Jacob Hanna
Jacob H. Hanna | |
---|---|
يعقوب هاني حنا | |
![]() | |
Born | (1979-08-26) 26 August 1979 (age 44) Rameh, Israel |
Nationality | Palestinian |
Other names | Yaqub Hanna |
Citizenship | Israel |
Alma mater | Hebrew University of Jerusalem |
Known for | The world's first synthetic embryos |
Scientific career | |
Fields | Stem cell research |
Institutions | Weizmann Institute of Science |
Patrons | Rudolf Jaenisch |
Jacob H. Hanna (Arabic: Yaqub or Yaoub; born 26 August 1979)[1] is a Palestinian Arab-Israeli biologist[2] who is working as a professor in the Department of Molecular Genetics at the Weizmann Institute of Science in Rehovot, Israel.[3] An expert in embryonic stem cell research, he is most recognized for developing the first bona fide synthetic embryo models (also known as "complete embryo models") from stem cells in the petri dish in mice and humans.[4][5][6]
To achieve this, he first developed a technique for extended culturing mouse embryos outside the uterus (ex utero) in 2021 capturing development from before gastrulation until late organogenesis outside the uterus,[7][8] subsequently applying his technique for making the first synthetic complete embryo models of mice in 2022,[5][9][10] and then of human in 2023 that can be made solely from embryonic pluripotent stem cells and outside the womb.[11][12][13]
Hanna pioneered the extended static and dynamic post-implantation ex utero embryo growth platform [14] that was critical for enabling the synthetic complete embryo model establishment,[4] and also pioneered developing the technology to generate alternative naive-like and naive pluripotent states in humans, that correspond to more early stages in development and retain an enhanced potential to make essential extra-embryonic tissue (placenta and yolk-sac),[15][16] which proved essential for generating the first complete synthetic embryo models by his team [17][6][4]' and solely from such naive pluripotent cells.
Education
Hanna has a PhD in microbiology and immunology and an MD in clinical medicine from the Hebrew University of Jerusalem.[18] To train in stem cell research, he worked from 2007 to 2011 as a Helen Hay Whitney - Novartis postdoctoral fellow and a Genzyme postdoctoral fellow at the Whitehead Institute for Biomedical Research at MIT,[19] Cambridge, Massachusetts, under Rudolf Jaenisch.[2] In 2011, Hanna joined the Weizmann Institute of Science as an assistant professor in 2011, and has been there ever since and in 2018 Hanna received academic tenure and promotion at the Department of Molecular Genetics in the Weizmann Institute of Science, and in 2023 became a Full Professor of Stem Cell Biology and Synthetic Embryology.[20][21]
Hanna was listed in 2014 among top 40 under 40 leading international scientists by Cell journal[22] and elected to the European Molecular Biology Organization in 2018.[23] In 2021, he was announced as the top thinker of the year 2021 by Prospect magazine for his works on embryology.[24] His extended ex utero embryo culture was selected among Science Magazine Breakthrough of the year 2021,[25] and his mouse complete synthetic embryo models were selected by Nature magazine among seven technologies to watch in 2023. Human complete synthetic embryo model generated by Hanna was selected by the Time as invention breakthrough of the year 2023 [1], and the generation of synthetic embryo models of development through using stem cells was selected as the method of the year 2023 by Nature Methods.[26]
Early life
Hanna was born in Rameh, an Arab Palestinian village in the Galilee region of Israel to a Christian Palestinian family.[1] His father was a pediatrician and his mother was a high-school biology teacher. He studied medical science at the Hebrew University of Jerusalem, obtaining a B.Sc. degree summa cum laude in 2001, and then continued to do an M.D.-Ph.D. degree at the same institute. He indicated in his interviews that his decision to undertake a career in research was heavily influenced and inspired by the success of his uncle, Nabil Hanna, who invented the first FDA-approved antibody therapy in humans (Rituxan, a blockbuster anti-CD20 mAb drug for treatment of non-Hodgkin lymphoma) while serving as chief scientific office of IDEC Pharmaceuticals.[27] His Ph.D. research was supervised by Ofer Mandelboim and was on the roles of natural killer cells.[28] In 2007, the Hebrew University awarded him both Ph.D. in microbiology and immunology and M.D. in clinical medicine summa cum laude.[18]
Hanna decided not to go into practicing medicine but focus only on developing his research career in Academia. In 2007, he received the Helen Hay Whitney Foundation, and later a Genzyme-Whitehead Fellowship for outstanding postdoctoral fellows in 2009, by which he worked at the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts.[2] His research there till early 2011 under Rudolf Jaenisch helped him specialize in pluripotent stem cell research and induced pluripotent stem cell reprogramming.[2]
Research and discoveries
Induced pluripotent stem cell reprogramming
During his postdoctoral research at the Whitehead Institute, Hanna focused on studying embryonic stem cells (ESCs) and epigenetic reprogramming of somatic cells into ESC-like cells, called induced pluripotent stem cells (iPSCs). He developed transgenic mouse models to address problems in stem cell research. In 2007, he provided the first evidence that iPSCs could be used for a blood genetic disease, sickle cell anemia, by combined gene and cell therapy approach in mice.[29] His supervisor, Jaenisch was awarded the Masri Prize and the Wolf Prize in 2011 for this research innovation, as the award citation read: "For demonstration that iPS cells can be used to cure genetic disease in a mammal, thus establishing their therapeutic potential".[30]
