Protein-coding gene in the species Homo sapiens
| ING5 |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| Identifiers |
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| Aliases | ING5, p28inhibitor of growth family member 5 |
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| External IDs | OMIM: 608525; MGI: 1922816; HomoloGene: 90955; GeneCards: ING5; OMA:ING5 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 2 (human)[1] |
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| | Band | 2q37.3 | Start | 241,687,085 bp[1] |
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| End | 241,729,478 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 1 (mouse)[2] |
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| | Band | 1|1 D | Start | 93,731,687 bp[2] |
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| End | 93,749,823 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - sural nerve
- right uterine tube
- left ovary
- right hemisphere of cerebellum
- body of pancreas
- right lobe of thyroid gland
- left lobe of thyroid gland
- right ovary
- pituitary gland
- anterior pituitary
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| | Top expressed in | - primitive streak
- medullary collecting duct
- otic vesicle
- otolith organ
- hand
- utricle
- cumulus cell
- retinal pigment epithelium
- ciliary body
- epiblast
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| | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | - methylated histone binding
- protein binding
- metal ion binding
- chromatin binding
| | Cellular component | - MOZ/MORF histone acetyltransferase complex
- nucleus
- nucleoplasm
| | Biological process | - positive regulation of transcription, DNA-templated
- DNA replication
- negative regulation of growth
- regulation of transcription, DNA-templated
- histone acetylation
- histone H3 acetylation
- transcription, DNA-templated
- protein acetylation
- negative regulation of cell population proliferation
- positive regulation of apoptotic process
- regulation of signal transduction by p53 class mediator
- chromatin organization
- positive regulation of apoptotic signaling pathway
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | |
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NM_032329
NM_001330161
NM_001330162 |
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| RefSeq (protein) | |
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NP_001317090
NP_001317091
NP_115705 |
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| Location (UCSC) | Chr 2: 241.69 – 241.73 Mb | Chr 1: 93.73 – 93.75 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Inhibitor of growth protein 5 is a protein that in humans is encoded by the ING5 gene.[5][6]
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway.[6]
Interactions
ING5 has been shown to interact with EP300[5] and P53.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000168395 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026283 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC (May 2003). "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity". Cancer Res. 63 (10): 2373–8. PMID 12750254.
- ^ a b "Entrez Gene: ING5 inhibitor of growth family, member 5".
Further reading
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–865. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
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1wen: Solution structure of PHD domain in ING1-like protein BAC25079
2jmq:
