Kaempferide
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IUPAC name 3,5,7-Trihydroxy-4′-methoxyflavone | |
Systematic IUPAC name 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one | |
Other names Kaempferid 4′-Methylkaempferol Kaempferol 4′-methyl ether 4′-O-Methylkaempferol | |
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ECHA InfoCard | 100.007.036 ![]() |
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Properties | |
Chemical formula | C16H12O6 |
Molar mass | 300.26 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ![]() ![]() ![]() Infobox references |
Chemical compound
Kaempferide is an O-methylated flavonol, a type of chemical compound. It can be found in Kaempferia galanga (aromatic ginger). It has been noted to inhibit pancreatic cancer growth by blockading an EGFR-related pathway.[1]
Metabolism
The enzyme kaempferol 4'-O-methyltransferase uses S-adenosyl-L-methionine and kaempferol to produce S-adenosyl-L-homocysteine and kaempferide.
Glycosides
Icariin is the tert-amyl alcohol derivative of kaempferide 3,7-O-diglycoside.
References
- ^ Lee, Jungwhoi; Kim, Jae Hoon (2016). "Kaempferol Inhibits Pancreatic Cancer Cell Growth and Migration through the Blockade of EGFR-Related Pathway In Vitro". PLOS ONE. 11 (5): e0155264. Bibcode:2016PLoSO..1155264L. doi:10.1371/journal.pone.0155264. PMC 4866780. PMID 27175782.
External links
- Kaempferide at the HMDB
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Flavonols and their conjugates
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