Hanna made scientific contributions to understanding the iPSC phenomenon in its early days. He developed a novel inducible "reprogrammable mouse" transgenic models with drug controlled over expression of the Yamanaka reprogramming factors. This technique allowed him to create reprogrammed B lymphocytes carrying endogenous genetic rearrangements of the B-cell receptor (BCR) into iPSCs, thus providing definitive proof for the feasibility of reprogramming terminally differentiated cells to iPSCs that carried the original genetic rearrangement mark of the BCR.[31]
Epigenetic reprogramming and naive pluripotency
Initially, his independent group identified a number of key epigenetic regulators influencing iPSC derivation efficiency such as the role of H3K27 demethylase Utx in iPS formation,[32] and first demonstrated the deterministic reprogramming efficiencies (up to 100% within 8 days) via optimized depletion of Gatad2a/Mbd3 core member-axis of the NuRD co-repressor complex.[33][34] The latter work set the stage for others to show alternative methods to obtain deterministic reprogramming. For example, Thomas Graf group showed that transient activation of C/EBPα, previously highlighted by Hanna and Jaenisch as a booster for B cell reprogramming,[35] can yield up to 100% deterministic iPSC reprogramming from B cells within 8 days.[36] Hanna also identified SUMOylation of linker H1 histone[37] as a major determinant for transition between totipotency and naïve pluripotency states.
From 2013, Hanna worked as the Robertson Stem Cell Investigator of The New York Stem Cell Foundation.[38] His first major achievement under the NYSCF research was the demonstration that human naïve-like ES/iPS cell state tin NHSM naive-like conditions that he discovered (and later also in HENSM naive conditions), has additional unique functional properties compared to conventional primed iPS cells, which is the creation of sperm and egg stem cells from human skin cell derived naive-like iPSCs,[39] which has not been possible thus far with conventional human iPSCs. The experiment, done in collaboration with Azim Surani's team at the University of Cambridge, was published in the journal Cell in 2015.[40] David Cyranoski reported in Nature as "A feat achieved for the first time in humans".[41]
In 2014, Hanna criticized Jaenisch, his former postdoctoral mentor at the Whitehead Institute - MIT, accusing his team of publishing unreliable "false" negative experimental results on inability to generate any cross-species mouse-human chimerism in a paper published by Jaenisch on the pluripotency of human embryonic stem cells in the journal Cell Stem Cell.[42] Surprisingly, in 2016, Jaenisch and his team reported positive results on the same topic in the Proceedings of the National Academy of Sciences (PNAS) and reporting the ability to create chimeric embryo from a mixture of mouse and human cells.[43] In light of the latter, Hanna again raised the same critical comments in PubMed, suggesting retraction of a section of the previous 2014 Jaenisch paper in Cell Stem Cell that reported negative results, in contrast to the newly reported 2016 PNAS positive results by the same team led by Jaenisch.[42] Jaenisch published a correction in the same journal.[44] Later findings independently reported by Jun Wu group[45] and others[46] supported mouse-human cross-species chimerism with human pluripotent cells as originally reported by Hanna in 2013 [15] and expanded further by his group in 2021.[16] Human PSCs expanded in Hanna lab naive-like RSeT media were also independently shown to contribute to dopamine neurons in postnatal mouse-human cross species chimeras,[47] thus solidifying the earlier claims by Hanna and refuting those published by Jaenisch in 2014.
The Hanna team has also tackled pathways that resolve naive pluripotency programs and delineated a critical function for m6A RNA methylation in stem cell transitions in peri-implantation mouse development. Their study published in Science in 2015[48] provided the first evidence for the absolute essentiality of m6A mRNA epigenetic layer for mammalian embryo viability in vivo[48] and uncovered opposing tolerance of epigenetic repressor depletion in naive and primed cells from the same species,[48] that Hanna later used to optimize naive conditions in humans since only naive cells can tolerate genetic ablation or RNA and DNA methylation (deposited and maintained by METTL3 and DNMT1 enzymes, respectively).[16] Hanna used the latter property to screen for conditions that allow survival of human pluripotent cells without these enzymes and termed the conditions human enhanced naive stem cell media (HENSM).[16]
Hanna's lab also focused on deciphering the principles regulating naive pluripotency in different species and in 2013 his team was the first to derive human genetically unmodified MEK/ERK independent naïve-like pluripotent cells (termed NHSM conditions that were commercialized as RSeT by Stemcell Technologies).[15] Hanna next developed engineered systems to screen for enhanced NHSM conditions that maintain human pluripotent ES cells that can tolerate removal of RNA or DNA methylation enzymes (by ablating METTL3 or DNMT1 genes, respectively), and identified enhanced NHSM conditions (termed HENSM),[16] that can yield ESCs/iPSCs with more compelling characteristics of human pre-implantation blastocyst-morula stages.
