Lactate permease family
| Lactate permease | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | LctP | ||||||||
| Pfam | PF02652 | ||||||||
| InterPro | IPR003804 | ||||||||
| TCDB | 2.A.14 | ||||||||
| |||||||||
The lactate permease (LctP) family (TC# 2.A.14) is a family of transport proteins belonging to the ion transporter (IT) superfamily.[1]
Function
Characterized members of this family possess 15-18 transmembrane segments (TMSs) and are roughly 460-565 amino acyl residues in length.
General transport reaction
Transport reactions catalyzed by functionally characterized members of the LctP family include:[2]
D- or L-lactate or glycolate (out) + H+ (out) → D- or L-lactate or glycolate (in) + H+ (in).
References
- ^ Prakash S, Cooper G, Singhi S, Saier MH (December 2003). "The ion transporter superfamily". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1618 (1): 79–92. doi:10.1016/j.bbamem.2003.10.010. PMID 14643936.
- ^ "2.A.14 The Lactate Permease (LctP) Family". Transporter Classification Database. Retrieved 2016-03-02.
Further reading
- Moraes TF, Reithmeier RA (November 2012). "Membrane transport metabolons". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1818 (11): 2687–706. doi:10.1016/j.bbamem.2012.06.007. PMID 22705263.
- Núñez MF, Kwon O, Wilson TH, Aguilar J, Baldoma L, Lin EC (January 2002). "Transport of L-Lactate, D-Lactate, and glycolate by the LldP and GlcA membrane carriers of Escherichia coli". Biochemical and Biophysical Research Communications. 290 (2): 824–9. doi:10.1006/bbrc.2001.6255. PMID 11785976.
- Rabus R, Jack DL, Kelly DJ, Saier MH (December 1999). "TRAP transporters: an ancient family of extracytoplasmic solute-receptor-dependent secondary active transporters". Microbiology. 145 (12): 3431–45. doi:10.1099/00221287-145-12-3431. PMID 10627041.
- Saier MH, Eng BH, Fard S, Garg J, Haggerty DA, Hutchinson WJ, Jack DL, Lai EC, Liu HJ, Nusinew DP, Omar AM, Pao SS, Paulsen IT, Quan JA, Sliwinski M, Tseng TT, Wachi S, Young GB (February 1999). "Phylogenetic characterization of novel transport protein families revealed by genome analyses". Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes. 1422 (1): 1–56. doi:10.1016/s0304-4157(98)00023-9. PMID 10082980.
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Biology
As of 12 March 2016, this article is derived in whole or in part from Transporter Classification Database. The copyright holder has licensed the content in a manner that permits reuse under CC BY-SA 3.0 and GFDL. All relevant terms must be followed. The original text was at "2.A.14 The Lactate Permease (LctP) Family"
