IRF9

Protein-coding gene in the species Homo sapiens
IRF9
Identifiers
AliasesIRF9, IRF-9, ISGF3, ISGF3G, p48, interferon regulatory factor 9
External IDsOMIM: 147574; MGI: 107587; HomoloGene: 4436; GeneCards: IRF9; OMA:IRF9 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for IRF9
Genomic location for IRF9
Band14q12Start24,161,265 bp[1]
End24,166,565 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for IRF9
Genomic location for IRF9
Band14 C3|14 28.19 cMStart55,841,028 bp[2]
End55,847,487 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • spleen

  • granulocyte

  • appendix

  • lymph node

  • blood

  • gallbladder

  • right uterine tube

  • anterior pituitary

  • bone marrow

  • bone marrow cells
Top expressed in
  • granulocyte

  • Ileal epithelium

  • spleen

  • lymph node

  • seminal vesicula

  • mesenteric lymph nodes

  • thymus

  • blood

  • left lung lobe

  • parotid gland
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • DNA binding
  • protein binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • RNA polymerase II cis-regulatory region sequence-specific DNA binding
Cellular component
  • nucleus
  • nucleoplasm
  • cytoplasm
  • cytosol
Biological process
  • cell surface receptor signaling pathway
  • regulation of transcription, DNA-templated
  • transcription by RNA polymerase II
  • defense response to virus
  • type I interferon signaling pathway
  • transcription, DNA-templated
  • interferon-gamma-mediated signaling pathway
  • regulation of transcription by RNA polymerase II
  • immune system process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10379

16391

Ensembl

ENSG00000213928
ENSG00000285048

ENSMUSG00000002325

UniProt

Q00978

Q61179

RefSeq (mRNA)

NM_006084
NM_001385400
NM_001385401
NM_001385402

NM_001159417
NM_001159418
NM_008394

RefSeq (protein)

NP_006075

NP_001152889
NP_001152890
NP_032420

Location (UCSC)Chr 14: 24.16 – 24.17 MbChr 14: 55.84 – 55.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interferon regulatory factor 9 is a protein that in humans is encoded by the IRF9 gene, previously known as ISGF3G.[5][6][7]

Interactions

IRF9 has been shown to interact with STAT2[8][9] and STAT1.[8]

References

  1. ^ a b c ENSG00000285048 GRCh38: Ensembl release 89: ENSG00000213928, ENSG00000285048 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002325 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Veals SA, Schindler C, Leonard D, Fu XY, Aebersold R, Darnell JE Jr, Levy DE (Aug 1992). "Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins". Mol Cell Biol. 12 (8): 3315–24. doi:10.1128/MCB.12.8.3315. PMC 364572. PMID 1630447.
  6. ^ McCusker D, Wilson M, Trowsdale J (Jun 1999). "Organization of the genes encoding the human proteasome activators PA28alpha and beta". Immunogenetics. 49 (5): 438–45. doi:10.1007/s002510050517. PMID 10199920. S2CID 40575791.
  7. ^ "Entrez Gene: ISGF3G interferon-stimulated transcription factor 3, gamma 48kDa".
  8. ^ a b Horvath, C M; Stark G R; Kerr I M; Darnell J E (Dec 1996). "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Mol. Cell. Biol. 16 (12). UNITED STATES: 6957–64. doi:10.1128/mcb.16.12.6957. ISSN 0270-7306. PMC 231699. PMID 8943351.
  9. ^ Martinez-Moczygemba, M; Gutch M J; French D L; Reich N C (Aug 1997). "Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3". J. Biol. Chem. 272 (32). UNITED STATES: 20070–6. doi:10.1074/jbc.272.32.20070. ISSN 0021-9258. PMID 9242679.

Further reading

  • Cebulla CM, Miller DM, Sedmak DD (2000). "Viral inhibition of interferon signal transduction". Intervirology. 42 (5–6): 325–30. doi:10.1159/000053968. PMID 10702714. S2CID 22135982.
  • Reich NC (2002). "Nuclear/cytoplasmic localization of IRFs in response to viral infection or interferon stimulation". J. Interferon Cytokine Res. 22 (1): 103–9. doi:10.1089/107999002753452719. PMID 11846981.
  • Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
  • David M, Romero G, Zhang ZY, et al. (1993). "In vitro activation of the transcription factor ISGF3 by interferon alpha involves a membrane-associated tyrosine phosphatase and tyrosine kinase". J. Biol. Chem. 268 (9): 6593–9. doi:10.1016/S0021-9258(18)53292-0. PMID 8454630.
  • Horvath CM, Stark GR, Kerr IM, Darnell JE (1997). "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex". Mol. Cell. Biol. 16 (12): 6957–64. doi:10.1128/mcb.16.12.6957. PMC 231699. PMID 8943351.
  • Martinez-Moczygemba M, Gutch MJ, French DL, Reich NC (1997). "Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3". J. Biol. Chem. 272 (32): 20070–6. doi:10.1074/jbc.272.32.20070. PMID 9242679.
  • Reddy PH, Stockburger E, Gillevet P, Tagle DA (1998). "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method". Genomics. 46 (2): 174–82. doi:10.1006/geno.1997.5044. PMID 9417904.
  • Lau JF, Parisien JP, Horvath CM (2000). "Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7278–83. Bibcode:2000PNAS...97.7278L. doi:10.1073/pnas.97.13.7278. PMC 16536. PMID 10860992.
  • Nehyba J, Hrdlicková R, Burnside J, Bose HR (2002). "A Novel Interferon Regulatory Factor (IRF), IRF-10, Has a Unique Role in Immune Defense and Is Induced by the v-Rel Oncoprotein". Mol. Cell. Biol. 22 (11): 3942–57. doi:10.1128/MCB.22.11.3942-3957.2002. PMC 133824. PMID 11997525.
  • Chawla-Sarkar M, Leaman DW, Jacobs BS, et al. (2002). "Resistance to interferons in melanoma cells does not correlate with the expression or activation of signal transducer and activator of transcription 1 (Stat1)". J. Interferon Cytokine Res. 22 (5): 603–13. doi:10.1089/10799900252982089. PMID 12060499.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lau JF, Nusinzon I, Burakov D, et al. (2003). "Role of Metazoan Mediator Proteins in Interferon-Responsive Transcription". Mol. Cell. Biol. 23 (2): 620–8. doi:10.1128/MCB.23.2.620-628.2003. PMC 151539. PMID 12509459.
  • Jikuya H, Takano J, Kikuno R, et al. (2003). "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones". DNA Res. 10 (1): 49–57. doi:10.1093/dnares/10.1.49. PMID 12693554.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Thompson HG, Harris JW, Lin L, Brody JP (2004). "Identification of the protein Zibra, its genomic organization, regulation, and expression in breast cancer cells". Exp. Cell Res. 295 (2): 448–59. doi:10.1016/j.yexcr.2004.01.019. PMID 15093743.
  • Sakamoto S, Potla R, Larner AC (2004). "Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes". J. Biol. Chem. 279 (39): 40362–7. doi:10.1074/jbc.M406400200. PMID 15194680.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

  • v
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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies
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