From Naive Stem cells to synthetic complete embryo models developed ex utero - in mouse and human
Hanna is most recognized for developing a method, combining static and revamped "roller culture" conditions, for extended culturing of advanced mouse embryos outside the uterus (ex utero) in 2021 (from pre-gastrulation to late organogenesis for the first time),[49][14][50] subsequently allowing him to make the first synthetic complete and bona fide mouse embryo models derived only from naïve pluripotent stem cells in 2022.[51][52][4][53] In September 2023, Nature accepted Hanna's, previously preprinted article on bioRxiv on 14 June 2023,[17] on the generation of complete and structured day-14 synthetic human embryos derived from human naïve ES/iPS cells grown in his HENSM conditions.[16][6] Hanna's complete human stem cell-derived embryo model (SEM) can generate extra-embryonic trophoblast stem cells, mesoderm cells and primitive endoderm cells without genetic modification, transgene or transcription factor over-expression, and has structural and morphological uncanny similarity to day 14 human embryo inside the womb.[6][54][55][56] Conventional human (and mouse) primed ESCs/iPSCs fail to achieve this feat, highlighting the essentiality of capturing alternative naive pluripotent states in humans to be able to derive up to day 14 human SEMs.[6]
Prof Alfonso Martinez Arias, from the department of experimental and health sciences at Pompeu Fabra University, said it was "a most important piece of research". "The work has, for the first time, achieved a faithful construction of the complete structure [of a human embryo] from stem cells" in the lab, "thus opening the door for studies of the events that lead to the formation of the human body plan," Martinez-Arias said.[56] It was reported by Philip Ball that Dr. Bailey Weatherbee from the University of Cambridge who tried to generate human embryo models "is impressed by the embryo-like structures reported by Hanna's team, and agrees that their own don't have these structures."[57] Prof Robin Lovell Badge, who researches embryo development at the Francis Crick Institute, told the BBC that Hanna's human embryo models "do look pretty good" and "do look pretty normal". He also said "I think it's good, I thinks it's done very well, it's all making sense and I'm pretty impressed with it".[56]
Synthetic stem-cell-derived embryo model research related ethical discussions
In 2022, when Hanna published the first bona fide mouse synthetic embryo, he reported to the MIT Technology Review that he was already using the same method to make human embryo models (which indeed he was the first to report in 2023).[17][6][12] The funder company, NFX, stated that the aim is "renewing humanity—making all of us young and healthy."[58] When Hanna announced the creation of the first human synthetic embryo models in a preprinted manuscript on bioRxiv[17] and shortly after in Nature,[6] it was received as a "breakthrough"[59] and "groundbreaking advance" in science.[60] But Hanna's scientific feat raised further the discussions surrounding ethical and legal controversies.[61][62] The International Society for Stem Cell Research (ISSCR) has instituted guidelines for maintaining human embryos that are followed in most countries.[63] However, the guidelines or any other legislations do not cover synthetic embryo models,[64] as the embryo models are made from ordinary cells.[54] Hanna commented on Stat: "You don't ban nuclear physics because somebody can make a nuclear bomb."[65]
Rivron, Martinez Arias and others, writing on the ethical issues in Cell in 2023, expressed a possible need to open discussions about revising the definition of an embryo since certain embryo models can theoretically become functional embryos and produce babies.[64][66] Robin Lovell-Badge, at the Francis Crick Institute and member of the ISSCR guidelines preparation, also agreed that both natural and synthetic human embryo models should be regulated equally, saying, "These models do challenge the need to stick to the 14-day rule", referring the ISSCR's relaxation in 2021 the limit of growing human embryos up to 14 days.[63][62] The scientific and ethical complexity were remarked by J. Benjamin Hurlbut, bioethicist at the Arizona State University: "The big question is how the boundary between a tissue culture and a human organism is going to be drawn and on what criteria."[54] Pompeu Fabra University Professor Alfonso Martinez Arias, Ph.D., whose own lab is working on building human embryo models, noted that such conversations and debates are nothing new and should be welcomed.[67] The International Society for Stem Cell Research publicly announced support for the research[68] and highlighted to the public that such complete embryo models are only models of embryogenesis and should not be considered as embryos. British science writer, Philip Ball, alleviated concern related to this line of research by emphasizing that "None [of the embryo models] has the potential to grow into a human being, nor is there any reason why scientists would want them to."[69] Upon publication of Hanna's ground breaking paper on human complete stem cell-derived embryo models (termed SEMs) in Nature in 2023[6] Philip Ball tweeted "This is work at the absolute forefront of this extraordinary and exciting field".[70]
Awards and honors
- Named on the 2024 STATUS List by STAT news, a prestigious list with most influential individuals in healthcare, medicine, & life sciences [2][3]
- Human complete synthetic embryo model generated by Hanna was selected by the Time as invention breakthrough of the year 2023 [4],
- The generation of synthetic embryo models was selected as the method of the year 2023 by Nature Methods journal on behalf of Nature publishing group.[26]
- Mouse and human complete synthetic embryo models were selected by Nature magazine among seven technologies to watch in 2023.
