MPHOSPH8

Protein-coding gene in the species Homo sapiens
MPHOSPH8
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3LWE, 3QO2, 3R93, 3SVM

Identifiers
AliasesMPHOSPH8, HSMPP8, TWA3, mpp8, M-phase phosphoprotein 8
External IDsOMIM: 611626; MGI: 1922589; HomoloGene: 11380; GeneCards: MPHOSPH8; OMA:MPHOSPH8 - orthologs
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for MPHOSPH8
Genomic location for MPHOSPH8
Band13q12.11Start19,633,659 bp[1]
End19,673,441 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for MPHOSPH8
Genomic location for MPHOSPH8
Band14|14 C3Start56,905,705 bp[2]
End56,934,887 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tendon of biceps brachii

  • Achilles tendon

  • sural nerve

  • left ovary

  • right ovary

  • canal of the cervix

  • cerebellar hemisphere

  • gastric mucosa

  • body of uterus

  • right hemisphere of cerebellum
Top expressed in
  • zygote

  • primary oocyte

  • secondary oocyte

  • facial motor nucleus

  • primitive streak

  • spermatocyte

  • substantia nigra

  • condyle

  • tail of embryo

  • fossa
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • methylated histone binding
  • protein binding
  • ubiquitin protein ligase binding
  • ubiquitin-protein transferase activity
  • chromatin binding
Cellular component
  • cytoplasm
  • plasma membrane
  • nucleolus
  • nucleus
  • chromosome
  • ubiquitin ligase complex
  • cytosol
  • heterochromatin
Biological process
  • regulation of DNA methylation
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • protein ubiquitination
  • negative regulation of gene expression, epigenetic
  • positive regulation of DNA methylation-dependent heterochromatin assembly
  • negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54737

75339

Ensembl

ENSG00000196199

ENSMUSG00000079184

UniProt

Q99549

Q3TYA6

RefSeq (mRNA)

NM_017520

NM_023773
NM_001360072

RefSeq (protein)

NP_059990

NP_076262
NP_001347001

Location (UCSC)Chr 13: 19.63 – 19.67 MbChr 14: 56.91 – 56.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

M-phase phosphoprotein 8 is an enzyme that in humans is encoded by the MPHOSPH8 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196199 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079184 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (Jan 1997). "Identification of novel M phase phosphoproteins by expression cloning". Mol Biol Cell. 7 (9): 1455–69. doi:10.1091/mbc.7.9.1455. PMC 275994. PMID 8885239.
  6. ^ "Entrez Gene: HSMPP8 M-phase phosphoprotein, mpp8".

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Maksimov VV, Arman IP, Tarantul VZ (2006). "[Identification of the proteins interacting with neuroprotective peptide humanin in a yeast two-hybrid system]". Genetika. 42 (2): 274–7. PMID 16583711.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Umeda M, Nishitani H, Nishimoto T (2003). "A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM". Gene. 303: 47–54. doi:10.1016/S0378-1119(02)01153-8. PMID 12559565.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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