Protein-coding gene in the species Homo sapiens
| HS6ST2 |
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| Identifiers |
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| Aliases | HS6ST2, heparan sulfate 6-O-sulfotransferase 2, MRXSPM |
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| External IDs | OMIM: 300545; MGI: 1354959; HomoloGene: 9277; GeneCards: HS6ST2; OMA:HS6ST2 - orthologs |
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| Gene location (Human) |
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 | | Chr. | X chromosome (human)[1] |
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| | Band | Xq26.2 | Start | 132,626,015 bp[1] |
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| End | 132,961,395 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | X chromosome (mouse)[2] |
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| | Band | X|X A5 | Start | 50,476,089 bp[2] |
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| End | 50,770,733 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - endothelial cell
- Brodmann area 23
- lateral nuclear group of thalamus
- renal medulla
- testicle
- middle temporal gyrus
- placenta
- ventricular zone
- entorhinal cortex
- Brodmann area 46
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| | Top expressed in | - Epithelium of choroid plexus
- lateral septal nucleus
- Gonadal ridge
- lateral hypothalamus
- dorsomedial hypothalamic nucleus
- calvaria
- nucleus accumbens
- habenula
- dorsal striatum
- superior colliculus
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| | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | - transferase activity
- sulfotransferase activity
- heparan sulfate 6-O-sulfotransferase activity
| | Cellular component | - integral component of membrane
- Golgi membrane
- membrane
- nucleoplasm
| | Biological process | - heparan sulfate proteoglycan biosynthetic process, enzymatic modification
- glycosaminoglycan biosynthetic process
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | |
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NM_001077188
NM_147175
NM_001394073
NM_001394074
NM_147174 |
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NM_001077202
NM_001290467
NM_001290468
NM_015819 |
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| RefSeq (protein) | | |
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NP_001070670
NP_001277396
NP_001277397
NP_056634 |
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| Location (UCSC) | Chr X: 132.63 – 132.96 Mb | Chr X: 50.48 – 50.77 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Heparan sulfate 6-O-sulfotransferase 2 is a protein that in humans is encoded by the HS6ST2 gene. [5]
Function
Heparan sulfate proteoglycans are ubiquitous components of the cell surface, extracellular matrix, and basement membranes, and interact with various ligands to influence cell growth, differentiation, adhesion, and migration.
This gene encodes a member of the heparan sulfate (HS) sulfotransferase gene family, which catalyze the transfer of sulfate to HS. Different family members and isoforms are thought to synthesize heparan sulfates with tissue-specific structures and functions. Multiple transcript variants encoding different isoforms have been found for this gene.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000171004 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000062184 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Heparan sulfate 6-O-sulfotransferase 2". Retrieved 2016-07-11.
Further reading
- Habuchi H, Miyake G, Nogami K, Kuroiwa A, Matsuda Y, Kusche-Gullberg M, Habuchi O, Tanaka M, Kimata K (2003). "Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties". Biochem. J. 371 (Pt 1): 131–42. doi:10.1042/BJ20021259. PMC 1223259. PMID 12492399.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