- The IVI Foundation Award for Basic Research in Reproductive Medicine (2023)
- Manuscript describing mouse synthetic stem cell-derived embryo models among the 10 selected "Best of Cell 2022” publications by Cell journal editors (2023)[71]
- The 2022 paper on stem cell-derived (synthetic) embryogenesis listed among top scientific breakthroughs of the year 2022 by The Atlantic magazine[72] and The Week Magazine (2023)[73]
- A Paul Harris Fellow by the Rotary International Foundation in recognition for scientific achievements (2022)
- Selected as top thinker for the year 2021 by Prospect magazine, UK for his work on stem cells and synthetic embryology (2021)[24]
- Paper on ex utero embryogenesis listed among top scientific breakthroughs of the year by Science journal (2021)[25]
- Robert Edwards honorary lecture and lifetime achievement award by the COGI meeting in Berlin (2021)
- Research on ex utero embryogenesis was covered in a dedicated Nature Outlook article (2021)[74]
- Elected a member of the European Molecular Biology Organization (EMBO) (2018)[23]
- Research Professorship Award by the Israel Cancer Research Fund (ICRF) (2017)
- The Segal Family Award for Excellence in Stem Cell Biology, University of Michigan, USA (2016)
- The Kimmel Prize for outstanding scientist at the Weizmann Institute of Science (2015)
- Selected among "40 under 40" most innovative young scientists by Cell journal (2014)[22]
- Elected member of the Israeli Young Academy of Science (2014)[75]
- Robertson Innovator Award in Stem Cell Research by the New York Stem Cell Foundation (NYSCF) (2013)[76]
- Krill Prize for outstanding early career scientists by the Wolf Foundation (2013)[77]
- The Rappaport Prize for a Young Researcher in Biomedicine by the Bruce and Ruth Rappaport Foundation (2013)[78]
- Elected member of the European Molecular Biology Organization Young Investigator Program (EMBO-YIP) (2012)[5]
- Inaugural Award for Excellence in Biomedical Research by the Palestinian Society for Biomedical Research (2011)
- Alon Foundation Scholar for distinguished junior faculty in Israeli academia (2011)
- The Clore Prize for an outstanding new scientist at the Weizmann Institute of Science (2011)
- TR35 Young Innovator Award for international innovators under the age of 35 by MIT Technology Review magazine (2010)[79]
- Genzyme Postdoctoral Prize and Fellowship for Outstanding Postdoc at the Whitehead Institute (2010)[20]
- Novartis Postdoctoral Fellowship by the Helen Hay Whitney Foundation – Novartis Fellow (2007)[20]
- Hebrew University Medical School Excellence Award for graduating M.D.-Ph.D. students, Hebrew University of Jerusalem (2007)
- Max Schlomiuk Award for Ph.D. students graduating with distinction (summa cum laude), Hebrew University of Jerusalem (2007)
- Gertrude Kohn Award for outstanding scientific work in human genetics, Hebrew University of Jerusalem (2005)
- Foulkes Foundation Award and Scholarship for M.D.- Ph.D. students (2004)
- Wolf Foundation Award and Fellowship for Outstanding Ph.D. students (2003)
References
- ^ a b "Yakoub Hanna". myheritage.com. Retrieved 2023-08-24.
- ^ a b c d Gewin, Virginia (2010). "Turning point: Jacob Hanna". Nature. 468 (7321): 337. doi:10.1038/nj7321-337a. ISSN 0028-0836.
- ^ Siegel-Itzkovich, Judy (2022-08-02). "Israeli scientists make model synthetic mouse embryo with stem cells". The Jerusalem Post. Retrieved 2023-08-24.
- ^ a b c d Tarazi, Shadi; Aguilera-Castrejon, Alejandro; Joubran, Carine; Ghanem, Nadir; Ashouokhi, Shahd; Roncato, Francesco; Wildschutz, Emilie; Haddad, Montaser; Oldak, Bernardo; Gomez-Cesar, Elidet; Livnat, Nir; Viukov, Sergey; Lokshtanov, Dmitry; Naveh-Tassa, Segev; Rose, Max (September 2022). "Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs". Cell. 185 (18): 3290–3306.e25. doi:10.1016/j.cell.2022.07.028. ISSN 0092-8674. PMC 9439721. PMID 35988542.
- ^ a b Sample, Ian (2022-08-03). "Scientists create world's first 'synthetic embryos'". The Guardian. ISSN 0261-3077. Retrieved 2023-08-24.
- ^ a b c d e f g h Oldak, Bernardo; Wildschutz, Emilie; Bondarenko, Vladyslav; Comar, Mehmet-Yunus; Zhao, Cheng; Aguilera-Castrejon, Alejandro; Tarazi, Shadi; Viukov, Sergey; Pham, Thi Xuan Ai; Ashouokhi, Shahd; Lokshtanov, Dmitry; Roncato, Francesco; Ariel, Eitan; Rose, Max; Livnat, Nir (2023-09-06). "Complete human day 14 post-implantation embryo models from naïve ES cells". Nature. 622 (7983): 562–573. Bibcode:2023Natur.622..562O. doi:10.1038/s41586-023-06604-5. ISSN 1476-4687. PMC 10584686. PMID 37673118. S2CID 261581458.
- ^ "Scientists grow mice embryos to half-term in glass artificial uterus". The Week. 18 March 2021. Retrieved 2023-08-28.
- ^ Gina, Kolata (2021-03-17). "Scientists Grow Mouse Embryos in a Mechanical Womb". The New York Times.
