HS2ST1

Enzyme
HS2ST1
Identifiers
AliasesHS2ST1, dJ604K5.2, heparan sulfate 2-O-sulfotransferase 1, NFSRA
External IDsOMIM: 604844; MGI: 1346049; HomoloGene: 8025; GeneCards: HS2ST1; OMA:HS2ST1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for HS2ST1
Genomic location for HS2ST1
Band1p22.3Start86,914,635 bp[1]
End87,109,982 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for HS2ST1
Genomic location for HS2ST1
Band3|3 H2Start144,135,467 bp[2]
End144,275,942 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • germinal epithelium

  • endothelial cell

  • right adrenal cortex

  • left adrenal gland

  • Epithelium of choroid plexus

  • left adrenal cortex

  • ventricular zone

  • stromal cell of endometrium

  • retinal pigment epithelium
Top expressed in
  • right lung

  • left lung

  • right lung lobe

  • left lung lobe

  • medial ganglionic eminence

  • endothelial cell of lymphatic vessel

  • vestibular sensory epithelium

  • ciliary body

  • secondary oocyte

  • iris
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transferase activity
  • sulfotransferase activity
  • heparan sulfate 2-O-sulfotransferase activity
Cellular component
  • integral component of membrane
  • Golgi membrane
  • Golgi apparatus
  • membrane
Biological process
  • glycosaminoglycan biosynthetic process
  • heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
  • heparan sulfate proteoglycan biosynthetic process, enzymatic modification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9653

23908

Ensembl

ENSG00000153936

ENSMUSG00000040151

UniProt

Q7LGA3

Q8R3H7

RefSeq (mRNA)

NM_012262
NM_001134492

NM_011828
NM_001355234

RefSeq (protein)

NP_001127964
NP_036394

NP_035958
NP_001342163

Location (UCSC)Chr 1: 86.91 – 87.11 MbChr 3: 144.14 – 144.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Heparan sulfate 2-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS2ST1 gene.[5][6]

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes heparan sulfate 2-O-sulfotransferase, a member of the heparan sulfate biosynthetic enzyme family. This family member transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate.

The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153936 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040151 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Feb 1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
  6. ^ a b "Entrez Gene: HS2ST1 heparan sulfate 2-O-sulfotransferase 1".

Further reading

  • Muramatsu T (2000). "Essential roles of carbohydrate signals in development, immune response and tissue functions, as revealed by gene targeting". J. Biochem. 127 (2): 171–6. doi:10.1093/oxfordjournals.jbchem.a022590. PMID 10731680.
  • Rong J, Habuchi H, Kimata K, et al. (2000). "Expression of heparan sulphate L-iduronyl 2-O-sulphotransferase in human kidney 293 cells results in increased D-glucuronyl 2-O-sulphation". Biochem. J. 346 (2): 463–8. doi:10.1042/0264-6021:3460463. PMC 1220874. PMID 10677367.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Aquino RS, Landeira-Fernandez AM, Valente AP, et al. (2005). "Occurrence of sulfated galactans in marine angiosperms: evolutionary implications". Glycobiology. 15 (1): 11–20. doi:10.1093/glycob/cwh138. PMID 15317737.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Xu D, Song D, Pedersen LC, Liu J (2007). "Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase". J. Biol. Chem. 282 (11): 8356–67. doi:10.1074/jbc.M608062200. PMID 17227754.


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