Indoprofen
Withdrawn NSAID drug
- M01AE10 (WHO)
- Withdrawn
- 2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)
phenyl]propanoic acid
- 31842-01-0
Y
- 3718
- DB08951 Y
- 3587 Y
- CPE46ZU14N
- D04530 Y
- CHEBI:76162 Y
- ChEMBL15870 Y
- DTXSID5045831
- Interactive image
- O=C(O)C(c1ccc(cc1)N3C(=O)c2ccccc2C3)C
- InChI=1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21)Y
- Key:RJMIEHBSYVWVIN-UHFFFAOYSA-NY
Indoprofen is a nonsteroidal anti-inflammatory drug (NSAID). It was withdrawn worldwide in the 1980s after postmarketing reports of severe gastrointestinal bleeding.[1]
A 2004 study using high-throughput screening found indoprofen to increase production of the survival of motor neuron protein, suggesting it may provide insight into treatments for spinal muscular atrophies.[1][2]
Synthesis
The isoindolone ring system forms the nucleus for this profen NSAID.
The nitro group in 2-(4-nitrophenyl)propionic acid (1) is reduced using iron and hydrochloric acid to give 2-(4-aminophenyl)propionic acid (2). Reaction with phthalic anhydride then gives the phthalimide (4). Treatment with zinc in acetic acid yields indoprofen after reduction of one of the amide groups.[3][4][5]
See also
References
- ^ a b Frazin N (March 9, 2005). "Pain Reliever May Provide Clues for Treating Spinal Muscular Atrophy". United States National Institute of Neurological Disorders and Stroke. Archived from the original on 2008-07-04. Retrieved 2007-10-06.
- ^ Lunn MR, Root DE, Martino AM, Flaherty SP, Kelley BP, Coovert DD, et al. (November 2004). "Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism". Chemistry & Biology. 11 (11): 1489–93. doi:10.1016/j.chembiol.2004.08.024. PMC 3160629. PMID 15555999.
- ^ US patent 4316850, Richard W. J. Carney and George de Stevens, "Tertiary aminoacids", issued 1982-02-23, assigned to Ciba Geigy Corp
- ^ Nannini G, Giraldi PN, Molgora G, Biasoli G, Spinelli F, Logemann W, et al. (August 1973). "New analgesic-anti-inflammatory drugs. 1-Oxo-2-substituted isoindoline derivatives". Arzneimittel-Forschung. 23 (8): 1090–100. doi:10.1002/chin.197344288. PMID 4801034.
- ^ "Indoprofen". Pharmaceutical Substances. Thieme. Retrieved 2024-07-11.
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pyrazolidines
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- Ampiroxicam
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derivatives (profens)
- Alminoprofen
- Benoxaprofen†
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- Ibuprofen#
- Ibuproxam
- Indoprofen†
- Ketoprofen
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acids (fenamates)
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Key: underline indicates initially developed first-in-class compound of specific group; #WHO-Essential Medicines; †withdrawn drugs; ‡veterinary use.
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