- ^ "Synthetic mouse embryos with brains and beating hearts grown using only skin cells". The Independent. 2022-08-02. Retrieved 2023-08-28.
- ^ "Mouse Embryo: No Sperm, Egg, or Uterus Required". The Scientist Magazine®. Retrieved 2023-08-28.
- ^ Zimmer, Carl (2023-06-24). "Scientists Debut Lab Models of Human Embryos". The New York Times. ISSN 0362-4331. Retrieved 2023-08-24.
- ^ a b Ansede, Manuel (June 15, 2023). "New 14-day embryo model sheds light on the biggest enigma of human development". EL PAIS.
- ^ "Scientists create world's first 'synthetic' embryos". BBC Reel. Retrieved 2023-09-19.
- ^ a b Aguilera-Castrejon, Alejandro; Oldak, Bernardo; Shani, Tom; Ghanem, Nadir; Itzkovich, Chen; Slomovich, Sharon; Tarazi, Shadi; Bayerl, Jonathan; Chugaeva, Valeriya; Ayyash, Muneef; Ashouokhi, Shahd; Sheban, Daoud; Livnat, Nir; Lasman, Lior; Viukov, Sergey (May 2021). "Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis". Nature. 593 (7857): 119–124. Bibcode:2021Natur.593..119A. doi:10.1038/s41586-021-03416-3. ISSN 1476-4687. PMID 33731940. S2CID 232296340.
- ^ a b c Gafni, Ohad; Weinberger, Leehee; Mansour, Abed AlFatah; Manor, Yair S.; Chomsky, Elad; Ben-Yosef, Dalit; Kalma, Yael; Viukov, Sergey; Maza, Itay; Zviran, Asaf; Rais, Yoach; Shipony, Zohar; Mukamel, Zohar; Krupalnik, Vladislav; Zerbib, Mirie (2013-12-12). "Derivation of novel human ground state naive pluripotent stem cells". Nature. 504 (7479): 282–286. Bibcode:2013Natur.504..282G. doi:10.1038/nature12745. ISSN 0028-0836. PMID 24172903. S2CID 4462419.
- ^ a b c d e f Bayerl, Jonathan; Ayyash, Muneef; Shani, Tom; Manor, Yair Shlomo; Gafni, Ohad; Massarwa, Rada; Kalma, Yael; Aguilera-Castrejon, Alejandro; Zerbib, Mirie; Amir, Hadar; Sheban, Daoud; Geula, Shay; Mor, Nofar; Weinberger, Leehee; Naveh Tassa, Segev (September 2021). "Principles of signaling pathway modulation for enhancing human naive pluripotency induction". Cell Stem Cell. 28 (9): 1549–1565.e12. doi:10.1016/j.stem.2021.04.001. PMC 8423434. PMID 33915080.
- ^ a b c d Oldak, Bernardo; Wildschutz, Emilie; Bondarenko, Vladyslav; Aguilera-Castrejon, Alejandro; Zhao, Cheng; Tarazi, Shadi; Comar, Mehmet-Yunus; Ashouokhi, Shahd; Lokshtanov, Dmitry (2023-06-15). Transgene-Free Ex Utero Derivation of A Human Post-Implantation Embryo Model Solely from Genetically Unmodified Naïve PSCs (Report). Developmental Biology. doi:10.1101/2023.06.14.544922.
- ^ a b "האקדמיה הלאומית הישראלית למדעים The Israel Academy of Sciences and Humanities - Jacob Hanna". The Israel Academy of Sciences and Humanities. Retrieved 2023-08-24.
- ^ Hanna, Jacob; Saha, Krishanu; Pando, Bernardo; van Zon, Jeroen; Lengner, Christopher J.; Creyghton, Menno P.; van Oudenaarden, Alexander; Jaenisch, Rudolf (December 2009). "Direct cell reprogramming is a stochastic process amenable to acceleration". Nature. 462 (7273): 595–601. Bibcode:2009Natur.462..595H. doi:10.1038/nature08592. hdl:1721.1/58480. ISSN 1476-4687. PMC 2789972. PMID 19898493.
- ^ a b c "Jacob H Hanna". Dimensions.ai. Retrieved 2023-08-31.
- ^ "Jacob (Yaqub) Hanna | Department of Molecular Genetics". www.weizmann.ac.il. Retrieved 2023-09-09.
- ^ a b Marcus, Emilie (2014-12-18). "Guidance for Early-Career Scientists". Voices. 159 (7): 1486–1487 – via Cell journal.
- ^ a b "Find people in the EMBO Communities". people.embo.org. Retrieved 2023-08-28.
- ^ a b Team, Prospect. "The world's top 50 thinkers 2021". www.prospectmagazine.co.uk. Retrieved 2023-08-28.
- ^ a b "Science's 2021 Breakthroughs of the Year". Science. 2021-12-16.
- ^ a b "Method of the Year 2023: methods for modeling development". Nature Methods. 20 (12): 1831–1832. December 2023. doi:10.1038/s41592-023-02134-0. ISSN 1548-7105. PMID 38057526.
