Protein-coding gene in the species Homo sapiens
LILRB5 |
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Identifiers |
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Aliases | LILRB5, CD85C, LIR-8, LIR8, leukocyte immunoglobulin like receptor B5 |
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External IDs | OMIM: 604814; HomoloGene: 134027; GeneCards: LILRB5; OMA:LILRB5 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 19 (human)[1] |
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| Band | 19q13.42 | Start | 54,249,421 bp[1] |
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End | 54,257,301 bp[1] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - spleen
- thymus
- subcutaneous adipose tissue
- right adrenal cortex
- left adrenal gland
- left adrenal cortex
- placenta
- duodenum
- right coronary artery
- gastric mucosa
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| | More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - transmembrane signaling receptor activity
| Cellular component | - integral component of membrane
- membrane
| Biological process | - defense response
- cell surface receptor signaling pathway
- adaptive immune response
- immune system process
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | ENSG00000274311 ENSG00000278437 ENSG00000273991 ENSG00000277414 ENSG00000105609
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n/a |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001081442 NM_001081443 NM_001304457 NM_006840 |
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RefSeq (protein) | |
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NP_001074911 NP_001074912 NP_001291386 NP_006831 |
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Location (UCSC) | Chr 19: 54.25 – 54.26 Mb | n/a |
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PubMed search | [2] | n/a |
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Wikidata |
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Leukocyte immunoglobulin-like receptor subfamily B member 5 is a protein that in humans is encoded by the LILRB5 gene.[3][4]
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene.[4]
References
- ^ a b c ENSG00000278437, ENSG00000273991, ENSG00000277414, ENSG00000105609 GRCh38: Ensembl release 89: ENSG00000274311, ENSG00000278437, ENSG00000273991, ENSG00000277414, ENSG00000105609 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (Apr 1998). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". J Immunol. 159 (11): 5192–6. doi:10.4049/jimmunol.159.11.5192. PMID 9548455.
- ^ a b "Entrez Gene: LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5".
Further reading
- Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.