MIR223

Non-coding RNA in the species Homo sapiens

MIR223

Identifiers

Aliases

MIR223, MIRN223, miRNA223, mir-223, microRNA 223

External IDs

OMIM: 300694; GeneCards: MIR223; OMA:MIR223 - orthologs

Gene location (Human)

Chr.	X chromosome (human)^[1]

Band	Xq12	Start	66,018,870 bp^[1]
Band	Xq12	End	66,018,979 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

blood

left ventricle

sural nerve

gastrocnemius muscle

ascending aorta

adrenal gland

human kidney

tibial arteries

right frontal lobe

right auricle

n/a

More reference expression data

BioGPS

n/a

Orthologs

Species

Human

Mouse

Entrez


407008


n/a

Ensembl


ENSG00000284567


n/a

UniProt


n a


n/a

RefSeq (mRNA)


n/a


n/a

RefSeq (protein)


n/a


n/a

Location (UCSC)

Chr X: 66.02 – 66.02 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

MicroRNA 223 is a protein that in humans is encoded by the MIR223 gene. ^[3]

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding.

The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products.

The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000284567 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MicroRNA 223". Retrieved 2018-08-29.

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Felli N, Pedini F, Romania P, Biffoni M, Morsilli O, Castelli G, Santoro S, Chicarella S, Sorrentino A, Peschle C, Marziali G (April 2009). "MicroRNA 223-dependent expression of LMO2 regulates normal erythropoiesis". Haematologica. 94 (4): 479–86. doi:10.3324/haematol.2008.002345. PMC 2663611. PMID 19278969.