- ^ "A winning pair | Two Weizmann scientists chosen by Cell magazine | WeizmannCompass". www.weizmann.ac.il. 2017-06-25. Retrieved 2023-08-29.
- ^ Hanna, Jacob; Mandelboim, Ofer (2007). "When killers become helpers". Trends in Immunology. 28 (5): 201–206. doi:10.1016/j.it.2007.03.005. ISSN 1471-4906. PMID 17403615.
- ^ Hanna, Jacob; Wernig, Marius; Markoulaki, Styliani; Sun, Chiao-Wang; Meissner, Alexander; Cassady, John P.; Beard, Caroline; Brambrink, Tobias; Wu, Li-Chen; Townes, Tim M.; Jaenisch, Rudolf (2007-12-21). "Treatment of Sickle Cell Anemia Mouse Model with iPS Cells Generated from Autologous Skin". Science. 318 (5858): 1920–1923. Bibcode:2007Sci...318.1920H. doi:10.1126/science.1152092. ISSN 0036-8075. PMID 18063756. S2CID 657569.
- ^ "Rudolf Jaenisch". Wolf Foundation. 2018-12-11. Retrieved 2023-08-29.
- ^ Hanna, Jacob; Markoulaki, Styliani; Schorderet, Patrick; Carey, Bryce W.; Beard, Caroline; Wernig, Marius; Creyghton, Menno P.; Steine, Eveline J.; Cassady, John P.; Foreman, Ruth; Lengner, Christopher J.; Dausman, Jessica A.; Jaenisch, Rudolf (April 2008). "Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency". Cell. 133 (2): 250–264. doi:10.1016/j.cell.2008.03.028. ISSN 0092-8674. PMC 2615249. PMID 18423197.
- ^ Mansour, Abed AlFatah; Gafni, Ohad; Weinberger, Leehee; Zviran, Asaf; Ayyash, Muneef; Rais, Yoach; Krupalnik, Vladislav; Zerbib, Mirie; Amann-Zalcenstein, Daniela; Maza, Itay; Geula, Shay; Viukov, Sergey; Holtzman, Liad; Pribluda, Ariel; Canaani, Eli (August 2012). "The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming". Nature. 488 (7411): 409–413. Bibcode:2012Natur.488..409M. doi:10.1038/nature11272. ISSN 1476-4687. PMID 22801502. S2CID 4415587.
- ^ Mor, Nofar; Rais, Yoach; Sheban, Daoud; Peles, Shani; Aguilera-Castrejon, Alejandro; Zviran, Asaf; Elinger, Dalia; Viukov, Sergey; Geula, Shay; Krupalnik, Vladislav; Zerbib, Mirie; Chomsky, Elad; Lasman, Lior; Shani, Tom; Bayerl, Jonathan (September 2018). "Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency". Cell Stem Cell. 23 (3): 412–425.e10. doi:10.1016/j.stem.2018.07.004. PMC 7116536. PMID 30122475.
- ^ Zviran, Asaf; Mor, Nofar; Rais, Yoach; Gingold, Hila; Peles, Shani; Chomsky, Elad; Viukov, Sergey; Buenrostro, Jason D.; Scognamiglio, Roberta; Weinberger, Leehee; Manor, Yair S.; Krupalnik, Vladislav; Zerbib, Mirie; Hezroni, Hadas; Jaitin, Diego Adhemar (February 2019). "Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules". Cell Stem Cell. 24 (2): 328–341.e9. doi:10.1016/j.stem.2018.11.014. PMC 7116520. PMID 30554962.
- ^ Hanna, Jacob; Markoulaki, Styliani; Schorderet, Patrick; Carey, Bryce W.; Beard, Caroline; Wernig, Marius; Creyghton, Menno P.; Steine, Eveline J.; Cassady, John P.; Foreman, Ruth; Lengner, Christopher J.; Dausman, Jessica A.; Jaenisch, Rudolf (April 2008). "Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency". Cell. 133 (2): 250–264. doi:10.1016/j.cell.2008.03.028. PMC 2615249. PMID 18423197.
- ^ Di Stefano, Bruno; Sardina, Jose Luis; van Oevelen, Chris; Collombet, Samuel; Kallin, Eric M.; Vicent, Guillermo P.; Lu, Jun; Thieffry, Denis; Beato, Miguel; Graf, Thomas (2014-02-13). "C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells". Nature. 506 (7487): 235–239. Bibcode:2014Natur.506..235D. doi:10.1038/nature12885. hdl:10803/283484. ISSN 0028-0836. PMID 24336202. S2CID 4468460.
- ^ Sheban, Daoud; Shani, Tom; Maor, Roey; Aguilera-Castrejon, Alejandro; Mor, Nofar; Oldak, Bernardo; Shmueli, Merav D.; Eisenberg-Lerner, Avital; Bayerl, Jonathan; Hebert, Jakob; Viukov, Sergey; Chen, Guoyun; Kacen, Assaf; Krupalnik, Vladislav; Chugaeva, Valeriya (January 2022). "SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity". Molecular Cell. 82 (1): 106–122.e9. doi:10.1016/j.molcel.2021.11.011. PMID 34875212. S2CID 244931130.
- ^ "Jacob Hanna, MD, PhD". New York Stem Cell Foundation. Retrieved 2023-08-25.
