 155 (1): 473–88. doi:10.4049/jimmunol.155.1.473. PMID 7602119. S2CID 19994352.
Chen YH, Böck G, Vornhagen R, et al. (1994). "HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41". Mol. Immunol. 31 (13): 977–82. doi:10.1016/0161-5890(94)90092-2. PMID 8084338.
Chirmule N, Wang XP, Hu R, et al. (1994). "Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help". Cell. Immunol. 155 (1): 169–82. doi:10.1006/cimm.1994.1110. PMID 8168144.
Callahan KM, Rowell JF, Soloski MJ, et al. (1993). "HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes". J. Immunol. 151 (6): 2928–42. doi:10.4049/jimmunol.151.6.2928. PMID 8376762.
Liljedahl M, Kuwana T, Fung-Leung WP, et al. (1996). "HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport". EMBO J. 15 (18): 4817–24. doi:10.1002/j.1460-2075.1996.tb00862.x. PMC 452218. PMID 8890155.
Ruff AL, Guarnieri FG, Staveley-O'Carroll K, et al. (1997). "The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway". J. Biol. Chem. 272 (13): 8671–8. doi:10.1074/jbc.272.13.8671. PMID 9079699.
Douek DC, Altmann DM (1997). "HLA-DO is an intracellular class II molecule with distinctive thymic expression". Int. Immunol. 9 (3): 355–64. doi:10.1093/intimm/9.3.355. PMID 9088974.