MIR146A

Non-coding RNA in the species Homo sapiens

MIR146A

Identifiers

Aliases

MIR146A, MIRN146, MIRN146A, miR-146a, miRNA146A, microRNA 146a

External IDs

OMIM: 610566; GeneCards: MIR146A; OMA:MIR146A - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q33.3	Start	160,485,352 bp^[1]
Band	5q33.3	End	160,485,450 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

kidney

epithelium

glomerulus

prostate

gastrocnemius muscle

tibial arteries

left lobe of thyroid gland

blood

skin of abdomen

spleen

n/a

More reference expression data

BioGPS

n/a

Orthologs

Species

Human

Mouse

Entrez


406938


n/a

Ensembl


ENSG00000283733


n/a

UniProt


n a


n/a

RefSeq (mRNA)


n/a


n/a

RefSeq (protein)


n/a


n/a

Location (UCSC)

Chr 5: 160.49 – 160.49 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

MicroRNA 146a is a small non-coding RNA that in humans is encoded by the MIR146A gene.^[3]

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.^[3]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000283733 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: MicroRNA 146a". Retrieved 2012-01-27.

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Cai X, Lu S, Zhang Z, Gonzalez CM, Damania B, Cullen BR (April 2005). "Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells". Proceedings of the National Academy of Sciences of the United States of America. 102 (15): 5570–5. Bibcode:2005PNAS..102.5570C. doi:10.1073/pnas.0408192102. PMC 556237. PMID 15800047.
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Cameron JE, Yin Q, Fewell C, Lacey M, McBride J, Wang X, Lin Z, Schaefer BC, Flemington EK (February 2008). "Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways". Journal of Virology. 82 (4): 1946–58. doi:10.1128/JVI.02136-07. PMC 2258704. PMID 18057241.
Stanczyk J, Pedrioli DM, Brentano F, Sanchez-Pernaute O, Kolling C, Gay RE, Detmar M, Gay S, Kyburz D (April 2008). "Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis". Arthritis and Rheumatism. 58 (4): 1001–9. doi:10.1002/art.23386. PMID 18383392.
Perry MM, Moschos SA, Williams AE, Shepherd NJ, Larner-Svensson HM, Lindsay MA (April 2008). "Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells". Journal of Immunology. 180 (8): 5689–98. doi:10.4049/jimmunol.180.8.5689. PMC 2639646. PMID 18390754.
Jazdzewski K, Murray EL, Franssila K, Jarzab B, Schoenberg DR, de la Chapelle A (May 2008). "Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 105 (20): 7269–74. Bibcode:2008PNAS..105.7269J. doi:10.1073/pnas.0802682105. PMC 2438239. PMID 18474871.
Labbaye C, Spinello I, Quaranta MT, Pelosi E, Pasquini L, Petrucci E, Biffoni M, Nuzzolo ER, Billi M, Foà R, Brunetti E, Grignani F, Testa U, Peschle C (July 2008). "A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis". Nature Cell Biology. 10 (7): 788–801. doi:10.1038/ncb1741. PMID 18568019. S2CID 30191805.