- ^ "In a First, Weizmann Institute and Cambridge University Scientists Create Human Primordial Germ Cells". www.newswise.com. Retrieved 2023-08-25.
- ^ Irie, Naoko; Weinberger, Leehee; Tang, Walfred W. C.; Kobayashi, Toshihiro; Viukov, Sergey; Manor, Yair S.; Dietmann, Sabine; Hanna, Jacob H.; Surani, M. Azim (2015-01-15). "SOX17 is a critical specifier of human primordial germ cell fate". Cell. 160 (1–2): 253–268. doi:10.1016/j.cell.2014.12.013. ISSN 1097-4172. PMC 4310934. PMID 25543152.
- ^ Cyranoski, David (2014-12-24). "Rudimentary egg and sperm cells made from stem cells". Nature. doi:10.1038/nature.2014.16636. ISSN 0028-0836. S2CID 87957769.
- ^ a b Theunissen, Thorold W.; Powell, Benjamin E.; Wang, Haoyi; Mitalipova, Maya; Faddah, Dina A.; Reddy, Jessica; Fan, Zi Peng; Maetzel, Dorothea; et al. (2014-10-02). "Systematic identification of culture conditions for induction and maintenance of naive human pluripotency". Cell Stem Cell. 15 (4): 471–487. doi:10.1016/j.stem.2014.07.002. ISSN 1875-9777. PMC 4184977. PMID 25090446.
- ^ Cohen, Malkiel A.; Wert, Katherine J.; Goldmann, Johanna; Markoulaki, Styliani; Buganim, Yosef; Fu, Dongdong; Jaenisch, Rudolf (2016-02-09). "Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos". Proceedings of the National Academy of Sciences of the United States of America. 113 (6): 1570–1575. Bibcode:2016PNAS..113.1570C. doi:10.1073/pnas.1525518113. ISSN 1091-6490. PMC 4760776. PMID 26811475.
- ^ Theunissen, Thorold W.; Powell, Benjamin E.; Wang, Haoyi; Mitalipova, Maya; Faddah, Dina A.; Reddy, Jessica; Fan, Zi Peng; Maetzel, Dorothea; et al. (2014-10-02). "Erratum: Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency". Cell Stem Cell. 15 (4): 523. doi:10.1016/j.stem.2014.08.002. ISSN 1875-9777. PMC 5628950. PMID 28903029.
- ^ Zheng, Canbin; Hu, Yingying; Sakurai, Masahiro; Pinzon-Arteaga, Carlos A.; Li, Jie; Wei, Yulei; Okamura, Daiji; Ravaux, Benjamin; Barlow, Haley Rose; Yu, Leqian; Sun, Hai-Xi; Chen, Elizabeth H.; Gu, Ying; Wu, Jun (April 2021). "Cell competition constitutes a barrier for interspecies chimerism". Nature. 592 (7853): 272–276. Bibcode:2021Natur.592..272Z. doi:10.1038/s41586-021-03273-0. ISSN 1476-4687. PMC 11163815. PMID 33508854. S2CID 231761771.
- ^ Hu, Zhixing; Li, Hanqin; Jiang, Houbo; Ren, Yong; Yu, Xinyang; Qiu, Jingxin; Stablewski, Aimee B.; Zhang, Boyang; Buck, Michael J.; Feng, Jian (2020-05-15). "Transient inhibition of mTOR in human pluripotent stem cells enables robust formation of mouse-human chimeric embryos". Science Advances. 6 (20): eaaz0298. Bibcode:2020SciA....6..298H. doi:10.1126/sciadv.aaz0298. ISSN 2375-2548. PMC 7220352. PMID 32426495.
- ^ Wang, Hu; Yin, Xiling; Xu, Jinchong; Chen, Li; Karuppagounder, Senthilkumar S.; Xu, Enquan; Mao, Xiaobo; Dawson, Valina L.; Dawson, Ted M. (January 2024). "Interspecies chimerism with human embryonic stem cells generates functional human dopamine neurons at low efficiency". Stem Cell Reports. 19 (1): 54–67. doi:10.1016/j.stemcr.2023.11.009. PMC 10828682. PMID 38134925.
- ^ a b c Geula, Shay; Moshitch-Moshkovitz, Sharon; Dominissini, Dan; Mansour, Abed AlFatah; Kol, Nitzan; Salmon-Divon, Mali; Hershkovitz, Vera; Peer, Eyal; Mor, Nofar; Manor, Yair S.; Ben-Haim, Moshe Shay; Eyal, Eran; Yunger, Sharon; Pinto, Yishay; Jaitin, Diego Adhemar (2015-02-27). "m 6 A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation". Science. 347 (6225): 1002–1006. Bibcode:2015Sci...347.1002G. doi:10.1126/science.1261417. ISSN 0036-8075. PMID 25569111. S2CID 206562941.
- ^ Vogel, Gretchen (2021-03-17). "No uterus, no problem: Mouse embryos grown in bottles form organs and limbs". Science. doi:10.1126/science.abi5734. ISSN 0036-8075. S2CID 233707850.
- ^ "A mouse embryo has been grown in an artificial womb—humans could be next". MIT Technology Review. Retrieved 2023-08-28.
