Lactate dehydrogenase b

LDHB
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1I0Z, 1T2F

Identifiers
AliasesLDHB, HEL-S-281, LDH-B, LDH-H, LDHBD, TRG-5, lactate dehydrogenase B
External IDsOMIM: 150100; MGI: 96763; HomoloGene: 55647; GeneCards: LDHB; OMA:LDHB - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for LDHB
Genomic location for LDHB
Band12p12.1Start21,635,342 bp[1]
End21,757,857 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for LDHB
Genomic location for LDHB
Band6 G2|6 74.17 cMStart142,435,975 bp[2]
End142,453,683 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • renal medulla

  • right ventricle

  • external globus pallidus

  • endothelial cell

  • lateral nuclear group of thalamus

  • myocardium of left ventricle

  • Pars compacta

  • pars reticulata

  • kidney tubule

  • middle temporal gyrus
Top expressed in
  • primary oocyte

  • secondary oocyte

  • zygote

  • right kidney

  • right ventricle

  • primary visual cortex

  • superior frontal gyrus

  • vestibular membrane of cochlear duct

  • anterior horn of spinal cord

  • proximal tubule
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
  • oxidoreductase activity
  • lactate dehydrogenase activity
  • protein binding
  • kinase binding
  • NAD binding
  • catalytic activity
  • L-lactate dehydrogenase activity
  • identical protein binding
Cellular component
  • extracellular exosome
  • membrane raft
  • membrane
  • myelin sheath
  • mitochondrion
  • cytoplasm
  • cytosol
Biological process
  • NAD metabolic process
  • lactate metabolic process
  • carboxylic acid metabolic process
  • pyruvate metabolic process
  • carbohydrate metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3945

16832

Ensembl

ENSG00000111716

ENSMUSG00000030246

UniProt

P07195

P16125

RefSeq (mRNA)

NM_001174097
NM_002300
NM_001315537

NM_008492
NM_001302765
NM_001316322

RefSeq (protein)

NP_001167568
NP_001302466
NP_002291

NP_001289694
NP_001303251
NP_032518

Location (UCSC)Chr 12: 21.64 – 21.76 MbChr 6: 142.44 – 142.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lactate dehydrogenase B is a protein that in humans is encoded by the LDHB gene. [5]

Function

This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111716 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030246 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Lactate dehydrogenase B". Retrieved 2017-10-01.

Further reading

  • Philibert RA, Nelson JJ, Sandhu HK, Crowe RR, Coryell WH (2003). "Association of an exonic LDHA polymorphism with altered respiratory response in probands at high risk for panic disorder". Am. J. Med. Genet. B Neuropsychiatr. Genet. 117B (1): 11–7. doi:10.1002/ajmg.b.10015. PMID 12555229. S2CID 25994539.
  • Mazzotta S, Guerranti R, Gozzetti A, Bucalossi A, Bocchia M, Sammassimo S, Petralia S, Ogueli GI, Lauria F (2006). "Increased serum lactate dehydrogenase isoenzymes in Ph-negative chronic myeloproliferative diseases: a metabolic adaptation?". Hematology. 11 (4): 239–44. doi:10.1080/10245330600774835. PMID 17178662. S2CID 36110689.
  • de Haas T, Hasselt N, Troost D, Caron H, Popovic M, Zadravec-Zaletel L, Grajkowska W, Perek M, Osterheld MC, Ellison D, Baas F, Versteeg R, Kool M (2008). "Molecular risk stratification of medulloblastoma patients based on immunohistochemical analysis of MYC, LDHB, and CCNB1 expression". Clin. Cancer Res. 14 (13): 4154–60. doi:10.1158/1078-0432.CCR-07-4159. PMID 18593994.
  • Whyte MP, Kempa LG, McAlister WH, Zhang F, Mumm S, Wenkert D (2010). "Elevated serum lactate dehydrogenase isoenzymes and aspartate transaminase distinguish Albers-Schönberg disease (Chloride Channel 7 Deficiency Osteopetrosis) among the sclerosing bone disorders". J. Bone Miner. Res. 25 (11): 2515–26. doi:10.1002/jbmr.130. PMID 20499337. S2CID 22022750.
  • Egberts F, Momkvist A, Egberts JH, Kaehler KC, Hauschild A (2010). "Serum S100B and LDH are not useful in predicting the sentinel node status in melanoma patients". Anticancer Res. 30 (5): 1799–805. PMID 20592382.
  • Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLOS ONE. 5 (9): e12862. Bibcode:2010PLoSO...512862H. doi:10.1371/journal.pone.0012862. PMC 2943476. PMID 20877624.
  • Swiderek K, Paneth P (2011). "Differences and similarities in binding of pyruvate and L-lactate in the active site of M4 and H4 isoforms of human lactate dehydrogenase". Arch. Biochem. Biophys. 505 (1): 33–41. doi:10.1016/j.abb.2010.10.010. PMID 20951115.
  • Zha X, Wang F, Wang Y, He S, Jing Y, Wu X, Zhang H (2011). "Lactate dehydrogenase B is critical for hyperactive mTOR-mediated tumorigenesis". Cancer Res. 71 (1): 13–8. doi:10.1158/0008-5472.CAN-10-1668. PMID 21199794.
  • Kim JH, Kim EL, Lee YK, Park CB, Kim BW, Wang HJ, Yoon CH, Lee SJ, Yoon G (2011). "Decreased lactate dehydrogenase B expression enhances claudin 1-mediated hepatoma cell invasiveness via mitochondrial defects". Exp. Cell Res. 317 (8): 1108–18. doi:10.1016/j.yexcr.2011.02.011. PMID 21356207.


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.