Monosodium citrate
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Names | |
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IUPAC name Sodium 2-(carboxymethyl)-2,4-dihydroxy-4-oxobutanoate[1] | |
Other names sodium dihydrogen 2-hydroxypropane-1,2,3-tricarboxylate | |
Identifiers | |
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ECHA InfoCard | 100.038.834 ![]() |
EC Number |
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E number | E331i (antioxidants, ...) |
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InChI
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Properties | |
Chemical formula | C6H7NaO7 |
Molar mass | 214.105 g·mol−1 |
Appearance | white powder hygroscopic |
Odor | odorless |
Melting point | 212 °C (414 °F; 485 K) |
Boiling point | 309.6 °C (589.3 °F; 582.8 K) |
Solubility in water | soluble |
Solubility | negligible in ethanol |
Acidity (pKa) | 3.50–3.80 |
Structure[2] | |
Monoclinic | |
P21/a (No. 4) | |
Formula units (Z) | 4 |
Hazards | |
Lethal dose or concentration (LD, LC): | |
LD50 (median dose) | 5400 mg/kg (mouse, oral) >2000 mg/kg (rat, dermal) |
Safety data sheet (SDS) | Carl Roth |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ![]() ![]() ![]() Infobox references |
Chemical compound
Monosodium citrate, more correctly, sodium dihydrogen citrate (Latin: natrium citricum acidulatum), is an acid salt of citric acid. Disodium citrate and trisodium citrate are also known. It can be prepared by partial neutralisation of citric acid[3] with an aqueous solution of sodium bicarbonate or carbonate. It has a slightly acidic taste.[3]
- NaHCO3 + C6H8O7 → NaC6H7O7 + CO2 + H2O
- Na2CO3 + 2C6H8O7 → 2NaC6H7O7 + CO2 + H2O
It is highly soluble in water and practically insoluble in ethanol.[3] Monosodium citrate is used as an anticoagulant in donated blood.[4] It is used as an alkalinizing agent to prevent kidney stone disease.[5] The crystals form as nearly perfect cubes.[6]
References
- ^ https://pubchem.ncbi.nlm.nih.gov/compound/23662352#section=IUPAC-Name&fullscreen=true [bare URL]
- ^ Glusker, Jenny P.; van der Helm, D.; Love, Warner E.; Dornberg, Marilyn L.; Patterson, A. L. (June 1960). "The State of Ionization of Crystalline Sodium Dihydrogen Citrate1". Journal of the American Chemical Society. 82 (11): 2964–2965. doi:10.1021/ja01496a071. ISSN 0002-7863. Retrieved 22 July 2022.
- ^ a b c "Monosodium Citrate - Jungbunzlauer". www.jungbunzlauer.com. Retrieved 17 July 2022.
- ^ Clinical Hematology: Theory and Procedures, Mary Louise Turgeon
- ^ PubChem. "Monosodium citrate". pubchem.ncbi.nlm.nih.gov. Retrieved 2021-08-02.
- ^ Hitchcock, David I. (March 1946). "Sodium Hydrogen Citrates". Journal of the American Chemical Society. 68 (3): 524–525. doi:10.1021/ja01207a507. ISSN 0002-7863. PMID 21015754. Retrieved 22 July 2022.
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