- ^ Johnson, Carolyn (August 1, 2022). "Scientists create synthetic mouse embryos, a potential key to healing humans". The Washington Post.
- ^ Leslie, Mitch (2022-08-02). "With innovative bioreactor as womb, mouse stem cells transform into organ-filled embryos". Science.
- ^ Molteni, Megan (2022-08-01). "Synthetic mouse embryos created from stem cells — without sperm, eggs, or a uterus". STAT. Retrieved 2023-08-28.
- ^ a b c Leslie, Mitch (2023-06-23). "Human stem cells turned into detailed lab replicas of embryos". Science. 380 (6651): 1206–1207. Bibcode:2023Sci...380.1206L. doi:10.1126/science.adj3373. ISSN 1095-9203. PMID 37347850. S2CID 259223207.
- ^ "Israeli Scientists Create 'Incredibly Human-like' Artificial Embryo Model". Haaretz. Retrieved 2023-09-08.
- ^ a b c "Scientists grow whole model of human embryo, without sperm or egg". BBC News. 2023-09-06. Retrieved 2023-09-08.
- ^ Ball, Philip (2023-07-01). "Are human embryo models a cause for hope or alarm?". The Observer. ISSN 0029-7712. Retrieved 2023-09-08.
- ^ Regalado, Antonio (2022-08-04). "This startup wants to copy you into an embryo for organ harvesting". MIT Technology Review. Retrieved 2023-09-01.
- ^ Ghert-Zand, Renee (15 June 2023). "In breakthrough, Israeli scientists say they synthesized human embryos from stem cells". Times of Israel. Retrieved 2023-09-01.
- ^ Devlin, Hannah (2023-06-14). "Synthetic human embryos created in groundbreaking advance". The Guardian. ISSN 0261-3077. Retrieved 2023-09-01.
- ^ Ball, Philip (2023). "Most advanced synthetic human embryos yet spark controversy". Nature. 618 (7966): 653–654. Bibcode:2023Natur.618..653B. doi:10.1038/d41586-023-01992-0. ISSN 1476-4687. PMID 37328563. S2CID 259183998.
- ^ a b Devlin, Hannah (2023-06-14). "Advances in synthetic embryos leave legislators needing to catch up". The Guardian. ISSN 0261-3077. Retrieved 2023-09-01.
- ^ a b Lovell-Badge, Robin; Anthony, Eric; Barker, Roger A.; Bubela, Tania; Brivanlou, Ali H.; Carpenter, Melissa; Charo, R. Alta; Clark, Amander; et al. (2021-06-08). "ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update". Stem Cell Reports. 16 (6): 1398–1408. doi:10.1016/j.stemcr.2021.05.012. ISSN 2213-6711. PMC 8190668. PMID 34048692.
- ^ a b Ball, Philip (2023-06-13). "'Embryo Models' Challenge Legal, Ethical and Biological Concepts". Quanta Magazine.
- ^ Wosen, Jonathan (2023-02-13). "'It is a balance': Scientists grapple with ethics of cutting-edge stem cell research". STAT. Retrieved 2023-09-02.
- ^ Rivron, Nicolas C.; Martinez Arias, Alfonso; Pera, Martin F.; Moris, Naomi; M'hamdi, Hafez Ismaili (2023-08-17). "An ethical framework for human embryology with embryo models". Cell. 186 (17): 3548–3557. doi:10.1016/j.cell.2023.07.028. hdl:10230/58014. ISSN 1097-4172. PMID 37595564. S2CID 260960847.
- ^ Helen, Floresh (Sep 8, 2023). "Human embryo models offer window into early development".
- ^ "The ISSCR Statement on New Research with Embryo Models". International Society for Stem Cell Research. 2023-06-26. Retrieved 2023-09-02.
- ^ Ball, Philip (2023-07-01). "Are human embryo models a cause for hope or alarm?". The Observer. ISSN 0029-7712. Retrieved 2023-09-01.
- ^ "@philipcball". X (formerly Twitter). Retrieved 2023-09-08.
- ^ "Best of Cell 2022". info.cell.com. Retrieved 2023-08-28.
- ^ Thompson, Derek (2022-12-08). "Breakthroughs of the Year". The Atlantic. Retrieved 2023-08-28.
- ^ "18 recent scientific breakthroughs". The Week. Retrieved 2023-08-28.
- ^ Svoboda, Elizabeth (2021-09-29). "The next frontier for human embryo research". Nature. 597 (7878): S15–S17. Bibcode:2021Natur.597S..15S. doi:10.1038/d41586-021-02625-0. S2CID 238228629.
- ^ "7 researchers under 45 named to Israel Young Academy of Sciences and the Arts". The Jerusalem Post | JPost.com. 8 June 2014. Retrieved 2023-09-02.
- ^ "Jacob Hanna, MD, PhD". New York Stem Cell Foundation. Retrieved 2023-08-28.
- ^ "Jacob Hanna". Wolf Foundation. 2020-01-08. Retrieved 2023-08-28.
- ^ "about". www.rappaport-prize.org.il. Retrieved 2023-08-28.
- ^ "Jacob Hanna". MIT Technology Review. Retrieved 2023-08-28.