Melanotransferrin

Protein-coding gene in the species Homo sapiens
MELTF
Identifiers
AliasesMELTF, CD228, MAP97, MTF1, MTf, MFI2, melanotransferrin
External IDsOMIM: 155750; MGI: 1353421; HomoloGene: 4335; GeneCards: MELTF; OMA:MELTF - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for MELTF
Genomic location for MELTF
Band3q29Start196,980,590 bp[1]
End197,029,835 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for MELTF
Genomic location for MELTF
Band16|16 B2Start31,697,628 bp[2]
End31,717,838 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibia

  • parotid gland

  • decidua

  • tendon of biceps brachii

  • renal medulla

  • parietal pleura

  • cartilage tissue

  • endothelial cell

  • amniotic fluid

  • germinal epithelium
Top expressed in
  • vestibular sensory epithelium

  • stria vascularis

  • epithelium of small intestine

  • trachea

  • migratory enteric neural crest cell

  • utricle

  • vestibular membrane of cochlear duct

  • intercostal muscle

  • ankle joint

  • condyle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • iron ion binding
  • protein binding
  • metal ion binding
Cellular component
  • cell surface
  • anchored component of plasma membrane
  • anchored component of membrane
  • integral component of plasma membrane
  • extracellular exosome
  • membrane
  • extracellular region
  • extracellular space
  • plasma membrane
  • endoplasmic reticulum lumen
Biological process
  • positive regulation of extracellular matrix disassembly
  • iron ion homeostasis
  • negative regulation of substrate adhesion-dependent cell spreading
  • regulation of cell population proliferation
  • positive regulation of plasminogen activation
  • ion transport
  • regulation of cell growth
  • C-terminal protein lipidation
  • post-translational protein modification
  • transport
  • iron ion transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4241

30060

Ensembl

ENSG00000163975

ENSMUSG00000022780

UniProt

P08582

Q9R0R1

RefSeq (mRNA)

NM_005929
NM_033316

NM_013900

RefSeq (protein)

NP_005920
NP_201573

NP_038928

Location (UCSC)Chr 3: 196.98 – 197.03 MbChr 16: 31.7 – 31.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Melanotransferrin is a protein that in humans is encoded by the MFI2 gene. MFI2 has also recently been designated CD228 (cluster of differentiation 228).

The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants.[5] It is part of neural crest tissue, often present in melanotic neuroectodermal tumor of infancy.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163975 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022780 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5".

Further reading

  • Suryo Rahmanto Y, Dunn LL, Richardson DR (2007). "The melanoma tumor antigen, melanotransferrin (p97): a 25-year hallmark--from iron metabolism to tumorigenesis". Oncogene. 26 (42): 6113–24. doi:10.1038/sj.onc.1210442. PMID 17452986. S2CID 35884470.
  • Baker EN, Baker HM, Smith CA, et al. (1992). "Human melanotransferrin (p97) has only one functional iron-binding site". FEBS Lett. 298 (2–3): 215–8. Bibcode:1992FEBSL.298..215B. doi:10.1016/0014-5793(92)80060-T. PMID 1544447. S2CID 21022972.
  • Garratt RC, Jhotí H (1992). "A molecular model for the tumour-associated antigen, p97, suggests a Zn-binding function". FEBS Lett. 305 (1): 55–61. Bibcode:1992FEBSL.305...55G. doi:10.1016/0014-5793(92)80654-Y. PMID 1633859. S2CID 23569786.
  • Rose TM, Plowman GD, Teplow DB, et al. (1986). "Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence" (PDF). Proc. Natl. Acad. Sci. U.S.A. 83 (5): 1261–5. Bibcode:1986PNAS...83.1261R. doi:10.1073/pnas.83.5.1261. PMC 323055. PMID 2419904.
  • Furukawa KS, Furukawa K, Real FX, et al. (1989). "A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97". J. Exp. Med. 169 (2): 585–90. doi:10.1084/jem.169.2.585. PMC 2189208. PMID 2463331.
  • Sciot R, de Vos R, van Eyken P, et al. (1989). "In situ localization of melanotransferrin (melanoma-associated antigen P97) in human liver. A light- and electronmicroscopic immunohistochemical study". Liver. 9 (2): 110–9. doi:10.1111/j.1600-0676.1989.tb00387.x. PMID 2540389.
  • Seligman PA, Butler CD, Massey EJ, et al. (1986). "The p97 antigen is mapped to the q24-qter region of chromosome 3; the same region as the transferrin receptor". Am. J. Hum. Genet. 38 (4): 540–8. PMC 1684788. PMID 3010712.
  • Le Beau MM, Diaz MO, Plowman GD, et al. (1986). "Chromosomal sublocalization of the human p97 melanoma antigen". Hum. Genet. 72 (4): 294–6. doi:10.1007/BF00290951. PMID 3754536. S2CID 38961040.
  • Plowman GD, Brown JP, Enns CA, et al. (1983). "Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3". Nature. 303 (5912): 70–2. Bibcode:1983Natur.303...70P. doi:10.1038/303070a0. PMID 6843660. S2CID 4332107.
  • Kennard ML, Richardson DR, Gabathuler R, et al. (1995). "A novel iron uptake mechanism mediated by GPI-anchored human p97". EMBO J. 14 (17): 4178–86. doi:10.1002/j.1460-2075.1995.tb00091.x. PMC 394500. PMID 7556058.
  • Food MR, Rothenberger S, Gabathuler R, et al. (1994). "Transport and expression in human melanomas of a transferrin-like glycosylphosphatidylinositol-anchored protein". J. Biol. Chem. 269 (4): 3034–40. doi:10.1016/S0021-9258(17)42043-6. PMID 8300636.
  • Rothenberger S, Food MR, Gabathuler R, et al. (1996). "Coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary endothelium". Brain Res. 712 (1): 117–21. doi:10.1016/0006-8993(96)88505-2. PMID 8705293. S2CID 45470799.
  • Chi DD, Merchant RE, Rand R, et al. (1997). "Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas". Am. J. Pathol. 150 (6): 2143–52. PMC 1858329. PMID 9176405.
  • Richardson DR (2000). "The role of the membrane-bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell". Eur. J. Biochem. 267 (5): 1290–8. doi:10.1046/j.1432-1327.2000.01079.x. PMID 10691965.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC 311086. PMID 11337467.
  • Sekyere E, Food MR, Richardson DR (2002). "A second melanotransferrin gene (MTf2) and a novel protein isoform: explanation for the membrane-bound and soluble forms of melanotransferrin?". FEBS Lett. 512 (1–3): 350–2. Bibcode:2002FEBSL.512..350S. doi:10.1016/S0014-5793(02)02248-2. PMID 11852110. S2CID 38104056.
  • Food MR, Sekyere EO, Richardson DR (2002). "The soluble form of the membrane-bound transferrin homologue, melanotransferrin, inefficiently donates iron to cells via nonspecific internalization and degradation of the protein". Eur. J. Biochem. 269 (18): 4435–45. doi:10.1046/j.1432-1033.2002.03140.x. PMID 12230555.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Guo J, Wen DR, Huang RR, et al. (2003). "Detection of multiple melanoma-associated markers in melanoma cell lines by RT in situ PCR". Exp. Mol. Pathol. 74 (2): 140–7. doi:10.1016/S0014-4800(03)00012-1. PMID 12710945.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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